Lian Tan1,2, Yanling Long1,2, Ziyang Li1,2, Xi Ying1,2, Jiayun Ren1,2, Cheng Sun1,2, Xiaohong Meng3,4, Shiying Li5,6. 1. Southwest Eye Hospital/Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, 400038, China. 2. Key Lab of Visual Damage and Regeneration & Restoration of Chongqing, Chongqing, 400038, China. 3. Southwest Eye Hospital/Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, 400038, China. cqwmwm@163.com. 4. Key Lab of Visual Damage and Regeneration & Restoration of Chongqing, Chongqing, 400038, China. cqwmwm@163.com. 5. Southwest Eye Hospital/Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, 400038, China. shiying_li@126.com. 6. Key Lab of Visual Damage and Regeneration & Restoration of Chongqing, Chongqing, 400038, China. shiying_li@126.com.
Abstract
BACKGROUND: To report the prevalence of ocular abnormalities and investigate visual acuity in a large cohort of retinitis pigmentosa (RP) patients in Western China. METHODS: The medical records and ophthalmic examination reports of 2127 eyes of 1065 RP patients at one eye hospital were retrospectively reviewed to determined the prevalence of ocular abnormalities and the relationship between best corrected visual acuity (BCVA) and macular abnormalities. RESULTS: Nyctalopia (58.2%) and blurred vision (27.1%) were the leading reasons for RP patients to request an ophthalmic examination. BCVA measurements in the better eyes at first clinical presentation showed that 304 patients (28.5%) were categorised as blind and 220 patients (20.7%) as low vision. The most common ocular abnormalities were macular abnormalities (59.7%) and cataracts (43.1%). The macular abnormalities included epiretinal membranes (51.1%), cystoid macular edema (18.4%), vitreomacular traction syndrome (2.4%), macular holes (2.3%) and choroidal neovascular membranes (0.05%). Glaucoma was found in 35 eyes (1.6%). The proportions of epiretinal membranes (p = 0.001) and macular holes (p = 0.008) increased significantly with age. Cystoid macular edema was significantly associated with poorer visual acuity in RP patients with clear lens (p = 0.002). CONCLUSION: Cataracts and macular abnormalities are common in RP patients. Of the macular abnormalities, cystoid macular edema may have a negative effect on BCVA in RP patients with clear lens. Therefore, optical coherence tomography screening in RP patients is highly recommended for early detection and treatment of maculopathy.
BACKGROUND: To report the prevalence of ocular abnormalities and investigate visual acuity in a large cohort of retinitis pigmentosa (RP) patients in Western China. METHODS: The medical records and ophthalmic examination reports of 2127 eyes of 1065 RP patients at one eye hospital were retrospectively reviewed to determined the prevalence of ocular abnormalities and the relationship between best corrected visual acuity (BCVA) and macular abnormalities. RESULTS: Nyctalopia (58.2%) and blurred vision (27.1%) were the leading reasons for RP patients to request an ophthalmic examination. BCVA measurements in the better eyes at first clinical presentation showed that 304 patients (28.5%) were categorised as blind and 220 patients (20.7%) as low vision. The most common ocular abnormalities were macular abnormalities (59.7%) and cataracts (43.1%). The macular abnormalities included epiretinal membranes (51.1%), cystoid macular edema (18.4%), vitreomacular traction syndrome (2.4%), macular holes (2.3%) and choroidal neovascular membranes (0.05%). Glaucoma was found in 35 eyes (1.6%). The proportions of epiretinal membranes (p = 0.001) and macular holes (p = 0.008) increased significantly with age. Cystoid macular edema was significantly associated with poorer visual acuity in RP patients with clear lens (p = 0.002). CONCLUSION:Cataracts and macular abnormalities are common in RP patients. Of the macular abnormalities, cystoid macular edema may have a negative effect on BCVA in RP patients with clear lens. Therefore, optical coherence tomography screening in RP patients is highly recommended for early detection and treatment of maculopathy.
Authors: Lorena Fernández-Martínez; Stef Letteboer; Christian Y Mardin; Nicole Weisschuh; Eugen Gramer; Bernhard Hf Weber; Bernd Rautenstrauss; Paulo A Ferreira; Friedrich E Kruse; André Reis; Ronald Roepman; Francesca Pasutto Journal: Eur J Hum Genet Date: 2011-01-12 Impact factor: 4.246
Authors: Saba Al Rashaed; Arif O Khan; Sawsan R Nowilaty; Deepak P Edward; Igor Kozak Journal: Graefes Arch Clin Exp Ophthalmol Date: 2015-04-22 Impact factor: 3.117
Authors: Gerald Liew; Anthony T Moore; Patrick D Bradley; Andrew R Webster; Michel Michaelides Journal: Ophthalmic Epidemiol Date: 2017-11-15 Impact factor: 1.648