Literature DB >> 11259039

Solution structure of (+)-discodermolide.

A B Smith1, M J LaMarche, M Falcone-Hindley.   

Abstract

[structure: see text]. The solution structure of (+)-discodermolide (1) has been determined via 1- and 2-D NMR techniques in conjunction with Monte Carlo conformational analysis. Taken together, the results demonstrate that in solution (+)-discodermolide occupies a helical conformation remarkably similar to the solid state conformation.

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Year:  2001        PMID： 11259039     DOI： 10.1021/ol006967p

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  10 in total

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Review 3.  Microtubule stabilizing agents as potential treatment for Alzheimer's disease and related neurodegenerative tauopathies.

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5.  Total synthesis and biological evaluation of a series of macrocyclic hybrids and analogues of the antimitotic natural products dictyostatin, discodermolide, and taxol.

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6.  Design and synthesis of (+)-discodermolide-paclitaxel hybrids leading to enhanced biological activity.

Authors:  Amos B Smith; Keizo Sugasawa; Onur Atasoylu; Chia-Ping Huang Yang; Susan Band Horwitz
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7.  Structural Basis of Microtubule Stabilization by Discodermolide.

Authors:  Andrea E Prota; Katja Bargsten; Mariano Redondo-Horcajo; Amos B Smith; Chia-Ping H Yang; Hayley M McDaid; Ian Paterson; Susan B Horwitz; José Fernando Díaz; Michel O Steinmetz
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8.  Human liver microsomal metabolism of (+)-discodermolide.

Authors:  Yun Fan; Emanuel M Schreiber; Billy W Day
Journal:  J Nat Prod       Date:  2009-10       Impact factor: 4.050

9.  Structural Determinants of the Dictyostatin Chemotype for Tubulin Binding Affinity and Antitumor Activity Against Taxane- and Epothilone-Resistant Cancer Cells.

Authors:  Chiara Trigili; Isabel Barasoain; Pedro A Sánchez-Murcia; Katja Bargsten; Mariano Redondo-Horcajo; Aurora Nogales; Nicola M Gardner; Arndt Meyer; Guy J Naylor; Elena Gómez-Rubio; Federico Gago; Michel O Steinmetz; Ian Paterson; Andrea E Prota; J Fernando Díaz
Journal:  ACS Omega       Date:  2016-12-13

Review 10.  Natural Polypropionates in 1999-2020: An Overview of Chemical and Biological Diversity.

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  10 in total

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