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Literature DB >> 33450206

Telomeres: history, health, and hallmarks of aging.

Deepavali Chakravarti¹, Kyle A LaBella¹, Ronald A DePinho².

Abstract

The escalating social and economic burden of an aging world population has placed aging research at center stage. The hallmarks of aging comprise diverse molecular mechanisms and cellular systems that are interrelated and act in concert to drive the aging process. Here, through the lens of telomere biology, we examine how telomere dysfunction may amplify or drive molecular biological processes underlying each hallmark of aging and contribute to development of age-related diseases such as neurodegeneration and cancer. The intimate link of telomeres to aging hallmarks informs preventive and therapeutic interventions designed to attenuate aging itself and reduce the incidence of age-associated diseases.

Entities: Chemical

Mesh：

Substances：
Telomerase

Year: 2021 PMID： 33450206 PMCID： PMC8081271 DOI： 10.1016/j.cell.2020.12.028

Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 41.582

148 in total

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Authors: Andrea Sottoriva; Haeyoun Kang; Zhicheng Ma; Trevor A Graham; Matthew P Salomon; Junsong Zhao; Paul Marjoram; Kimberly Siegmund; Michael F Press; Darryl Shibata; Christina Curtis
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Authors: JinWoo Hong; Chae-Ok Yun
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46 in total

1. Single-cell transcriptomics identifies premature aging features of TERC-deficient mouse brain and bone marrow.

Authors: Chunying Yang; Yidan Pang; Yigang Huang; Fang Ye; Xiaoyi Chen; Youshui Gao; Changqing Zhang; Lufeng Yao; Junjie Gao
Journal: Geroscience Date: 2022-05-11 Impact factor: 7.713

2. Senomorphic agent pterostilbene ameliorates osteoarthritis through the PI3K/AKT/NF-κB axis: an in vitro and in vivo study.

Authors: Yu Wang; Huai Zhao; Shuangshuo Jia; Qian Wang; Wuyi Yao; Yue Yang; Lunhao Bai
Journal: Am J Transl Res Date: 2022-08-15 Impact factor: 3.940

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Authors: Qing Yin; Ya-Jie Zhao; Wei-Jie Ni; Tao-Tao Tang; Yao Wang; Jing-Yuan Cao; Di Yin; Yi Wen; Zuo-Lin Li; Yi-Lin Zhang; Wei Jiang; Yue Zhang; Xiao-Yu Lu; Ai-Qing Zhang; Wei-Hua Gan; Lin-Li Lv; Bi-Cheng Liu; Bin Wang
Journal: Theranostics Date: 2022-06-06 Impact factor: 11.600