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Literature DB >> 33456561

N⁶-methyladenosine as a biological and clinical determinant in colorectal cancer: progression and future direction.

Jinming Li^1,2, Lei Liang^1,2, Yongzhi Yang^1,2, Xinxiang Li^1,2, Yanlei Ma^1,2.

Abstract

Colorectal cancer (CRC) is one of the most prevalent cancers and one of the leading causes of cancer death. Recent studies have provided evidence that N6-methyladenosine (m6A), the most abundant RNA modifications in eukaryote, performs many functions in RNA metabolism including translation, splicing, storage, trafficking and degradation. Aberrant regulation of m6A modification in mRNAs and noncoding RNAs found in CRC tissues is crucial for cancer formation, progression, invasion and metastasis. Further, m6A regulators and m6A-related RNAs may become promising biomarkers, prognosis predictors as well as therapeutic targets. Here, we review the biological and clinical roles of m6A modification in CRC, and discuss the potential of m6A in clinical translation. © The author(s).

Entities: Chemical Disease Gene Mutation Species

Keywords: RNA modification; cancer progression; cancer treatment; colorectal cancer; m6A

Year: 2021 PMID： 33456561 PMCID： PMC7806471 DOI： 10.7150/thno.52366

Source DB: PubMed Journal: Theranostics ISSN： 1838-7640 Impact factor: 11.556

121 in total

Review 1. Unique features of long non-coding RNA biogenesis and function.

Authors: Jeffrey J Quinn; Howard Y Chang
Journal: Nat Rev Genet Date: 2016-01 Impact factor: 53.242

2. Comprehensive analysis of mRNA methylation reveals enrichment in 3' UTRs and near stop codons.

Authors: Kate D Meyer; Yogesh Saletore; Paul Zumbo; Olivier Elemento; Christopher E Mason; Samie R Jaffrey
Journal: Cell Date: 2012-05-17 Impact factor: 41.582

3. RNA helicase YTHDC2 promotes cancer metastasis via the enhancement of the efficiency by which HIF-1α mRNA is translated.

Authors: Atsushi Tanabe; Kenya Tanikawa; Mai Tsunetomi; Kaori Takai; Hiroto Ikeda; Junpei Konno; Toshihiko Torigoe; Hideki Maeda; Goro Kutomi; Kenji Okita; Mitsuru Mori; Hiroeki Sahara
Journal: Cancer Lett Date: 2016-03-17 Impact factor: 8.679

4. Association between FTO gene polymorphism (rs9939609 T/A) and cancer risk: a meta-analysis.

Authors: Xiaoyi Huang; Jian Zhao; Mingyuan Yang; Ming Li; Jianming Zheng
Journal: Eur J Cancer Care (Engl) Date: 2016-03-01 Impact factor: 2.520

Review 5. The Influence of the Gut Microbiome on Cancer, Immunity, and Cancer Immunotherapy.

Authors: Vancheswaran Gopalakrishnan; Beth A Helmink; Christine N Spencer; Alexandre Reuben; Jennifer A Wargo
Journal: Cancer Cell Date: 2018-04-09 Impact factor: 31.743

6. Single-nucleotide-resolution mapping of m6A and m6Am throughout the transcriptome.

Authors: Bastian Linder; Anya V Grozhik; Anthony O Olarerin-George; Cem Meydan; Christopher E Mason; Samie R Jaffrey
Journal: Nat Methods Date: 2015-06-29 Impact factor: 28.547

7. Zc3h13/Flacc is required for adenosine methylation by bridging the mRNA-binding factor Rbm15/Spenito to the m⁶A machinery component Wtap/Fl(2)d.

Authors: Philip Knuckles; Tina Lence; Irmgard U Haussmann; Dominik Jacob; Nastasja Kreim; Sarah H Carl; Irene Masiello; Tina Hares; Rodrigo Villaseñor; Daniel Hess; Miguel A Andrade-Navarro; Marco Biggiogera; Mark Helm; Matthias Soller; Marc Bühler; Jean-Yves Roignant
Journal: Genes Dev Date: 2018-03-13 Impact factor: 11.361

8. Oncogene c-Myc promotes epitranscriptome m⁶A reader YTHDF1 expression in colorectal cancer.

Authors: Yujiro Nishizawa; Masamitsu Konno; Ayumu Asai; Jun Koseki; Koichi Kawamoto; Norikatsu Miyoshi; Hidekazu Takahashi; Naohiro Nishida; Naotsugu Haraguchi; Daisuke Sakai; Toshihiro Kudo; Taishi Hata; Chu Matsuda; Tsunekazu Mizushima; Taroh Satoh; Yuichiro Doki; Masaki Mori; Hideshi Ishii
Journal: Oncotarget Date: 2017-12-21

9. DART-seq: an antibody-free method for global m⁶A detection.

Authors: Kate D Meyer
Journal: Nat Methods Date: 2019-09-23 Impact factor: 28.547

10. RNA cytosine methylation by Dnmt2 and NSun2 promotes tRNA stability and protein synthesis.

Authors: Francesca Tuorto; Reinhard Liebers; Tanja Musch; Matthias Schaefer; Sarah Hofmann; Stefanie Kellner; Michaela Frye; Mark Helm; Georg Stoecklin; Frank Lyko
Journal: Nat Struct Mol Biol Date: 2012-08-12 Impact factor: 15.369

13 in total

Review 1. N6-methyladenosine RNA modification and its interaction with regulatory non-coding RNAs in colorectal cancer.

Authors: Yiling Ge; Tong Liu; Chuntao Wang; Yanqiu Zhang; Siyi Xu; Yiyi Ren; Yanlu Feng; Lihong Yin; Yuepu Pu; Geyu Liang
Journal: RNA Biol Date: 2021-10-21 Impact factor: 4.766

2. N6-methyladenosine-induced circ1662 promotes metastasis of colorectal cancer by accelerating YAP1 nuclear localization.

