OBJECTIVE: Obesity has been shown to be associated with adverse outcomes in viral infections such as influenza, but previous studies on coronavirus disease 2019 (COVID-19) had mixed results. The aim of this systematic review is to investigate the relationship between COVID-19 and obesity. METHODS: We performed a systematic review and meta-analysis. A literature search of MEDLINE, EMBASE, Scopus, Web of Science, CENTRAL, OpenGrey and preprint servers medRxiv and bioRxiv was performed, with no restriction on language or date of publication. Primary outcomes of this study were intensive care unit (ICU) admission or critical disease, severe disease and mortality. Secondary outcome was a positive COVID-19 test. Meta-analysis was performed using OpenMeta-Analyst software, and heterogeneity was tested using Cochran's Q test and I2 statistic. The study protocol was registered on PROSPERO (CRD42020184953). RESULTS: A total of 1,493 articles were identified and 61 studies on 270,241 patients were included. The pooled prevalence of obesity was 27.6% (95% confidence interval [CI] 22.0-33.2) in hospitalised patients. Obesity was not significantly associated with increased ICU admission or critical illness (odds ratio [OR] 1.25, 95% CI 0.99-1.58, P=0.062, I2 =31.0) but was significantly associated with more severe disease (OR 3.13, 95% CI 1.41-6.92, P=0.005, I2 =82.6), mortality (OR 1.36, 95% CI 1.09-1.69, P=0.006, I2=88.5) and a positive COVID-19 test (OR 1.50, 95% CI 1.25-1.81, P<0.001). CONCLUSION: Obesity increased the risk of severe disease, mortality and infection with COVID-19. Higher body mass index was associated with ICU admission and critical disease. Patients who are obese may be more susceptible to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, and infected patients should be monitored closely for adverse outcomes.
OBJECTIVE:Obesity has been shown to be associated with adverse outcomes in viral infections such as influenza, but previous studies on coronavirus disease 2019 (COVID-19) had mixed results. The aim of this systematic review is to investigate the relationship between COVID-19 and obesity. METHODS: We performed a systematic review and meta-analysis. A literature search of MEDLINE, EMBASE, Scopus, Web of Science, CENTRAL, OpenGrey and preprint servers medRxiv and bioRxiv was performed, with no restriction on language or date of publication. Primary outcomes of this study were intensive care unit (ICU) admission or critical disease, severe disease and mortality. Secondary outcome was a positive COVID-19 test. Meta-analysis was performed using OpenMeta-Analyst software, and heterogeneity was tested using Cochran's Q test and I2 statistic. The study protocol was registered on PROSPERO (CRD42020184953). RESULTS: A total of 1,493 articles were identified and 61 studies on 270,241 patients were included. The pooled prevalence of obesity was 27.6% (95% confidence interval [CI] 22.0-33.2) in hospitalised patients. Obesity was not significantly associated with increased ICU admission or critical illness (odds ratio [OR] 1.25, 95% CI 0.99-1.58, P=0.062, I2 =31.0) but was significantly associated with more severe disease (OR 3.13, 95% CI 1.41-6.92, P=0.005, I2 =82.6), mortality (OR 1.36, 95% CI 1.09-1.69, P=0.006, I2=88.5) and a positive COVID-19 test (OR 1.50, 95% CI 1.25-1.81, P<0.001). CONCLUSION:Obesity increased the risk of severe disease, mortality and infection with COVID-19. Higher body mass index was associated with ICU admission and critical disease. Patients who are obese may be more susceptible to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, and infectedpatients should be monitored closely for adverse outcomes.
Authors: S Vivek Anand; Yao Kang Shuy; Poay Sian Sabrina Lee; Eng Sing Lee Journal: Int J Environ Res Public Health Date: 2021-08-30 Impact factor: 4.614
Authors: Christopher El Mouhayyar; Luke T Jaber; Matthias Bergmann; Hocine Tighiouart; Bertrand L Jaber Journal: Transbound Emerg Dis Date: 2021-11-09 Impact factor: 4.521
Authors: Antonis S Manolis; Antonis A Manolis; Theodora A Manolis; Naomi E Apostolaki; Helen Melita Journal: Obes Res Clin Pract Date: 2021-11-03 Impact factor: 2.288
Authors: Annukka A R Antar; Tong Yu; Nora Pisanic; Razvan Azamfirei; Jeffrey A Tornheim; Diane M Brown; Kate Kruczynski; Justin P Hardick; Thelio Sewell; Minyoung Jang; Taylor Church; Samantha N Walch; Carolyn Reuland; Vismaya S Bachu; Kirsten Littlefield; Han-Sol Park; Rebecca L Ursin; Abhinaya Ganesan; Oyinkansola Kusemiju; Brittany Barnaba; Curtisha Charles; Michelle Prizzi; Jaylynn R Johnstone; Christine Payton; Weiwei Dai; Joelle Fuchs; Guido Massaccesi; Derek T Armstrong; Jennifer L Townsend; Sara C Keller; Zoe O Demko; Chen Hu; Mei-Cheng Wang; Lauren M Sauer; Heba H Mostafa; Jeanne C Keruly; Shruti H Mehta; Sabra L Klein; Andrea L Cox; Andrew Pekosz; Christopher D Heaney; David L Thomas; Paul W Blair; Yukari C Manabe Journal: Open Forum Infect Dis Date: 2021-04-16 Impact factor: 3.835
Authors: Federica Barbagallo; Rosita A Condorelli; Laura M Mongioì; Rossella Cannarella; Laura Cimino; Maria Cristina Magagnini; Andrea Crafa; Sandro La Vignera; Aldo E Calogero Journal: Metabolites Date: 2021-12-04