Kelly R Tan1, Sheila J Santacroce1,2, William A Wood2,3, Deborah K Mayer1,2, Hudson Santos1, Peter J Mucha4, Todd A Schwartz1,5, Barbara L Fredrickson2,6. 1. School of Nursing, University of North Carolina, Chapel Hill, North Carolina, USA. 2. Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina, USA. 3. Division of Hematology/Oncology, Department of Medicine, University of North Carolina, Chapel Hill, North Carolina, USA. 4. Department of Mathematics and Applied Physical Sciences, University of North Carolina, Chapel Hill, North Carolina, USA. 5. Department of Biostatistics, University of North Carolina, Chapel Hill, North Carolina, USA. 6. Department Of Psychology and Neuroscience, University of North Carolina, Chapel Hill, North Carolina, USA.
Abstract
AIMS: This protocol directs a study that aims to: (a) describe the caregiver's experience over 8-12 weeks after an index adult patient's allogeneic bone marrow transplant (BMT) for advanced cancer using a case-oriented approach and mixed methods, with qualitative methods in the foreground; and (b) explore networks of relationships among psycho-neurological symptoms, positive psychological states and caregiver health. DESIGN: Case-oriented longitudinal design using multiple data types and analytic approaches. METHODS: Data will be collected from 10-12 caregivers. The sample will be recruited from a large public hospital in the southeastern United States using maximum variation sampling (e.g., caregiver race/ethnicity, relationship to patient, age, education, and number of caregiving roles). Participants will be asked to complete weekly surveys, have their blood drawn bi-weekly and participate in an interview each month during the study period (~100 days). Aim 1 analysis will include directed content analysis and case-oriented visual analysis. Aim 2 analysis will include symptom network estimation of psycho-neurological symptoms, positive psychological states, and caregiver health. Institutional review board approval was obtained August 2018. DISCUSSION: Results will provide an in-depth description of caregivers' experiences in the 100 days after BMT. Findings will inform generation of hypotheses and identification of targets for interventions to improve caregiver's experiences after BMT. IMPACT: This in-depth multi-method longitudinal study to describe caregivers of adult patients receiving an allogeneic BMT is an essential step in understanding caregivers' complex responses to chronic stress and the role of positive psychological states. The results from this study will inform future research on chronic stress processes, intense caregiving, and intervention development.
AIMS: This protocol directs a study that aims to: (a) describe the caregiver's experience over 8-12 weeks after an index adult patient's allogeneic bone marrow transplant (BMT) for advanced cancer using a case-oriented approach and mixed methods, with qualitative methods in the foreground; and (b) explore networks of relationships among psycho-neurological symptoms, positive psychological states and caregiver health. DESIGN: Case-oriented longitudinal design using multiple data types and analytic approaches. METHODS: Data will be collected from 10-12 caregivers. The sample will be recruited from a large public hospital in the southeastern United States using maximum variation sampling (e.g., caregiver race/ethnicity, relationship to patient, age, education, and number of caregiving roles). Participants will be asked to complete weekly surveys, have their blood drawn bi-weekly and participate in an interview each month during the study period (~100 days). Aim 1 analysis will include directed content analysis and case-oriented visual analysis. Aim 2 analysis will include symptom network estimation of psycho-neurological symptoms, positive psychological states, and caregiver health. Institutional review board approval was obtained August 2018. DISCUSSION: Results will provide an in-depth description of caregivers' experiences in the 100 days after BMT. Findings will inform generation of hypotheses and identification of targets for interventions to improve caregiver's experiences after BMT. IMPACT: This in-depth multi-method longitudinal study to describe caregivers of adult patients receiving an allogeneic BMT is an essential step in understanding caregivers' complex responses to chronic stress and the role of positive psychological states. The results from this study will inform future research on chronic stress processes, intense caregiving, and intervention development.
Authors: M S Corrêa; K Vedovelli; B L Giacobbo; C E B de Souza; P Ferrari; I I de Lima Argimon; J C Walz; F Kapczinski; E Bromberg Journal: Neuroscience Date: 2014-12-06 Impact factor: 3.590
Authors: Teresa L Simoneau; Susan K Mikulich-Gilbertson; Crystal Natvig; Kristin Kilbourn; Janet Spradley; Rachel Grzywa-Cobb; Samuel Philips; Peter McSweeney; Mark L Laudenslager Journal: Psychooncology Date: 2013-02-25 Impact factor: 3.894