Authors: Chen Chen; Weitang Yuan; Quanbo Zhou; Bo Shao; Yuying Guo; Weiwei Wang; Shuaixi Yang; Yaxin Guo; Luyang Zhao; Qin Dang; Xiuxiu Yang; Guixian Wang; Qiaozhen Kang; Zhenyu Ji; Jinbo Liu; Zhenqiang Sun
Journal: Theranostics Date: 2021-02-25 Impact factor: 11.556

3. Comprehensive Analysis of N6-Methyladenosine-Related lncRNA Signature for Predicting Prognosis and Immune Cell Infiltration in Patients with Colorectal Cancer.

Authors: Zhan Zhao; Ya-Bing Yang; Xin-Yuan Li; Xu-Guang Li; Xiao-Dong Chu; Zheng-Bin Lin; Yi-Ran Zhang; Yan-Guan Guo; Hui Ding; Yun-Long Pan; Liang Wang; Jing-Hua Pan
Journal: Dis Markers Date: 2021-10-28 Impact factor: 3.434

4. Analysis of N⁶-Methyladenosine Methylome in Adenocarcinoma of Esophagogastric Junction.

Authors: Jia-Bin Huang; Bin-Bin Hu; Rong He; Lian He; Chen Zou; Chang-Feng Man; Yu Fan
Journal: Front Genet Date: 2022-01-24 Impact factor: 4.599

5. Molecular Characteristics, Oncogenic Roles, and Relevant Immune and Pharmacogenomic Features of EVA1B in Colorectal Cancer.

Authors: Bin Ma; Kangchun Wang; Yu Liang; Qingkai Meng; Yongmin Li
Journal: Front Immunol Date: 2022-02-16 Impact factor: 7.561

6. Exploration of Potential Roles of m5C-Related Regulators in Colon Adenocarcinoma Prognosis.

Authors: Yuancheng Huang; Chaoyuan Huang; Xiaotao Jiang; Yanhua Yan; Kunhai Zhuang; Fengbin Liu; Peiwu Li; Yi Wen
Journal: Front Genet Date: 2022-02-24 Impact factor: 4.599

7. An N⁶-methyladenosine-associated lncRNA signature for predicting clinical outcome and therapeutic responses in hepatocellular carcinoma.

Authors: Danjun Song; Yingming Tian; Jun Luo; Guoliang Shao; Jiaping Zheng
Journal: Ann Transl Med Date: 2022-04

N⁶-methyladenosine as a biological and clinical determinant in colorectal cancer: progression and future direction.

Review 1. Unique features of long non-coding RNA biogenesis and function.

2. Comprehensive analysis of mRNA methylation reveals enrichment in 3' UTRs and near stop codons.

3. RNA helicase YTHDC2 promotes cancer metastasis via the enhancement of the efficiency by which HIF-1α mRNA is translated.

4. Association between FTO gene polymorphism (rs9939609 T/A) and cancer risk: a meta-analysis.

Review 5. The Influence of the Gut Microbiome on Cancer, Immunity, and Cancer Immunotherapy.

6. Single-nucleotide-resolution mapping of m6A and m6Am throughout the transcriptome.

7. Zc3h13/Flacc is required for adenosine methylation by bridging the mRNA-binding factor Rbm15/Spenito to the m⁶A machinery component Wtap/Fl(2)d.

8. Oncogene c-Myc promotes epitranscriptome m⁶A reader YTHDF1 expression in colorectal cancer.

9. DART-seq: an antibody-free method for global m⁶A detection.

10. RNA cytosine methylation by Dnmt2 and NSun2 promotes tRNA stability and protein synthesis.

Review 1. N6-methyladenosine RNA modification and its interaction with regulatory non-coding RNAs in colorectal cancer.

2. N6-methyladenosine-induced circ1662 promotes metastasis of colorectal cancer by accelerating YAP1 nuclear localization.

3. Comprehensive Analysis of N6-Methyladenosine-Related lncRNA Signature for Predicting Prognosis and Immune Cell Infiltration in Patients with Colorectal Cancer.

4. Analysis of N⁶-Methyladenosine Methylome in Adenocarcinoma of Esophagogastric Junction.

5. Molecular Characteristics, Oncogenic Roles, and Relevant Immune and Pharmacogenomic Features of EVA1B in Colorectal Cancer.

6. Exploration of Potential Roles of m5C-Related Regulators in Colon Adenocarcinoma Prognosis.

7. An N⁶-methyladenosine-associated lncRNA signature for predicting clinical outcome and therapeutic responses in hepatocellular carcinoma.

Review 8. The role of m6A methylation in osteosarcoma biological processes and its potential clinical value.

9. Genome-Wide Identification of m6A-Associated Single-Nucleotide Polymorphisms in Colorectal Cancer.

Review 10. N⁶-methyladenosine (m⁶A) in pancreatic cancer: Regulatory mechanisms and future direction.

Review 1. Unique features of long non-coding RNA biogenesis and function.

Review 5. The Influence of the Gut Microbiome on Cancer, Immunity, and Cancer Immunotherapy.

Review 1. N6-methyladenosine RNA modification and its interaction with regulatory non-coding RNAs in colorectal cancer.

Review 8. The role of m6A methylation in osteosarcoma biological processes and its potential clinical value.

Review 10. N6-methyladenosine (m6A) in pancreatic cancer: Regulatory mechanisms and future direction.

Review 10. N⁶-methyladenosine (m⁶A) in pancreatic cancer: Regulatory mechanisms and future direction.