Aamna Bibi1, Sheng-Chieh Hsu1, Wei-Fu Ji1, Yi-Chi Cho1, Karen S Santiago2, Jui-Ming Yeh1. 1. Department of Chemistry and Center for Nanotechnology, Chung Yuan Christian University, Chung Li District, Tao-Yuan City 32023, Taiwan. 2. Department of Chemistry, College of Science, University of Santo Tomas, España, Manila 1015, Philippines.
Abstract
In this present work, an electrochemical sensor was developed for the sensing of uric acid (UA). The sensor was based on a carbon paste electrode (CPE) modified with electroactive polyimide (EPI) synthesized using aniline tetramer (ACAT) decorated with reduced nanoparticles (NPs) of Au, Pt, and Ag. The initial step involved the preparation and characterization of ACAT. Subsequently, the ACAT-based EPI synthesis was performed by chemical imidization of its precursors 4,4'-(4.4'-isopropylidene-diphenoxy) bis (phthalic anhydride) BPADA and ACAT. Then, EPI was doped with distinctive particles of Ag, Pt and Au, and the doped EPIs were abbreviated as EPIS, EPIP and EPIG, respectively. Their structures were characterized by XRD, XPS, and TEM, and the electrochemical properties were determined by cyclic voltammetry and chronoamperometry. Among these evaluated sensors, EPI with Au NPs turned out the best with a sensitivity of 1.53 uA uM-1 UA, a low limit of detection (LOD) of 0.78 uM, and a linear detection range (LDR) of 5-50 uM UA at a low potential value of 310 mV. Additionally, differential pulse voltammetric (DPV) analysis showed that the EPIG sensor showed the best selectivity for a tertiary mixture of UA, dopamine (DA), and ascorbic acid (AA) as compared to EPIP and EPIS.
In this present work, an electrochemical sensor was developed for the sensing of uric acid (n class="Chemical">UA). The sensor was based on a carbon paste electrode (CPE) modified with electroactive polyimide (EPI) synthesized using aniline tetramer (ACAT) decorated with reduced nanoparticles (NPs) of Au, Pt, and Ag. The initial step involved the preparation and characterization of ACAT. Subsequently, the ACAT-based EPI synthesis was performed by chemical imidization of its precursors 4,4'-(4.4'-isopropylidene-diphenoxy) bis (phthalic anhydride) BPADA and ACAT. Then, EPI was doped with distinctive particles of Ag, Pt and Au, and the doped EPIs were abbreviated as EPIS, EPIP and EPIG, respectively. Their structures were characterized by XRD, XPS, and TEM, and the electrochemical properties were determined by cyclic voltammetry and chronoamperometry. Among these evaluated sensors, EPI with Au NPs turned out the best with a sensitivity of 1.53 uA uM-1 UA, a low limit of detection (LOD) of 0.78 uM, and a linear detection range (LDR) of 5-50 uM UA at a low potential value of 310 mV. Additionally, differential pulse voltammetric (DPV) analysis showed that the EPIG sensor showed the best selectivity for a tertiary mixture of UA, dopamine (DA), and ascorbic acid (AA) as compared to EPIP and EPIS.
Authors: John G Hardy; David J Mouser; Netzahualcóyotl Arroyo-Currás; Sydney Geissler; Jacqueline K Chow; Lindsey Nguy; Jong M Kim; Christine E Schmidt Journal: J Mater Chem B Date: 2014-09-04 Impact factor: 6.331