Literature DB >> 33457378

Is Persistent Thick Copious Mucus a Long-Term Symptom of COVID-19?

Patrick Manckoundia1,2, Evelyne Franon3.   

Abstract

INTRODUCTION: The typical clinical picture of COVID-19 is gradually becoming clearer, both in the acute phase and in the long-term. However, new symptoms are gradually being identified. We describe a long-term symptom that has not yet been reported. CASE DESCRIPTION: A 49-year-old man consulted for persistent asthenia. The general practitioner found a fever (39.2°C), and COVID-19 was confirmed by the polymerase chain reaction test. Further symptoms appeared, notably thick, white, painless tracheal hypersecretion for 3 months before diminishing, without disappearing.
CONCLUSION: Non-inflammatory tracheal hypersecretion, not yet reported in COVID-19, may be an additional long-term symptom. The hyperstimulation of tracheal goblet cells secreting mucus is 1 pathophysiological hypothesis. LEARNING POINTS: Painless, non-inflammatory tracheal hypersecretion, which has yet to be described in post-acute COVID-19, may be an additional long-term symptom of the disease.The hyperstimulation of mucus-secreting tracheal goblet cells by the coronavirus, leading to tracheal discomfort and a feeling of suffocation, is 1 pathophysiological hypothesis. © EFIM 2020.

Entities:  

Keywords:  COVID-19; long-term symptom; tracheal hypersecretion

Year:  2020        PMID: 33457378      PMCID: PMC7806295          DOI: 10.12890/2020_002145

Source DB:  PubMed          Journal:  Eur J Case Rep Intern Med        ISSN: 2284-2594


  11 in total

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Authors:  Sumanta Mukherjee; Dennis M Lindell; Aaron A Berlin; Susan B Morris; Thomas P Shanley; Marc B Hershenson; Nicholas W Lukacs
Journal:  Am J Pathol       Date:  2011-05-03       Impact factor: 4.307

2.  Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China.

Authors:  Chaolin Huang; Yeming Wang; Xingwang Li; Lili Ren; Jianping Zhao; Yi Hu; Li Zhang; Guohui Fan; Jiuyang Xu; Xiaoying Gu; Zhenshun Cheng; Ting Yu; Jiaan Xia; Yuan Wei; Wenjuan Wu; Xuelei Xie; Wen Yin; Hui Li; Min Liu; Yan Xiao; Hong Gao; Li Guo; Jungang Xie; Guangfa Wang; Rongmeng Jiang; Zhancheng Gao; Qi Jin; Jianwei Wang; Bin Cao
Journal:  Lancet       Date:  2020-01-24       Impact factor: 79.321

3.  Olfactory and gustatory dysfunctions as a clinical presentation of mild-to-moderate forms of the coronavirus disease (COVID-19): a multicenter European study.

Authors:  Jerome R Lechien; Carlos M Chiesa-Estomba; Daniele R De Siati; Mihaela Horoi; Serge D Le Bon; Alexandra Rodriguez; Didier Dequanter; Serge Blecic; Fahd El Afia; Lea Distinguin; Younes Chekkoury-Idrissi; Stéphane Hans; Irene Lopez Delgado; Christian Calvo-Henriquez; Philippe Lavigne; Chiara Falanga; Maria Rosaria Barillari; Giovanni Cammaroto; Mohamad Khalife; Pierre Leich; Christel Souchay; Camelia Rossi; Fabrice Journe; Julien Hsieh; Myriam Edjlali; Robert Carlier; Laurence Ris; Andrea Lovato; Cosimo De Filippis; Frederique Coppee; Nicolas Fakhry; Tareck Ayad; Sven Saussez
Journal:  Eur Arch Otorhinolaryngol       Date:  2020-04-06       Impact factor: 2.503

4.  Pulmonary post-mortem findings in a series of COVID-19 cases from northern Italy: a two-centre descriptive study.

Authors:  Luca Carsana; Aurelio Sonzogni; Ahmed Nasr; Roberta Simona Rossi; Alessandro Pellegrinelli; Pietro Zerbi; Roberto Rech; Riccardo Colombo; Spinello Antinori; Mario Corbellino; Massimo Galli; Emanuele Catena; Antonella Tosoni; Andrea Gianatti; Manuela Nebuloni
Journal:  Lancet Infect Dis       Date:  2020-06-08       Impact factor: 25.071

