Literature DB >> 3345610

Inhibition of liver tumor cell colonization in two animal tumor models by lectin blocking with D-galactose or arabinogalactan.

J Beuth1, H L Ko, V Schirrmacher, G Uhlenbruck, G Pulverer.   

Abstract

Repeated administration of the hepatic lectin blocking agents D-galactose or arabinogalactan completely prevented the settling of metastatic cells of sarcoma L-1 tumor in the liver of Balb/c mice and greatly reduced the colonization process of highly metastatic ESb lymphoma cells of the liver of DBA/2 mice. Therefore, when hepatic lectins were blocked with competitive glycoconjugates, tumor cell colonization of the liver could be prevented in two different model systems.

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Year:  1988        PMID： 3345610     DOI： 10.1007/bf01784842

Source DB:  PubMed          Journal:  Clin Exp Metastasis        ISSN： 0262-0898            Impact factor:   5.150


  22 in total

1.  Macrophages and metastasis--a biological approach to cancer therapy.

Authors:  I J Fidler
Journal:  Cancer Res       Date:  1985-10       Impact factor: 12.701

2.  Inhibition of liver metastasis in mice by blocking hepatocyte lectins with arabinogalactan infusions and D-galactose.

Authors:  J Beuth; H L Ko; K Oette; G Pulverer; K Roszkowski; G Uhlenbruck
Journal:  J Cancer Res Clin Oncol       Date:  1987       Impact factor: 4.553

Review 3.  [Lectins and the organotropy of metastasis].

Authors:  G Uhlenbruck; H J Beuth; K Oette; T Schotten; H L Ko; K Roszkowski; W Roszkowski; R Lütticken; G Pulverer
Journal:  Dtsch Med Wochenschr       Date:  1986-06-20       Impact factor: 0.628

4.  Differential expression of endogenous lectins on the surface of nontumorigenic, tumorigenic, and metastatic cells.

Authors:  A Raz; L Meromsky; R Lotan
Journal:  Cancer Res       Date:  1986-07       Impact factor: 12.701

5.  Tumor metastases and cell-mediated immunity in a model system in DBA/2 mice. I. Tumor invasiveness in vitro and metastasis formation in vivo.

Authors:  V Schirrmacher; G Shantz; K Clauer; D Komitowski; H P Zimmermann; M L Lohmann-Matthes
Journal:  Int J Cancer       Date:  1979-02       Impact factor: 7.396

6.  Proposed molecular basis of murine tumor cell-hepatocyte interaction.

Authors:  G F Springer; R Cheingsong-Popov; V Schirrmacher; P R Desai; H Tegtmeyer
Journal:  J Biol Chem       Date:  1983-05-10       Impact factor: 5.157

7.  Murine lymphoma cells possess blood group Tn-, T-, N-, M- and S-active substances.

Authors:  G F Springer; P R Desai; H Tegtmeyer; V Schirmacher; R Cheingsong-Popov
Journal:  Naturwissenschaften       Date:  1983-02

8.  Galactosyl specific receptor on liver cells: binding site for tumor cells.

Authors:  J Schlepper-Schäfer; E Friedrich; H Kolb
Journal:  Eur J Cell Biol       Date:  1981-08       Impact factor: 4.492

9.  Endogenous tumor lectins: a new class of tumor markers and targets for therapy?

Authors:  H J Gabius; R Engelhardt; F Cramer
Journal:  Med Hypotheses       Date:  1985-09       Impact factor: 1.538

10.  Differential expression of endogenous sugar-binding proteins (lectins) in murine tumor model systems with metastatic capacity.

Authors:  H J Gabius; G Bandlow; V Schirrmacher; G A Nagel; K Vehmeyer
Journal:  Int J Cancer       Date:  1987-05-15       Impact factor: 7.396
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  7 in total

1.  Glycoprotein modifications of sarcoma L-1 tumor cells by tunicamycin, swainsonine, bromoconduritol or 1-desoxynojirimycin treatment inhibits their metastatic lung colonization in Balb/c-mice.

Authors:  G Pulverer; J Beuth; H L Ko; A Yassin; Y Ohshima; K Roszkowski; G Uhlenbruck
Journal:  J Cancer Res Clin Oncol       Date:  1988       Impact factor: 4.553

Review 2.  Importance of lectins for the prevention of bacterial infections and cancer metastases.

Authors:  J Beuth; H L Ko; G Pulverer; G Uhlenbruck; H Pichlmaier
Journal:  Glycoconj J       Date:  1995-02       Impact factor: 2.916

3.  Blocking of lectin-like adhesion molecules on pulmonary cells inhibits lung sarcoma L-1 colonization in BALB/c-mice.

Authors:  W Roszkowski; J Beuth; H L Ko; G Uhlenbruck; G Pulverer
Journal:  Experientia       Date:  1989-06-15

4.  New, simple model of mesenteric lymph node metastases in the rat.

Authors:  J D Nagel; W J Mooi; J G McVie
Journal:  Clin Exp Metastasis       Date:  1989 Jul-Aug       Impact factor: 5.150

5.  Proprietary arabinogalactan extract increases antibody response to the pneumonia vaccine: a randomized, double-blind, placebo-controlled, pilot study in healthy volunteers.

Authors:  Jay K Udani; Betsy B Singh; Marilyn L Barrett; Vijay J Singh
Journal:  Nutr J       Date:  2010-08-26       Impact factor: 3.271

6.  Hepatocellular injury inhibits lectin-mediated tumor colonization into BALB/c-mice livers.

Authors:  J Beuth; H L Ko; M Steuer; G Pulverer
Journal:  Experientia       Date:  1993-07-05

7.  What makes cancer stem cell markers different?

Authors:  Uwe Karsten; Steffen Goletz
Journal:  Springerplus       Date:  2013-07-04
  7 in total

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