BACKGROUND: We examined the baseline prevalence of penile, scrotal, perineal/perianal, and intra-anal human papillomavirus (HPV) infection in human immunodeficiency virus (HIV)-seronegative men who have sex with men (MSM). METHODS: Data were analyzed from 602 MSM aged 16-27 years with ≤ 5 lifetime sexual partners. Serum samples were tested for antibodies to HPV6/11/16/18. Swab samples were collected separately from several anogenital areas for detection of HPV6/11/16/18/31/33/35/39/45/51/52/56/58/59 DNA. RESULTS: The prevalence of any tested HPV type was 18.5% at the penis, 17.1% at the scrotum, 33.0% at the perineal/perianal region, 42.4% in the anal canal, and 48.0% at any site. Overall, 415 MSM (69.7%) were negative to HPV 6, 11, 16, and 18 at enrollment by both serology and DNA detection. Men residing in Europe and Latin America had significantly increased risk of HPV infection at external genital sites and the anal canal compared to men from Australia. Tobacco use and greater number of lifetime sexual partners was associated with higher HPV infection prevalence. CONCLUSIONS: The prevalence of HPV infection is high among young sexually active MSM, with the anal canal being the most common site of infection. Lifetime number of sexual partners was the most important modifiable risk factor for anogenital HPV infection.
BACKGROUND: We examined the baseline prevalence of penile, scrotal, perineal/perianal, and intra-anal human papillomavirus (HPV) infection in human immunodeficiency virus (HIV)-seronegative men who have sex with men (MSM). METHODS: Data were analyzed from 602 MSM aged 16-27 years with ≤ 5 lifetime sexual partners. Serum samples were tested for antibodies to HPV6/11/16/18. Swab samples were collected separately from several anogenital areas for detection of HPV6/11/16/18/31/33/35/39/45/51/52/56/58/59 DNA. RESULTS: The prevalence of any tested HPV type was 18.5% at the penis, 17.1% at the scrotum, 33.0% at the perineal/perianal region, 42.4% in the anal canal, and 48.0% at any site. Overall, 415 MSM (69.7%) were negative to HPV 6, 11, 16, and 18 at enrollment by both serology and DNA detection. Men residing in Europe and Latin America had significantly increased risk of HPV infection at external genital sites and the anal canal compared to men from Australia. Tobacco use and greater number of lifetime sexual partners was associated with higher HPV infection prevalence. CONCLUSIONS: The prevalence of HPV infection is high among young sexually active MSM, with the anal canal being the most common site of infection. Lifetime number of sexual partners was the most important modifiable risk factor for anogenital HPV infection.
Authors: Eftyhia Vardas; Anna R Giuliano; Stephen Goldstone; Joel M Palefsky; Edson D Moreira; Mary E Penny; Carlos Aranda; Heiko Jessen; Harald Moi; Daron G Ferris; Kai-Li Liaw; J Brooke Marshall; Scott Vuocolo; Eliav Barr; Richard M Haupt; Elizabeth I O Garner; Dalya Guris Journal: J Infect Dis Date: 2011-01-01 Impact factor: 5.226
Authors: Peter V Chin-Hong; Eric Vittinghoff; Ross D Cranston; Susan Buchbinder; Daniel Cohen; Grant Colfax; Maria Da Costa; Teresa Darragh; Eileen Hess; Franklyn Judson; Beryl Koblin; Maria Madison; Joel M Palefsky Journal: J Infect Dis Date: 2004-11-10 Impact factor: 5.226
Authors: Eric M van der Snoek; Hubert G M Niesters; Paul G H Mulder; Gerard J J van Doornum; Albert D M E Osterhaus; Willem I van der Meijden Journal: Sex Transm Dis Date: 2003-08 Impact factor: 2.830
Authors: Beibei Lu; Yougui Wu; Carrie M Nielson; Roberto Flores; Martha Abrahamsen; Mary Papenfuss; Robin B Harris; Anna R Giuliano Journal: J Infect Dis Date: 2009-02-01 Impact factor: 5.226
Authors: David Opalka; Charles E Lachman; Stefani A MacMullen; Kathrin U Jansen; Judith F Smith; Narendra Chirmule; Mark T Esser Journal: Clin Diagn Lab Immunol Date: 2003-01
Authors: Alan G Nyitray; Roberto J Carvalho da Silva; Maria Luiza Baggio; Beibei Lu; Dan'elle Smith; Martha Abrahamsen; Mary Papenfuss; Manuel Quiterio; Luisa L Villa; Anna R Giuliano Journal: Sex Transm Dis Date: 2011-10 Impact factor: 2.830
Authors: Emmanuel Chandler; Lili Ding; Pamina Gorbach; Eduardo L Franco; Darron A Brown; Lea E Widdice; David I Bernstein; Jessica A Kahn Journal: J Adolesc Health Date: 2018-07 Impact factor: 5.012
Authors: Erin M Kahle; Elissa Meites; R Craig Sineath; Muazzam Nasrullah; Kristina E Bowles; Elizabeth DiNenno; Patrick S Sullivan; Travis Sanchez Journal: Sex Transm Dis Date: 2017-01 Impact factor: 2.830
Authors: Carmen Hidalgo-Tenorio; Jessica Ramírez-Taboada; Concepción Gil-Anguita; Javier Esquivias; Mohamed Omar-Mohamed-Balgahata; Antonio SamPedro; Miguel Lopez-Ruz; Juan Pasquau Journal: AIDS Res Ther Date: 2017-07-18 Impact factor: 2.250
Authors: Rachna Sharma; Jimmy T Efird; Aung Chein; Elizabeth A Holly; Mel Krajden; J Michael Berry; Teresa M Darragh; Naomi Jay; Joel M Palefsky Journal: J Acquir Immune Defic Syndr Date: 2013-12-15 Impact factor: 3.731
Authors: Madina Agénor; Sarah M Peitzmeier; Allegra R Gordon; Brittany M Charlton; Sebastien Haneuse; Jennifer Potter; S Bryn Austin Journal: Cancer Causes Control Date: 2016-08-09 Impact factor: 2.506