Su Pei Khoo1, Mohd Khairul Anwar Shafii1, Nirmala Bhoo-Pathy1, Siew Hwei Yap1, Shridevi Subramaniam2, Nazrila Hairizan Nasir3, Zhang Lin4, Jerome Belinson5, Pik Pin Goh2, Xinfeng Qu5, Patti Gravitt6, Yin Ling Woo1. 1. Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia. 2. National Clinical Research Centre, Ministry of Health, Putrajaya, Malaysia. 3. Division of Family Health Development, Ministry of Health, Putrajaya, Malaysia. 4. Beijing Genome Institute, Shen Zhen, China. 5. Preventive Oncology International Inc and the Cleveland Clinic, Cleveland, Ohio, United States of America. 6. Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, Maryland, United States of America.
Abstract
BACKGROUND: Addressing the burden of HPV-associated diseases among men is increasingly becoming a public health issue. The main objective of this study was to determine HPV prevalence among a healthy community-based Malaysian men. METHOD: This was a cross-sectional study that recruited 503 healthy males from 3 community-based clinics in Selangor, Malaysia. Genital and anal samples were collected from each participant for 14 high risk and 2 low risk HPV DNA detection and genotyping. All participants responded to a set of detailed sociodemographic and sexual behaviour questionnaire. RESULTS: The median age at enrolment was 40 years old (IQR: 31-50). The anogenital HPV6/11 prevalence was 3.2% whereas high risk HPV prevalence was 27.1%. The genital HPV prevalence for HPV6/11 was 2.9% while high risk HPV was 18.8%. HPV6/11 prevalence in the anal canal was 1.6% and high risk HPV was 12.7%. HPV 18 was the most prevalent genotype detected in the anogenital area. There was a significant independent association between genital and anal HPV infections. CONCLUSION: Anogenital HPV infection is common among Malaysian men. These findings emphasize the ubiquity of HPV infection and thus the value of population-wide access to HPV prevention.
BACKGROUND: Addressing the burden of HPV-associated diseases among men is increasingly becoming a public health issue. The main objective of this study was to determine HPV prevalence among a healthy community-based Malaysian men. METHOD: This was a cross-sectional study that recruited 503 healthy males from 3 community-based clinics in Selangor, Malaysia. Genital and anal samples were collected from each participant for 14 high risk and 2 low risk HPV DNA detection and genotyping. All participants responded to a set of detailed sociodemographic and sexual behaviour questionnaire. RESULTS: The median age at enrolment was 40 years old (IQR: 31-50). The anogenital HPV6/11 prevalence was 3.2% whereas high risk HPV prevalence was 27.1%. The genital HPV prevalence for HPV6/11 was 2.9% while high risk HPV was 18.8%. HPV6/11 prevalence in the anal canal was 1.6% and high risk HPV was 12.7%. HPV 18 was the most prevalent genotype detected in the anogenital area. There was a significant independent association between genital and anal HPV infections. CONCLUSION:Anogenital HPV infection is common among Malaysian men. These findings emphasize the ubiquity of HPV infection and thus the value of population-wide access to HPV prevention.
Authors: Daniel C Beachler; Aimée R Kreimer; Mark Schiffman; Rolando Herrero; Sholom Wacholder; Ana Cecilia Rodriguez; Douglas R Lowy; Carolina Porras; John T Schiller; Wim Quint; Silvia Jimenez; Mahboobeh Safaeian; Linda Struijk; John Schussler; Allan Hildesheim; Paula Gonzalez Journal: J Natl Cancer Inst Date: 2015-10-14 Impact factor: 13.506
Authors: Eileen F Dunne; Carrie M Nielson; Katherine M Stone; Lauri E Markowitz; Anna R Giuliano Journal: J Infect Dis Date: 2006-09-12 Impact factor: 5.226
Authors: Stephen Goldstone; Joel M Palefsky; Anna R Giuliano; Edson D Moreira; Carlos Aranda; Heiko Jessen; Richard J Hillman; Daron G Ferris; Francois Coutlee; Kai-Li Liaw; J Brooke Marshall; Xuehong Zhang; Scott Vuocolo; Eliav Barr; Richard M Haupt; Dalya Guris; Elizabeth I O Garner Journal: J Infect Dis Date: 2011-01-01 Impact factor: 5.226
Authors: Isabel C Scarinci; Francisco A R Garcia; Erin Kobetz; Edward E Partridge; Heather M Brandt; Maria C Bell; Mark Dignan; Grace X Ma; Jane L Daye; Philip E Castle Journal: Cancer Date: 2010-06-01 Impact factor: 6.860
Authors: Ahmedin Jemal; Edgar P Simard; Christina Dorell; Anne-Michelle Noone; Lauri E Markowitz; Betsy Kohler; Christie Eheman; Mona Saraiya; Priti Bandi; Debbie Saslow; Kathleen A Cronin; Meg Watson; Mark Schiffman; S Jane Henley; Maria J Schymura; Robert N Anderson; David Yankey; Brenda K Edwards Journal: J Natl Cancer Inst Date: 2013-01-07 Impact factor: 13.506
Authors: H N Xin; H J Li; Z Li; X W Li; M F Li; H R Zhang; B X Feng; W H Lun; H W Yan; J Long; L Gao Journal: Epidemiol Infect Date: 2017-08-08 Impact factor: 4.434
Authors: Lyriane Apolinário de Araújo; Adriano Augusto Peclat De Paula; Hellen da Silva Cintra de Paula; Jessica Enocêncio Porto Ramos; Brunna Rodrigues de Oliveira; Keila Patrícia Almeida De Carvalho; Rafael Alves Guimarães; Rita de Cássia Gonçalves de Alencar; Eliza Carla Barroso Duarte; Silvia Helena Rabelo Santos; Vera Aparecida Saddi; Megmar Aparecida Dos Santos Carneiro Journal: PLoS One Date: 2018-06-27 Impact factor: 3.240
Authors: Paul K S Chan; Wendy C S Ho; Martin C W Chan; Martin C S Wong; Apple C M Yeung; Josette S Y Chor; Mamie Hui Journal: PLoS One Date: 2014-09-17 Impact factor: 3.240