Literature DB >> 3346184

Sch 37137, a novel antifungal compound produced by a Micromonospora sp. Taxonomy, fermentation, isolation, structure and biological properties.

R Cooper1, A C Horan, F Gentile, V Gullo, D Loebenberg, J Marquez, M Patel, M S Puar, I Truumees.   

Abstract

A new antifungal compound, Sch 37137, was isolated from the cultured broth of a Micromonospora sp., SCC 1792. Sch 37137 is structurally related to A 19009, a dipeptide previously discovered from a Streptomyces sp. The compound was weakly active against species of Candida and dermatophytes (mean MICs greater than or equal to 128 micrograms/ml) in Sabouraud dextrose, yeast-nitrogen and modified Eagles minimum essential media; however activity against Candida sp. (mean MICs greater than or equal to 12 micrograms/ml) and dermatophytes (mean MICs greater than or equal to 0.8 microgram/ml) significantly improved in MA medium.

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Year:  1988        PMID： 3346184     DOI： 10.7164/antibiotics.41.13

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN： 0021-8820            Impact factor:   2.649


  7 in total

Review 1.  The structural biology of enzymes involved in natural product glycosylation.

Authors:  Shanteri Singh; George N Phillips; Jon S Thorson
Journal:  Nat Prod Rep       Date:  2012-06-12       Impact factor: 13.423

2.  The nonribosomal peptide synthetase enzyme DdaD tethers N(β)-fumaramoyl-l-2,3-diaminopropionate for Fe(II)/α-ketoglutarate-dependent epoxidation by DdaC during dapdiamide antibiotic biosynthesis.

Authors:  Marie A Hollenhorst; Stefanie B Bumpus; Megan L Matthews; J Martin Bollinger; Neil L Kelleher; Christopher T Walsh
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3.  A head-to-head comparison of eneamide and epoxyamide inhibitors of glucosamine-6-phosphate synthase from the dapdiamide biosynthetic pathway.

Authors:  Marie A Hollenhorst; Ioanna Ntai; Bernard Badet; Neil L Kelleher; Christopher T Walsh
Journal:  Biochemistry       Date:  2011-04-26       Impact factor: 3.162

4.  2-amino-3-(oxirane-2,3-dicarboxamido)-propanoyl-valine, an effective peptide antibiotic from the epiphyte Pantoea agglomerans 48b/90.

Authors:  Ulrike F Sammer; Beate Völksch; Ute Möllmann; Michaela Schmidtke; Peter Spiteller; Michael Spiteller; Dieter Spiteller
Journal:  Appl Environ Microbiol       Date:  2009-10-09       Impact factor: 4.792

5.  The ATP-dependent amide ligases DdaG and DdaF assemble the fumaramoyl-dipeptide scaffold of the dapdiamide antibiotics.

Authors:  Marie A Hollenhorst; Jon Clardy; Christopher T Walsh
Journal:  Biochemistry       Date:  2009-11-03       Impact factor: 3.162

6.  Assessment of the relevance of the antibiotic 2-amino-3-(oxirane-2,3-dicarboxamido)-propanoyl-valine from Pantoea agglomerans biological control strains against bacterial plant pathogens.

Authors:  Ulrike F Sammer; Katharina Reiher; Dieter Spiteller; Annette Wensing; Beate Völksch
Journal:  Microbiologyopen       Date:  2012-10-30       Impact factor: 3.139

7.  Dapdiamides, tripeptide antibiotics formed by unconventional amide ligases.

Authors:  Jessica Dawlaty; Xiaorong Zhang; Michael A Fischbach; Jon Clardy
Journal:  J Nat Prod       Date:  2010-03-26       Impact factor: 4.050
  7 in total

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