| Literature DB >> 33452423 |
Jiahao Zhang1,2,3,4, Kaixiong Ma1,2, Bo Li1,2, Yiqun Chen1,2, Ziwen Qiu1,2, Jinchao Xing1,3, Jinyu Huang1,2, Chen Hu1,3, Yifan Huang1,3, Huanan Li1,2, Dingxiang Liu5, Ming Liao6,7,8,9,10,11,12, Wenbao Qi13,14,15,16,17,18,19.
Abstract
Low pathogenic avian influenza A(H9N2) virus is endemic worldwide and continually recruit internal genes to generate human-infecting H5N1, H5N6, H7N9, and H10N8 influenza variants. Here we show that hemagglutinin cleavage sites (HACS) of H9N2 viruses tended to mutate towards hydrophilic via evolutionary transition, and the tribasic HACS were found at high prevalence in Asia and the Middle East. Our finding suggested that the tribasic H9N2 viruses increased the viral replication, stability, pathogenicity and transmission in chickens and the virulence of mice compared to the monobasic H9N2 viruses. Notably, the enlarged stem-loop structures of HACS in the RNA region were found in the increasing tribasic H9N2 viruses. The enlarged HACS RNA secondary structures of H9N2 viruses did not influence the viral replication but accelerated the frequency of nucleotide insertion in HACS. With the prevailing tendency of the tribasic H9N2 viruses, the tribasic HACS in H9N2 viruses should be paid more attention.Entities:
Mesh：
Substances：
Year: 2021 PMID： 33452423 PMCID： PMC7811019 DOI： 10.1038/s42003-020-01589-7
Source DB: PubMed Journal: Commun Biol ISSN： 2399-3642