5.  Clinical Characteristics of Coronavirus Disease 2019 in China.

Authors:  Wei-Jie Guan; Zheng-Yi Ni; Yu Hu; Wen-Hua Liang; Chun-Quan Ou; Jian-Xing He; Lei Liu; Hong Shan; Chun-Liang Lei; David S C Hui; Bin Du; Lan-Juan Li; Guang Zeng; Kwok-Yung Yuen; Ru-Chong Chen; Chun-Li Tang; Tao Wang; Ping-Yan Chen; Jie Xiang; Shi-Yue Li; Jin-Lin Wang; Zi-Jing Liang; Yi-Xiang Peng; Li Wei; Yong Liu; Ya-Hua Hu; Peng Peng; Jian-Ming Wang; Ji-Yang Liu; Zhong Chen; Gang Li; Zhi-Jian Zheng; Shao-Qin Qiu; Jie Luo; Chang-Jiang Ye; Shao-Yong Zhu; Nan-Shan Zhong
Journal:  N Engl J Med       Date:  2020-02-28       Impact factor: 91.245

6.  Alveolar macrophage dysfunction and cytokine storm in the pathogenesis of two severe COVID-19 patients.

Authors:  Chaofu Wang; Jing Xie; Lei Zhao; Xiaochun Fei; Heng Zhang; Yun Tan; Xiu Nie; Luting Zhou; Zhenhua Liu; Yong Ren; Ling Yuan; Yu Zhang; Jinsheng Zhang; Liwei Liang; Xinwei Chen; Xin Liu; Peng Wang; Xiao Han; Xiangqin Weng; Ying Chen; Ting Yu; Xinxin Zhang; Jun Cai; Rong Chen; Zheng-Li Shi; Xiu-Wu Bian
Journal:  EBioMedicine       Date:  2020-06-20       Impact factor: 8.143

7.  Postmortem examination of COVID-19 patients reveals diffuse alveolar damage with severe capillary congestion and variegated findings in lungs and other organs suggesting vascular dysfunction.

Authors:  Thomas Menter; Jasmin D Haslbauer; Ronny Nienhold; Spasenija Savic; Helmut Hopfer; Nikolaus Deigendesch; Stephan Frank; Daniel Turek; Niels Willi; Hans Pargger; Stefano Bassetti; Joerg D Leuppi; Gieri Cathomas; Markus Tolnay; Kirsten D Mertz; Alexandar Tzankov
Journal:  Histopathology       Date:  2020-07-05       Impact factor: 5.087

8.  Gastrointestinal symptoms of 95 cases with SARS-CoV-2 infection.

Authors:  Lu Lin; Xiayang Jiang; Zhenling Zhang; Siwen Huang; Zhenyi Zhang; Zhaoxiong Fang; Zhiqiang Gu; Liangqing Gao; Honggang Shi; Lei Mai; Yuan Liu; Xianqi Lin; Renxu Lai; Zhixiang Yan; Xiaofeng Li; Hong Shan
Journal:  Gut       Date:  2020-04-02       Impact factor: 23.059

9.  Airway Hygiene in COVID-19 Pneumonia: Treatment Responses of 3 Critically Ill Cruise Ship Employees.

Authors:  Faryal I Farooqi; Richard C Morgan; Naveen Dhawan; John Dinh; George Yatzkan; George Michel
Journal:  Am J Case Rep       Date:  2020-08-18

Review 10.  Coronavirus: Update Related to the Current Outbreak of COVID-19.

Authors:  Giovanni Gabutti; Erica d'Anchera; Federica Sandri; Marta Savio; Armando Stefanati
Journal:  Infect Dis Ther       Date:  2020-04-08
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  3 in total

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Authors:  Hossein Estiri; Zachary H Strasser; Gabriel A Brat; Yevgeniy R Semenov; Chirag J Patel; Shawn N Murphy
Journal:  BMC Med       Date:  2021-09-27       Impact factor: 11.150

2.  Genetic alterations, RNA expression profiling and DNA methylation of HMGB1 in malignancies.

Authors:  Shoukai Yu; Lingmei Qian; Jun Ma
Journal:  J Cell Mol Med       Date:  2022-06-28       Impact factor: 5.295

3.  Challenges in defining Long COVID: Striking differences across literature, Electronic Health Records, and patient-reported information.

Authors:  Halie M Rando; Tellen D Bennett; James Brian Byrd; Carolyn Bramante; Tiffany J Callahan; Christopher G Chute; Hannah E Davis; Rachel Deer; Joel Gagnier; Farrukh M Koraishy; Feifan Liu; Julie A McMurry; Richard A Moffitt; Emily R Pfaff; Justin T Reese; Rose Relevo; Peter N Robinson; Joel H Saltz; Anthony Solomonides; Anupam Sule; Umit Topaloglu; Melissa A Haendel
Journal:  medRxiv       Date:  2021-03-26
  3 in total

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