Mina Kiafar1,2, Seyedeh Tahereh Faezi3, Amir Kasaeian4, Azarakhsh Baghdadi5, Sahar Kakaei6, Seyed Ali Mousavi1, Mohammad Nejadhosseinian1, Farhad Shahram1, Seyedeh Zahra Ghodsi7, Hormoz Shams1, Fereydoun Davatchi1. 1. Rheumatology Research Center, Tehran University of Medical Sciences, North Amirabad Street, Tehran, 1411713137, Iran. 2. Valiasr Education and Treatment Center, Zanjan University of Medical Science, Zanjan, Iran. 3. Rheumatology Research Center, Tehran University of Medical Sciences, North Amirabad Street, Tehran, 1411713137, Iran. tfaezi@sina.tums.ac.ir. 4. Hematology-Oncology and Stem Cell Transplantation Research Center, Tehran University of Medical Sciences, Tehran, Iran. 5. Rheumatology Research Center, Tehran University of Medical Sciences, North Amirabad Street, Tehran, 1411713137, Iran. azarakhsh.baghdadi88@gmail.com. 6. Internal Medicine Center, Zahedan University of Medical Sciences, Zahedan, Iran. 7. Department of Dermatology, Razi Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Abstract
BACKGROUND: The diagnosis of Behçet disease (BD) is challenging in many cases. The purpose of this study was to describe the clinical characteristics of patients at a referral BD clinic. METHODS: In a retrospective study, we collected data from patients at a national referral Behçet clinic from November 2018-August 2019. A BD diagnosis was confirmed (BD group) or ruled out (Non-BD group), and the two groups were compared for differences. RESULTS: A total of 238 patients satisfied the inclusion criteria. Forty patients (16.8%) were finally diagnosed with BD. Ocular and genital lesions were significantly more prevalent in the BD group. A positive pathergy test and HLA-B51 were also significantly more common in BD. However, oral lesions, articular involvement, and gastrointestinal manifestations were similar between groups. Also, patients with BD were significantly more likely to have multi-organ (≥2 organ systems) involvement. CONCLUSIONS: Being the first study to evaluate the clinical characteristics of patients who are visited at a referral BD clinic and are believed to have a high probability of Behçet, the results of this study are important from an epidemiological standpoint. Also, the findings of this study could be used by referral Behçet clinics, which evaluate and diagnose patients with a high pretest probability and atypical presentations of BD on a daily basis. The alternative diagnoses established in this study could be used as the list of the most common differential diagnoses for Behçet's disease.
BACKGROUND: The diagnosis of Behçet disease (BD) is challenging in many cases. The purpose of this study was to describe the clinical characteristics of patients at a referral BD clinic. METHODS: In a retrospective study, we collected data from patients at a national referral Behçet clinic from November 2018-August 2019. A BD diagnosis was confirmed (BD group) or ruled out (Non-BD group), and the two groups were compared for differences. RESULTS: A total of 238 patients satisfied the inclusion criteria. Forty patients (16.8%) were finally diagnosed with BD. Ocular and genital lesions were significantly more prevalent in the BD group. A positive pathergy test and HLA-B51 were also significantly more common in BD. However, oral lesions, articular involvement, and gastrointestinal manifestations were similar between groups. Also, patients with BD were significantly more likely to have multi-organ (≥2 organ systems) involvement. CONCLUSIONS: Being the first study to evaluate the clinical characteristics of patients who are visited at a referral BD clinic and are believed to have a high probability of Behçet, the results of this study are important from an epidemiological standpoint. Also, the findings of this study could be used by referral Behçet clinics, which evaluate and diagnose patients with a high pretest probability and atypical presentations of BD on a daily basis. The alternative diagnoses established in this study could be used as the list of the most common differential diagnoses for Behçet's disease.
Authors: Antonio Greco; Armando De Virgilio; Massimo Ralli; Andrea Ciofalo; Patrizia Mancini; Giuseppe Attanasio; Marco de Vincentiis; Alessandro Lambiase Journal: Autoimmun Rev Date: 2018-04-06 Impact factor: 9.754
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Authors: Shereen H Aboul Naga; Lameece Moustafa Hassan; Radwa T El Zanaty; Mohammad Refaat; Rana H Amin; Gaafar Ragab; Mahmoud M Soliman Journal: Front Med (Lausanne) Date: 2022-09-07