| Literature DB >> 33453364 |
Gisele Nishiguchi1, Sourav Das1, Jason Ochoada1, Heather Long1, Richard E Lee1, Zoran Rankovic1, Anang A Shelat2.
Abstract
The quality of lead compounds is a key factor for determining the success of chemical probe and drug discovery programs. Given that high-throughput screening (HTS) continues to be a dominant lead generation paradigm, access to high-quality screening libraries is crucial for such efforts in both industry and academia. Here, we discuss the strategy implemented a decade ago to build from scratch one of the largest compound collections in academia, containing ∼575 000 carefully annotated small molecules, and a recent multidisciplinary effort designed to further enhance the collection to meet our research demands for the next decade.Entities:
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Year: 2021 PMID： 33453364 PMCID： PMC8131249 DOI： 10.1016/j.drudis.2021.01.005
Source DB: PubMed Journal: Drug Discov Today ISSN： 1359-6446 Impact factor: 7.851