Shanteri Singh1, George N Phillips, Jon S Thorson. 1. Laboratory for Biosynthetic Chemistry, Pharmaceutical Sciences Division, School of Pharmacy, University of Wisconsin-Madison, 777 Highland Avenue, Madison, WI 53705, USA.
Abstract
The glycosylation of microbial natural products often dramatically influences the biological and/or pharmacological activities of the parental metabolite. Over the past decade, crystal structures of several enzymes involved in the biosynthesis and attachment of novel sugars found appended to natural products have emerged. In many cases, these studies have paved the way to a better understanding of the corresponding enzyme mechanism of action and have served as a starting point for engineering variant enzymes to facilitate to production of differentially-glycosylated natural products. This review specifically summarizes the structural studies of bacterial enzymes involved in biosynthesis of novel sugar nucleotides.
The glycosylation of microbial natural products often dramatically influences the biological and/or pharmacological activities of the parental metabolite. Over the past decade, crystal structures of several enzymes involved in the biosynthen class="Chemical">sis and attachment of novel sugars found appended to natural products have emerged. In many cases, these studies have paved the way to a better understanding of the corresponding enzyme mechanism of action and have served as a starting point for engineering variant enzymes to facilitate to production of differentially-glycosylated natural products. This review specifically summarizes the structural studies of bacterial enzymes involved in biosynthesis of novel sugar nucleotides.
Authors: William A Barton; John B Biggins; Jiqing Jiang; Jon S Thorson; Dimitar B Nikolov Journal: Proc Natl Acad Sci U S A Date: 2002-10-08 Impact factor: 11.205
Authors: Ian C Schoenhofen; Vladimir V Lunin; Jean-Philippe Julien; Yunge Li; Eunice Ajamian; Allan Matte; Miroslaw Cygler; Jean-Robert Brisson; Annie Aubry; Susan M Logan; Smita Bhatia; Warren W Wakarchuk; N Martin Young Journal: J Biol Chem Date: 2006-01-18 Impact factor: 5.157
Authors: Sarathy Karunan Partha; Ali Sadeghi-Khomami; Kathryn Slowski; Toshihisa Kotake; Neil R Thomas; David L Jakeman; David A R Sanders Journal: J Mol Biol Date: 2010-09-17 Impact factor: 5.469
Authors: Heng Keat Tam; Johannes Härle; Stefan Gerhardt; Jürgen Rohr; Guojun Wang; Jon S Thorson; Aurélien Bigot; Monika Lutterbeck; Wolfgang Seiche; Bernhard Breit; Andreas Bechthold; Oliver Einsle Journal: Angew Chem Int Ed Engl Date: 2015-01-07 Impact factor: 15.336
Authors: Fengbin Wang; Shanteri Singh; Weijun Xu; Kate E Helmich; Mitchell D Miller; Hongnan Cao; Craig A Bingman; Jon S Thorson; George N Phillips Journal: ACS Chem Biol Date: 2015-06-23 Impact factor: 5.100
Authors: Richard W Gantt; Pauline Peltier-Pain; Shanteri Singh; Maoquan Zhou; Jon S Thorson Journal: Proc Natl Acad Sci U S A Date: 2013-04-22 Impact factor: 11.205
Authors: Roland D Kersten; Nadine Ziemert; David J Gonzalez; Brendan M Duggan; Victor Nizet; Pieter C Dorrestein; Bradley S Moore Journal: Proc Natl Acad Sci U S A Date: 2013-11-04 Impact factor: 11.205
Authors: Jianjun Zhang; Larissa V Ponomareva; Karen Marchillo; Maoquan Zhou; David R Andes; Jon S Thorson Journal: J Nat Prod Date: 2013-08-29 Impact factor: 4.050