Gerald Liew1,2, Anthony T Moore1,2,3, Patrick D Bradley2, Andrew R Webster2,4, Michel Michaelides2,4. 1. a Centre for Vision Research, Westmead Institute for Medical Research , University of Sydney , Sydney , Australia. 2. b Department of Ophthalmology, Moorfields Eye Hospital , London , UK. 3. d Department of Ophthalmology, UCSF School of Medicine, San Francisco, California, USA. 4. c Institute of Ophthalmology , University College London , London , UK.
Abstract
PURPOSE: Retinitis pigmentosa is the most common inherited retinal dystrophy. The factors associated with visual acuity in patients with other retinal diseases are well known, but are poorly understood in patients with retinitis pigmentosa. This knowledge is useful for prognosis and to support secondary endpoints in clinical trials. METHODS: We conducted a cross-sectional study of consecutive patients recruited from the inherited retinal disease service from January 2012 to December 2012. Central macular thickness (CMT) was measured using spectral domain optical coherence tomography. RESULTS: Data were available for 81 patients and 162 eyes. After multivariable analyses, older age, earlier age of onset of symptoms, and thicker CMT were associated with lower visual acuity. Gender and inheritance pattern were not associated with visual acuity. Each decade older age, younger age of onset, and thicker CMT was associated with 0.12, 0.10, and 0.11 worse logarithm of the minimal angle of resolution units of visual acuity, respectively (p < 0.05 for all). CONCLUSIONS: Age, age of onset, and CMT are associated with visual acuity and important factors to measure in studies of retinitis pigmentosa.
PURPOSE:Retinitis pigmentosa is the most common inherited retinal dystrophy. The factors associated with visual acuity in patients with other retinal diseases are well known, but are poorly understood in patients with retinitis pigmentosa. This knowledge is useful for prognosis and to support secondary endpoints in clinical trials. METHODS: We conducted a cross-sectional study of consecutive patients recruited from the inherited retinal disease service from January 2012 to December 2012. Central macular thickness (CMT) was measured using spectral domain optical coherence tomography. RESULTS: Data were available for 81 patients and 162 eyes. After multivariable analyses, older age, earlier age of onset of symptoms, and thicker CMT were associated with lower visual acuity. Gender and inheritance pattern were not associated with visual acuity. Each decade older age, younger age of onset, and thicker CMT was associated with 0.12, 0.10, and 0.11 worse logarithm of the minimal angle of resolution units of visual acuity, respectively (p < 0.05 for all). CONCLUSIONS: Age, age of onset, and CMT are associated with visual acuity and important factors to measure in studies of retinitis pigmentosa.
Authors: Rosa M Coco-Martin; Miguel Diego-Alonso; W Andres Orduz-Montaña; M Rosa Sanabria; Hortensia Sanchez-Tocino Journal: Clin Ophthalmol Date: 2021-03-09