Literature DB >> 33468564

British Gynaecological Cancer Society/British Association of Gynaecological Pathology consensus for germline and tumor testing for BRCA1/2 variants in ovarian cancer in the United Kingdom.

Sudha Sundar1,2, Ranjit Manchanda3, Charlie Gourley4, Angela George5, Andrew Wallace6, Janos Balega7, Sarah Williams8, Yvonne Wallis9, Richard Edmondson10, Shibani Nicum11, Jonathan Frost12, Ayoma Attygalle13, Christina Fotopoulou14, Rebecca Bowen12, Dani Bell15, Ketankumar Gajjar16, Bruce Ramsay17, Nicholas J Wood18, Sadaf Ghaem-Maghami19, Tracie Miles20, Raji Ganesan21.   

Abstract

The British Gynecological Cancer Society and the British Association of Gynecological Pathologists established a multidisciplinary consensus group comprising experts in surgical gynecological oncology, medical oncology, genetics, and laboratory science, and clinical nurse specialists to identify the optimal pathways to BRCA germline and tumor testing in patients with ovarian cancer in routine clinical practice. In particular, the group explored models of consent, quality standards identified at pathology laboratories, and experience and data from pioneering cancer centers. The group liaised with representatives from ovarian cancer charities to also identify patient perspectives that would be important to implementation. Recommendations from these consensus group deliberations are presented in this manuscript. © IGCS and ESGO 2021. No commercial re-use. See rights and permissions. Published by BMJ.

Entities:  

Keywords:  BRCA1 protein; BRCA2 protein; fallopian tube neoplasms; ovarian neoplasms

Mesh:

Substances:

Year:  2021        PMID: 33468564     DOI: 10.1136/ijgc-2020-002112

Source DB:  PubMed          Journal:  Int J Gynecol Cancer        ISSN: 1048-891X            Impact factor:   3.437


  5 in total

1.  Healthcare professionals' perspectives on implementation of universal tumor DNA testing in ovarian cancer patients: multidisciplinary focus groups.

Authors:  Margreet G E M Ausems; Joanne A de Hullu; Vera M Witjes; Jozé C C Braspenning; Nicoline Hoogerbrugge; Yvonne H C M Smolders; Dorien M A Hermkens; Marian J E Mourits; Marjolijn J L Ligtenberg
Journal:  Fam Cancer       Date:  2022-05-16       Impact factor: 2.375

Review 2.  BRCA1/2 in non-mucinous epithelial ovarian cancer: tumour with or without germline testing?

Authors:  Robert D Morgan; George J Burghel; Nicola Flaum; Michael Bulman; Philip Smith; Andrew R Clamp; Jurjees Hasan; Claire L Mitchell; Zena Salih; Emma R Woodward; Fiona Lalloo; Emma J Crosbie; Richard J Edmondson; Andrew J Wallace; Gordon C Jayson; D Gareth R Evans
Journal:  Br J Cancer       Date:  2022-03-08       Impact factor: 9.075

3.  The detection of germline and somatic BRCA1/2 genetic variants through parallel testing of patients with high-grade serous ovarian cancer: a national retrospective audit.

Authors:  B Frugtniet; S Morgan; A Murray; S Palmer-Smith; R White; R Jones; L Hanna; C Fuller; E Hudson; A Mullard; A E Quinton
Journal:  BJOG       Date:  2021-11-08       Impact factor: 7.331

4.  Tumour Versus Germline BRCA Testing in Ovarian Cancer: A Single-Site Institution Experience in the United Kingdom.

Authors:  Iolia Akaev; Siavash Rahimi; Olubukola Onifade; Francis John Edward Gardner; David Castells-Rufas; Eleanor Jones; Shyamika Acharige; Chit Cheng Yeoh
Journal:  Diagnostics (Basel)       Date:  2021-03-19

5.  Real-World Data on Detection of Germline and Somatic Pathogenic/Likely Pathogenic Variants in BRCA1/2 and Other Susceptibility Genes in Ovarian Cancer Patients Using Next Generation Sequencing.

Authors:  Vida Stegel; Ana Blatnik; Erik Škof; Vita Šetrajčič Dragoš; Mateja Krajc; Brigita Gregorič; Petra Škerl; Ksenija Strojnik; Gašper Klančar; Marta Banjac; Janez Žgajnar; Maja Ravnik; Srdjan Novaković
Journal:  Cancers (Basel)       Date:  2022-03-10       Impact factor: 6.639

  5 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.