Daisuke Sueta1, Hiroki Usuku1,2, Yui Kinoshita2, Kenichi Tsujita1. 1. Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, 1-1-1, Honjo, Chuo-ku, Kumamoto 860-8556, Japan. 2. Department of Molecular Laboratory, Graduate School of Medical Sciences, Kumamoto University, 1-1-1, Honjo, Chuo-ku, Kumamoto 860-8556, Japan.
Abstract
BACKGROUND: The onset prevention and early diagnosis in cardiotoxicity due to cancer chemotherapy are important, and it is important to detect cardiac dysfunction at an early stage and start treatment to enhance the therapeutic effect. CASE SUMMARY: A 31-year-old female with breast cancer received chemotherapy with epirubicin (400 mg/m2) and cyclophosphamide followed by docetaxel. Two months after the initiation of her chemotherapy, the left ventricular (LV) ejection fraction (LVEF) determined by echocardiography fell to 41.2%, and she was diagnosed with cancer therapy-related cardiac dysfunction (CTRCD). Three months after the initiation of cancer treatment, the peak velocity of late diastolic transmitral Doppler flow (A wave) became undetectable. Peak longitudinal strain (LS) and peak LS rate, which reflect left atrium (LA) reservoir function, gradually declined like the LVEF and LV-global LS (GLS). Seven months after the initiation of cancer treatment, she was diagnosed with acute decompensated heart failure. The changes in peak LS and peak LS at the onset were greater than those in LVEF and LV-GLS. DISCUSSION: This is a case report suggesting that LA reservoir function might be a more sensitive indicator than LVEF or LV-GLS in detecting CTRCD and that LA booster function might be the earliest. Left atrium reservoir function might be a more sensitive than conventional LV pump function and optimal indicator in CTRCD.
BACKGROUND: The onset prevention and early diagnosis in cardiotoxicity due to cancer chemotherapy are important, and it is important to detect cardiac dysfunction at an early stage and start treatment to enhance the therapeutic effect. CASE SUMMARY: A 31-year-old female with breast cancer received chemotherapy with epirubicin (400 mg/m2) and cyclophosphamide followed by docetaxel. Two months after the initiation of her chemotherapy, the left ventricular (LV) ejection fraction (LVEF) determined by echocardiography fell to 41.2%, and she was diagnosed with cancer therapy-related cardiac dysfunction (CTRCD). Three months after the initiation of cancer treatment, the peak velocity of late diastolic transmitral Doppler flow (A wave) became undetectable. Peak longitudinal strain (LS) and peak LS rate, which reflect left atrium (LA) reservoir function, gradually declined like the LVEF and LV-global LS (GLS). Seven months after the initiation of cancer treatment, she was diagnosed with acute decompensated heart failure. The changes in peak LS and peak LS at the onset were greater than those in LVEF and LV-GLS. DISCUSSION: This is a case report suggesting that LA reservoir function might be a more sensitive indicator than LVEF or LV-GLS in detecting CTRCD and that LA booster function might be the earliest. Left atrium reservoir function might be a more sensitive than conventional LV pump function and optimal indicator in CTRCD.
Authors: E Galli; M Fournet; C Chabanne; B Lelong; A Leguerrier; E Flecher; P Mabo; E Donal Journal: Eur Heart J Cardiovasc Imaging Date: 2015-09-20 Impact factor: 6.875
Authors: Teresa López-Fernández; Ana Martín García; Ana Santaballa Beltrán; Ángel Montero Luis; Ramón García Sanz; Pilar Mazón Ramos; Sonia Velasco Del Castillo; Esteban López de Sá Areses; Manuel Barreiro-Pérez; Rocío Hinojar Baydes; Leopoldo Pérez de Isla; Silvia Cayetana Valbuena López; Regina Dalmau González-Gallarza; Francisco Calvo-Iglesias; Juan José González Ferrer; Antonio Castro Fernández; Eva González-Caballero; Cristina Mitroi; Meritxell Arenas; Juan Antonio Virizuela Echaburu; Pascual Marco Vera; Andrés Íñiguez Romo; José Luis Zamorano; Juan Carlos Plana Gómez; José Luis López Sendón Henchel Journal: Rev Esp Cardiol (Engl Ed) Date: 2017-03-18
Authors: Benjamin H Freed; Vistasp Daruwalla; Jeanette Y Cheng; Frank G Aguilar; Lauren Beussink; Andrew Choi; David A Klein; Debra Dixon; Abigail Baldridge; Laura J Rasmussen-Torvik; Kameswari Maganti; Sanjiv J Shah Journal: Circ Cardiovasc Imaging Date: 2016-03 Impact factor: 7.792