Literature DB >> 3345107

Low free testosterone levels in rheumatoid arthritis.

T D Spector1, L A Perry, G Tubb, A J Silman, E C Huskisson.   

Abstract

The androgen status of 25 male patients with rheumatoid arthritis (RA) was assessed and compared with that of age matched controls with osteoarthritis (OA). Significantly reduced levels of serum free testosterone were found in the RA group. Within that group free testosterone was unrelated to all indices of disease activity measured, though it was strongly related to latex positivity. These results support the hypothesis that male sex hormones may have a protective role in RA, though prospective studies would be necessary to determine whether the relation was one of cause or effect.

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Year:  1988        PMID： 3345107      PMCID： PMC1003446          DOI： 10.1136/ard.47.1.65

Source DB:  PubMed          Journal:  Ann Rheum Dis        ISSN： 0003-4967            Impact factor:   19.103


  10 in total

1.  Androgenic status and sexual function in males with rheumatoid arthritis and ankylosing spondylitis.

Authors:  D Gordon; G H Beastall; J A Thomson; R D Sturrock
Journal:  Q J Med       Date:  1986-07

Review 2.  The pituitary-adrenocortical axis and the immune system.

Authors:  J E Blalock; E M Smith; W J Meyer
Journal:  Clin Endocrinol Metab       Date:  1985-11

3.  Sex steroids and the rheumatic diseases.

Authors:  R G Lahita
Journal:  Arthritis Rheum       Date:  1985-02

4.  Hormonal changes and sexual function in aging men.

Authors:  J M Davidson; J J Chen; L Crapo; G D Gray; W J Greenleaf; J A Catania
Journal:  J Clin Endocrinol Metab       Date:  1983-07       Impact factor: 5.958

5.  Immunologic sex differences and the female predominance in systemic lupus erythematosus.

Authors:  R D Inman
Journal:  Arthritis Rheum       Date:  1978 Sep-Oct

6.  Androgen plasma levels in female rheumatoid arthritis patients.

Authors:  M Dougados; K Nahoul; L Benhamou; B Amor
Journal:  Arthritis Rheum       Date:  1983-07

7.  The epidemiology of rheumatoid arthritis in Rochester, Minnesota: a study of incidence, prevalence, and mortality.

Authors:  A Linos; J W Worthington; W M O'Fallon; L T Kurland
Journal:  Am J Epidemiol       Date:  1980-01       Impact factor: 4.897

8.  Sex hormone status in women suffering from rheumatoid arthritis.

Authors:  M Cutolo; E Balleari; M Giusti; M Monachesi; S Accardo
Journal:  J Rheumatol       Date:  1986-12       Impact factor: 4.666

Review 9.  Low adrenal androgenic-anabolic steroids in women with rheumatoid arthritis (RA): gas-liquid chromatographic studies of RA patients and matched normal control women indicating decreased 11-deoxy-17-ketosteroid excretion.

Authors:  A T Masi; D B Josipović; W E Jefferson
Journal:  Semin Arthritis Rheum       Date:  1984-08       Impact factor: 5.532

10.  Plasma dehydroepiandrosterone, dehydroepiandrosterone sulphate and androsterone sulphate levels and their interaction with plasma proteins in rheumatoid arthritis.

Authors:  K G Fehér; T Fehér
Journal:  Exp Clin Endocrinol       Date:  1984-10
  10 in total
  18 in total

Review 1.  Hypophyseal-pituitary-adrenal axis in autoimmune and rheumatic diseases.

Authors:  B H Athreya; P Rettig; W V Williams
Journal:  Immunol Res       Date:  1998       Impact factor: 2.829

2.  A study of serum androgen and cortisol levels in female patients with rheumatoid arthritis. Correlation with disease activity.

Authors:  L Mirone; L Altomonte; P D'Agostino; A Zoli; A Barini; M Magaro
Journal:  Clin Rheumatol       Date:  1996-01       Impact factor: 2.980

3.  Free and serum testosterone levels in 276 males: a comparative study of rheumatoid arthritis, ankylosing spondylitis and healthy controls.

Authors:  T D Spector; W Ollier; L A Perry; A J Silman; P W Thompson; A Edwards
Journal:  Clin Rheumatol       Date:  1989-03       Impact factor: 2.980

4.  Why the gender difference in susceptibility to rheumatoid arthritis?

Authors:  P Brennan; A Silman
Journal:  Ann Rheum Dis       Date:  1995-09       Impact factor: 19.103

Review 5.  Sex hormones, glucocorticoids and autoimmunity: facts and hypotheses.

Authors:  J A Da Silva
Journal:  Ann Rheum Dis       Date:  1995-01       Impact factor: 19.103

6.  Rheumatoid arthritis, the contraceptive pill, and androgens.

Authors:  W H James
Journal:  Ann Rheum Dis       Date:  1993-06       Impact factor: 19.103

7.  Effects of androgens in models of rheumatoid arthritis.

Authors:  A Steward; D L Bayley
Journal:  Agents Actions       Date:  1992-03

8.  Serum androgen-anabolic hormones and the risk of rheumatoid arthritis.

Authors:  R Heikkilä; K Aho; M Heliövaara; P Knekt; A Reunanen; A Aromaa; A Leino; T Palosuo
Journal:  Ann Rheum Dis       Date:  1998-05       Impact factor: 19.103

Review 9.  Why are women predisposed to autoimmune rheumatic diseases?

Authors:  Jacqueline E Oliver; Alan J Silman
Journal:  Arthritis Res Ther       Date:  2009-10-26       Impact factor: 5.156

10.  A prospective study of androgen levels, hormone-related genes and risk of rheumatoid arthritis.

Authors:  Elizabeth W Karlson; Lori B Chibnik; Monica McGrath; Shun-Chiao Chang; Brendan T Keenan; Karen H Costenbader; Patricia A Fraser; Shelley Tworoger; Susan E Hankinson; I-Min Lee; Julie Buring; Immaculata De Vivo
Journal:  Arthritis Res Ther       Date:  2009-06-25       Impact factor: 5.156
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