Literature DB >> 33467983

Genetic variants in human BCL2L11 (BIM) are associated with ulcerative forms of Buruli ulcer.

João Fevereiro1,2, Alexandra G Fraga1,2, Carlos Capela1,2, Ghislain E Sopoh3,4, Ange Dossou3, Gilbert Adjimon Ayelo3, Maria João Peixoto1,2, Cristina Cunha1,2, Agostinho Carvalho1,2, Fernando Rodrigues1,2, Jorge Pedrosa1,2.   

Abstract

Buruli ulcer (BU) is a devastating skin mycobacterial infection characterized by extensive cell death, which was previously suggested to be mediated by Bcl2-like protein 11 (BIM, encoded by the BCL2L11 gene). We here report the association of genetic variants in BCL2L11 with ulcerative forms of the disease in a cohort of 618 Beninese individuals. Our results show that regulation of apoptosis in humans contributes to BU lesions associated with worse prognosis, prompting for further investigation on the implementation of novel methods for earlier identification of at-risk patients.

Entities:  

Keywords:  Mycobacterium ulcerans ; BIM; Candidate gene; Single Nucleotide Polymorphism; rs13421194

Mesh：

Substances：

Year:  2021        PMID： 33467983      PMCID： PMC7889264          DOI： 10.1080/22221751.2021.1878936

Source DB:  PubMed          Journal:  Emerg Microbes Infect        ISSN： 2222-1751            Impact factor:   7.163


  14 in total

1.  Identification of patterns in biological sequences at the ALGGEN server: PROMO and MALGEN.

Authors:  Domènec Farré; Romà Roset; Mario Huerta; José E Adsuara; Llorenç Roselló; M Mar Albà; Xavier Messeguer
Journal:  Nucleic Acids Res       Date:  2003-07-01       Impact factor: 16.971

2.  Haploview: analysis and visualization of LD and haplotype maps.

Authors:  J C Barrett; B Fry; J Maller; M J Daly
Journal:  Bioinformatics       Date:  2004-08-05       Impact factor: 6.937

3.  PLINK: a tool set for whole-genome association and population-based linkage analyses.

Authors:  Shaun Purcell; Benjamin Neale; Kathe Todd-Brown; Lori Thomas; Manuel A R Ferreira; David Bender; Julian Maller; Pamela Sklar; Paul I W de Bakker; Mark J Daly; Pak C Sham
Journal:  Am J Hum Genet       Date:  2007-07-25       Impact factor: 11.025

4.  Integrating common and rare genetic variation in diverse human populations.

Authors:  David M Altshuler; Richard A Gibbs; Leena Peltonen; David M Altshuler; Richard A Gibbs; Leena Peltonen; Emmanouil Dermitzakis; Stephen F Schaffner; Fuli Yu; Leena Peltonen; Emmanouil Dermitzakis; Penelope E Bonnen; David M Altshuler; Richard A Gibbs; Paul I W de Bakker; Panos Deloukas; Stacey B Gabriel; Rhian Gwilliam; Sarah Hunt; Michael Inouye; Xiaoming Jia; Aarno Palotie; Melissa Parkin; Pamela Whittaker; Fuli Yu; Kyle Chang; Alicia Hawes; Lora R Lewis; Yanru Ren; David Wheeler; Richard A Gibbs; Donna Marie Muzny; Chris Barnes; Katayoon Darvishi; Matthew Hurles; Joshua M Korn; Kati Kristiansson; Charles Lee; Steven A McCarrol; James Nemesh; Emmanouil Dermitzakis; Alon Keinan; Stephen B Montgomery; Samuela Pollack; Alkes L Price; Nicole Soranzo; Penelope E Bonnen; Richard A Gibbs; Claudia Gonzaga-Jauregui; Alon Keinan; Alkes L Price; Fuli Yu; Verneri Anttila; Wendy Brodeur; Mark J Daly; Stephen Leslie; Gil McVean; Loukas Moutsianas; Huy Nguyen; Stephen F Schaffner; Qingrun Zhang; Mohammed J R Ghori; Ralph McGinnis; William McLaren; Samuela Pollack; Alkes L Price; Stephen F Schaffner; Fumihiko Takeuchi; Sharon R Grossman; Ilya Shlyakhter; Elizabeth B Hostetter; Pardis C Sabeti; Clement A Adebamowo; Morris W Foster; Deborah R Gordon; Julio Licinio; Maria Cristina Manca; Patricia A Marshall; Ichiro Matsuda; Duncan Ngare; Vivian Ota Wang; Deepa Reddy; Charles N Rotimi; Charmaine D Royal; Richard R Sharp; Changqing Zeng; Lisa D Brooks; Jean E McEwen
Journal:  Nature       Date:  2010-09-02       Impact factor: 49.962

5.  The Macrolide Toxin Mycolactone Promotes Bim-Dependent Apoptosis in Buruli Ulcer through Inhibition of mTOR.

Authors:  Raphael Bieri; Nicole Scherr; Marie-Thérèse Ruf; Jean-Pierre Dangy; Philipp Gersbach; Matthias Gehringer; Karl-Heinz Altmann; Gerd Pluschke
Journal:  ACS Chem Biol       Date:  2017-03-27       Impact factor: 5.100

6.  IL-12+IL-18 Cosignaling in Human Macrophages and Lung Epithelial Cells Activates Cathelicidin and Autophagy, Inhibiting Intracellular Mycobacterial Growth.

