Literature DB >> 33442068

Stereospecific Cross-Coupling Reactions Provide Conformationally-Biased Arylalkanes with Anti-Leukemia Activity.

Amberly B Sanford1, Emily J Tollefson1, Elizabeth R Jarvo1.   

Abstract

A focused small library of carbamates and alcohols was prepared employing stereospecific Kumada-ring opening reactions of tetrahydropyrans. The core framework of the library members is acyclic and incorporates 1,3-substituents, to provide a conformational bias in avoiding syn-pentane interactions. A new compound with micromolar activity against MOLT-4, CCRF-CEM, and HL-60(TB) leukemia cell lines was identified from this series.

Entities:  

Keywords:  C–O coupling; Leukemia; Nickel; cross-coupling; syn-pentane

Year:  2019        PMID： 33442068      PMCID： PMC7799436          DOI： 10.1002/ijch.201900071

Source DB:  PubMed          Journal:  Isr J Chem        ISSN： 0021-2148            Impact factor:   3.333


  19 in total

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10.  Stereospecific cross-coupling reactions of aryl-substituted tetrahydrofurans, tetrahydropyrans, and lactones.

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  2 in total

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2.  Harnessing C-O Bonds in Stereoselective Cross-Coupling and Cross-Electrophile Coupling Reactions.

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