Anthony Nguyen1, Shubhra Upadhyay1, Muhammad Ali Javaid2, Abdul Moiz Qureshi3, Shahan Haseeb3, Nismat Javed3, Christopher Cormier4, Asif Farooq5, Abu Baker Sheikh1. 1. Department of Internal Medicine, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, USA. 2. Department of Internal Medicine, Dow Medical College, Karachi, Pakistan. 3. Department of Internal Medicine, Shifa College of Medicine, Shifa Tameer-e-Millat University, Islamabad, Pakistan. 4. Department of Pathology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, USA. 5. Department of Family and Community Medicine, Texas Tech Health Sciences Center, Lubbock, Texas, USA.
Abstract
BACKGROUND: Behcet's disease (BD) is a complex inflammatory vascular disorder that follows a relapsing-remitting course with diverse clinical manifestations. The prevalence of the disease varies throughout the globe and targets different age-groups. There are many variations of BD; however, intestinal BD is not only more common but has many signs and symptoms. SUMMARY: BD is a relapsing-remitting inflammatory vascular disorder with multiple system involvement, affecting vessels of all types and sizes that targets young adults. The etiology of BD is unknown but many factors including genetic mechanisms, vascular changes, hypercoagulability, and dysregulation of immune function are believed to be responsible. BD usually presents with signs and symptoms of ulcerative disease of the small intestine; endoscopy being consistent with the clinical manifestations. The mainstay of treatment depends upon the severity of the disease. Corticosteroids are recommended for severe forms of the disease and aminosalicylic acids are used in maintaining remission in mild to moderate forms of the disease. KEY MESSAGES: In this review, we have tried to summarize in the present review the clinical manifestations, differential diagnoses, and management of intestinal BD. Hopefully, this review will enable health policymakers to ponder over establishing clear endpoints for treatment, surveillance investigations, and creating robust algorithms.
BACKGROUND: Behcet's disease (BD) is a complex inflammatory vascular disorder that follows a relapsing-remitting course with diverse clinical manifestations. The prevalence of the disease varies throughout the globe and targets different age-groups. There are many variations of BD; however, intestinal BD is not only more common but has many signs and symptoms. SUMMARY: BD is a relapsing-remitting inflammatory vascular disorder with multiple system involvement, affecting vessels of all types and sizes that targets young adults. The etiology of BD is unknown but many factors including genetic mechanisms, vascular changes, hypercoagulability, and dysregulation of immune function are believed to be responsible. BD usually presents with signs and symptoms of ulcerative disease of the small intestine; endoscopy being consistent with the clinical manifestations. The mainstay of treatment depends upon the severity of the disease. Corticosteroids are recommended for severe forms of the disease and aminosalicylic acids are used in maintaining remission in mild to moderate forms of the disease. KEY MESSAGES: In this review, we have tried to summarize in the present review the clinical manifestations, differential diagnoses, and management of intestinal BD. Hopefully, this review will enable health policymakers to ponder over establishing clear endpoints for treatment, surveillance investigations, and creating robust algorithms.
Authors: Jae Hee Cheon; Dong Soo Han; Jeong Youp Park; Byong Duk Ye; Sung Ae Jung; Young Sook Park; You Sun Kim; Joo Sung Kim; Chung Mo Nam; Youn Nam Kim; Suk-Kyun Yang; Won Ho Kim Journal: Inflamm Bowel Dis Date: 2011-02 Impact factor: 5.325
Authors: H Direskeneli; G Keser; D D'Cruz; M A Khamashta; T Akoğlu; H Yazici; S Yurdakul; V Hamuryudan; S Ozgün; A J Goral Journal: Clin Rheumatol Date: 1995-01 Impact factor: 2.980