Literature DB >> 3345349

Rearrangement and expression of T-cell receptor genes in large granular lymphocyte leukemia.

T P Loughran1, G Starkebaum, J A Aprile.   

Abstract

Ten patients with large granular lymphocyte (LGL) leukemia were studied for rearrangement and expression of T cell receptor (TCR) genes. Eight patients with CD3+ LGL proliferation had unique TCR beta-gene rearrangements, supporting a clonal process. Each of five patients studied with CD3+ disease had evidence for expression of full-length TCR alpha-, beta-, and gamma-gene transcripts. In contrast, patients with CD3- LGL proliferation had no evidence for rearrangement or expression of TCR genes. These studies suggest that leukemic LGL arise from two different cell origins. Leukemic LGL may be a useful model for studying natural killer (NK) cell (CD3- LGL) and non-MHC-restricted cytotoxic T lymphocyte (CD3+ LGL) activation and differentiation.

Entities:  

Mesh：

Substances：

Year:  1988        PMID： 3345349

Source DB:  PubMed          Journal:  Blood        ISSN： 0006-4971            Impact factor:   22.113


  9 in total

1.  BIOMED-2 multiplex immunoglobulin/T-cell receptor polymerase chain reaction protocols can reliably replace Southern blot analysis in routine clonality diagnostics.

Authors:  Yorick Sandberg; Ellen J van Gastel-Mol; Brenda Verhaaf; King H Lam; Jacques J M van Dongen; Anton W Langerak
Journal:  J Mol Diagn       Date:  2005-10       Impact factor: 5.568

2.  Granular lymphocyte proliferative disorders: a multicenter study of 20 cases.

Authors:  S Woessner; E Feliu; N Villamor; M A Zarco; A Domingo; F Millá; L Florensa; M Rozman; E Abella; J Soler
Journal:  Ann Hematol       Date:  1994-06       Impact factor: 3.673

3.  MICA polymorphism identified by whole genome array associated with NKG2D-mediated cytotoxicity in T-cell large granular lymphocyte leukemia.

Authors:  Aaron D Viny; Michael J Clemente; Monika Jasek; Medhat Askar; Hemant Ishwaran; Amy Nowacki; Aiwen Zhang; Jaroslaw P Maciejewski
Journal:  Haematologica       Date:  2010-05-11       Impact factor: 9.941

4.  Clonal predominance of CD8(+) T cells in patients with unexplained neutropenia.

Authors:  Marcin Wojciech Wlodarski; Zachary Nearman; Ying Jiang; Alan Lichtin; Jaroslaw Pawel Maciejewski
Journal:  Exp Hematol       Date:  2008-03       Impact factor: 3.084

5.  Clonality of CD3 negative large granular lymphocyte proliferations determined by PCR based X-inactivation studies.

Authors:  A Kelly; S J Richards; M Sivakumaran; C Shiach; A D Stewart; B E Roberts; C S Scott
Journal:  J Clin Pathol       Date:  1994-05       Impact factor: 3.411

6.  Therapeutic implications of variable expression of CD52 on clonal cytotoxic T cells in CD8+ large granular lymphocyte leukemia.

Authors:  Sanjay R Mohan; Michael J Clemente; Manuel Afable; Heather N Cazzolli; Nelli Bejanyan; Marcin W Wlodarski; Alan E Lichtin; Jaroslaw P Maciejewski
Journal:  Haematologica       Date:  2009-10       Impact factor: 9.941

7.  Phenotypic differences between healthy effector CTL and leukemic LGL cells support the notion of antigen-triggered clonal transformation in T-LGL leukemia.

Authors:  Marcin W Wlodarski; Zachary Nearman; Anna Jankowska; Nina Babel; Jennifer Powers; Patrick Leahy; Hans-Dieter Volk; Jaroslaw P Maciejewski
Journal:  J Leukoc Biol       Date:  2007-12-17       Impact factor: 4.962

8.  A quantitative real time PCR method to analyze T cell receptor Vbeta subgroup expansion by staphylococcal superantigens.

Authors:  Keun Seok Seo; Joo Youn Park; David S Terman; Gregory A Bohach
Journal:  J Transl Med       Date:  2010-01-13       Impact factor: 5.531

9.  Oral manifestations of T-cell large granular lymphocytic leukemia: a case report.

Authors:  Ioanna-Eirini Arvanitidou; Nikolaos G Nikitakis; Alexandra Sklavounou
Journal:  J Oral Maxillofac Res       Date:  2011-10-01
  9 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.