| Literature DB >> 27916476 |
Yuhai Bi1, Quanjiao Chen2, Qianli Wang3, Jianjun Chen2, Tao Jin4, Gary Wong5, Chuansong Quan6, Jun Liu6, Jun Wu3, Renfu Yin7, Lihua Zhao2, Mingxin Li2, Zhuang Ding7, Rongrong Zou8, Wen Xu9, Hong Li9, Huijun Wang10, Kegong Tian11, Guanghua Fu12, Yu Huang12, Alexander Shestopalov13, Shoujun Li14, Bing Xu15, Hongjie Yu16, Tingrong Luo17, Lin Lu9, Xun Xu4, Yang Luo18, Yingxia Liu19, Weifeng Shi20, Di Liu21, George Fu Gao22.
Abstract
Constant surveillance of live poultry markets (LPMs) is currently the best way to predict and identify emerging avian influenza viruses (AIVs) that pose a potential threat to public health. Through surveillance of LPMs from 16 provinces and municipalities in China during 2014-2016, we identified 3,174 AIV-positive samples and isolated and sequenced 1,135 AIVs covering 31 subtypes. Our analysis shows that H5N6 has replaced H5N1 as one of the dominant AIV subtypes in southern China, especially in ducks. Phylogenetic analysis reveals that H5N6 arose from reassortments of H5 and H6N6 viruses, with the hemagglutinin and neuraminidase combinations being strongly lineage specific. H5N6 viruses constitute at least 34 distinct genotypes derived from various evolutionary pathways. Notably, genotype G1.2 virus, with internal genes from the chicken H9N2/H7N9 gene pool, was responsible for at least five human H5N6 infections. Our findings highlight H5N6 AIVs as potential threats to public health and agriculture.Entities:
Keywords: H5N6 avian influenza; birds; evolution; genesis; human infection; live poultry markets; prevalence; resassortment
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Year: 2016 PMID： 27916476 DOI： 10.1016/j.chom.2016.10.022
Source DB: PubMed Journal: Cell Host Microbe ISSN： 1931-3128 Impact factor: 21.023