| Literature DB >> 33470210 |
Carri K Glide-Hurst1, Percy Lee2, Adam D Yock3, Jeffrey R Olsen4, Minsong Cao5, Farzan Siddiqui6, William Parker7, Anthony Doemer6, Yi Rong8, Amar U Kishan5, Stanley H Benedict8, X Allen Li9, Beth A Erickson9, Jason W Sohn10, Ying Xiao11, Evan Wuthrick12.
Abstract
The integration of adaptive radiation therapy (ART), or modifying the treatment plan during the treatment course, is becoming more widely available in clinical practice. ART offers strong potential for minimizing treatment-related toxicity while escalating or de-escalating target doses based on the dose to organs at risk. Yet, ART workflows add complexity into the radiation therapy planning and delivery process that may introduce additional uncertainties. This work sought to review presently available ART workflows and technological considerations such as image quality, deformable image registration, and dose accumulation. Quality assurance considerations for ART components and minimum recommendations are described. Personnel and workflow efficiency recommendations are provided, as is a summary of currently available clinical evidence supporting the implementation of ART. Finally, to guide future clinical trial protocols, an example ART physician directive and a physics template following standard NRG Oncology protocol is provided.Entities:
Mesh：
Year: 2020 PMID： 33470210 PMCID： PMC8290862 DOI： 10.1016/j.ijrobp.2020.10.021
Source DB: PubMed Journal: Int J Radiat Oncol Biol Phys ISSN： 0360-3016 Impact factor: 7.038