Authors:  Rui Yang; Enzhuo Yang; Ling Shen; Robert L Modlin; Hongbo Shen; Zheng W Chen
Journal:  J Immunol       Date:  2018-02-16       Impact factor: 5.422

7.  Ensembl 2020.

Authors:  Andrew D Yates; Premanand Achuthan; Wasiu Akanni; James Allen; Jamie Allen; Jorge Alvarez-Jarreta; M Ridwan Amode; Irina M Armean; Andrey G Azov; Ruth Bennett; Jyothish Bhai; Konstantinos Billis; Sanjay Boddu; José Carlos Marugán; Carla Cummins; Claire Davidson; Kamalkumar Dodiya; Reham Fatima; Astrid Gall; Carlos Garcia Giron; Laurent Gil; Tiago Grego; Leanne Haggerty; Erin Haskell; Thibaut Hourlier; Osagie G Izuogu; Sophie H Janacek; Thomas Juettemann; Mike Kay; Ilias Lavidas; Tuan Le; Diana Lemos; Jose Gonzalez Martinez; Thomas Maurel; Mark McDowall; Aoife McMahon; Shamika Mohanan; Benjamin Moore; Michael Nuhn; Denye N Oheh; Anne Parker; Andrew Parton; Mateus Patricio; Manoj Pandian Sakthivel; Ahamed Imran Abdul Salam; Bianca M Schmitt; Helen Schuilenburg; Dan Sheppard; Mira Sycheva; Marek Szuba; Kieron Taylor; Anja Thormann; Glen Threadgold; Alessandro Vullo; Brandon Walts; Andrea Winterbottom; Amonida Zadissa; Marc Chakiachvili; Bethany Flint; Adam Frankish; Sarah E Hunt; Garth IIsley; Myrto Kostadima; Nick Langridge; Jane E Loveland; Fergal J Martin; Joannella Morales; Jonathan M Mudge; Matthieu Muffato; Emily Perry; Magali Ruffier; Stephen J Trevanion; Fiona Cunningham; Kevin L Howe; Daniel R Zerbino; Paul Flicek
Journal:  Nucleic Acids Res       Date:  2020-01-08       Impact factor: 16.971

8.  Genome-wide association study of Buruli ulcer in rural Benin highlights role of two LncRNAs and the autophagy pathway.

Authors:  Jeremy Manry; Quentin B Vincent; Christian Johnson; Maya Chrabieh; Lazaro Lorenzo; Ioannis Theodorou; Marie-Françoise Ardant; Estelle Marion; Annick Chauty; Laurent Marsollier; Laurent Abel; Alexandre Alcaïs
Journal:  Commun Biol       Date:  2020-04-20

9.  Genetic Variation in Autophagy-Related Genes Influences the Risk and Phenotype of Buruli Ulcer.

Authors:  Carlos Capela; Ange Dodji Dossou; Rita Silva-Gomes; Ghislain Emmanuel Sopoh; Michel Makoutode; João Filipe Menino; Alexandra Gabriel Fraga; Cristina Cunha; Agostinho Carvalho; Fernando Rodrigues; Jorge Pedrosa
Journal:  PLoS Negl Trop Dis       Date:  2016-04-29

10.  The long non-coding RNA Morrbid regulates Bim and short-lived myeloid cell lifespan.

Authors:  Jonathan J Kotzin; Sean P Spencer; Sam J McCright; Dinesh B Uthaya Kumar; Magalie A Collet; Walter K Mowel; Ellen N Elliott; Asli Uyar; Michelle A Makiya; Margaret C Dunagin; Christian C D Harman; Anthony T Virtue; Stella Zhu; Will Bailis; Judith Stein; Cynthia Hughes; Arjun Raj; E John Wherry; Loyal A Goff; Amy D Klion; John L Rinn; Adam Williams; Richard A Flavell; Jorge Henao-Mejia
Journal:  Nature       Date:  2016-08-15       Impact factor: 49.962
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  3 in total

1.  Overview: Mycolactone , the Macrolide Toxin of Mycobacterium ulcerans.

Authors:  Katharina Röltgen; Gerd Pluschke
Journal:  Methods Mol Biol       Date:  2022

2.  Molecular and epidemiological characterization of recurrent Mycobacterium ulcerans infections in Benin.

Authors:  Ronald Gnimavo; Alban Besnard; Horace Degnonvi; Juliana Pipoli Da Fonseca; Marie Kempf; Christian Roch Johnson; Alexandra Boccarossa; Yao Télesphore Brou; Laurent Marsollier; Estelle Marion
Journal:  PLoS Negl Trop Dis       Date:  2021-12-28

Review 3.  Mycobacterial skin infection.

Authors:  Giulia Gardini; Natalia Gregori; Alberto Matteelli; Francesco Castelli
Journal:  Curr Opin Infect Dis       Date:  2022-04-01       Impact factor: 4.915
  3 in total

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