| Literature DB >> 33474631 |
Jasna Metovic1, Giuseppe Pelosi2,3, Marco Barella4, Fabrizio Bianchi5, Paul Hofman6, Veronique Hofman6, Myriam Remmelink7, Izidor Kern8, Lina Carvalho9, Linda Pattini10, Angelica Sonzogni11, Giulia Veronesi12,13, Sergio Harari14,15, Fabien Forest16, Mauro Papotti1.
Abstract
Neuroendocrine neoplasms (NENs) of the lung encompass neuroendocrine tumors (NETs) composed of typical (TC) and atypical (AC) carcinoids and full-fledged carcinomas (NECs) inclusive of large cell neuroendocrine carcinoma (LCNEC) and small cell carcinoma (SCLC). NETs and NECs are thought to represent distinct and separate lesions with neither molecular overlap nor common developmental continuum. Two perspectives were addressed regarding the morphologic and molecular classification of lung NENs: (i) a supervised approach by browsing the traditional classification, the relevant gene alterations, and their clinical implications; and (ii) an unsupervised approach, by reappraising neoplasms according to risk factors and natural history of disease to construct an interpretation model relied on biological data. We herein emphasize lights and shadows of the current classification of lung NENs and provide an alternative outlook on these tumors focused on what we currently know about the biological determinants and the natural history of disease.Entities:
Keywords: Atypical; Carcinoid; Carcinoma; Classification; Differentiation; Gene; Large cell; Lung; Molecular; Neuroendocrine; Progression; Signature; Small cell; Stem cell; Typical
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Year: 2021 PMID： 33474631 PMCID： PMC7966641 DOI： 10.1007/s00428-020-03015-z
Source DB: PubMed Journal: Virchows Arch ISSN： 0945-6317 Impact factor: 4.064