Literature DB >> 33437870

Transformation of monoclonal B lymphocytosis to Epstein-Barr virus-positive large B-cell lymphoma with intermediate features between diffuse large B-cell lymphoma and classic Hodgkin lymphoma.

Ying Liu1, Caleb Ho1, Mikhail Roshal1, Jeeyeon Baik1, Maria Arcila1, Yanming Zhang1, Ahmet Dogan1, Wenbin Xiao1.   

Abstract

Transformation of chronic lymphocytic leukemia (CLL) to an aggressive lymphoma, so-called Richter syndrome (RS), usually includes diffuse large B-cell lymphoma (DLBCL) and classic Hodgkin lymphoma (CHL). The transformation can be clonally related to the underlying CLL, and is often Epstein-Barr virus (EBV)-associated. Here we report an 86-year-old female with a newly identified CLL-like monoclonal B-lymphocytosis (MBL) who developed diffuse lymphadenopathy. Biopsy of the left axillary lymph node showed EBV-positive large B-cell lymphoma with morphologic and immunophenotypic features intermediate between DLBCL and CHL, so-called gray zone lymphoma. Comprehensive immunophenotypic, cytogenetics and molecular studies demonstrate a clonal relatedness that suggests a transformation from MBL to EBV+ gray zone lymphoma.

Entities:  

Keywords:  Chronic lymphocytic leukemia; EBV+ diffuse large B-cell lymphoma; Richter syndrome/transformation; classic Hodgkin lymphoma; gray zone lymphoma; monoclonal B-lymphocytosis

Year:  2019        PMID： 33437870      PMCID： PMC7799843     

Source DB:  PubMed          Journal:  AJSP Rev Rep        ISSN： 2381-5949


  25 in total

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Authors:  Christian Steidl; Sohrab P Shah; Bruce W Woolcock; Lixin Rui; Masahiro Kawahara; Pedro Farinha; Nathalie A Johnson; Yongjun Zhao; Adele Telenius; Susana Ben Neriah; Andrew McPherson; Barbara Meissner; Ujunwa C Okoye; Arjan Diepstra; Anke van den Berg; Mark Sun; Gillian Leung; Steven J Jones; Joseph M Connors; David G Huntsman; Kerry J Savage; Lisa M Rimsza; Douglas E Horsman; Louis M Staudt; Ulrich Steidl; Marco A Marra; Randy D Gascoyne
Journal:  Nature       Date:  2011-03-02       Impact factor: 49.962

2.  Grey zone lymphoma with features intermediate between diffuse large B-cell lymphoma and classical Hodgkin lymphoma: a clinicopathological study of 14 Epstein-Barr virus-positive cases.

Authors:  Ahmed A Elsayed; Akira Satou; Ahmed E Eladl; Seiichi Kato; Shigeo Nakamura; Naoko Asano
Journal:  Histopathology       Date:  2016-12-16       Impact factor: 5.087

3.  EBV-positive large B-cell lymphomas in young patients: a nodal lymphoma with evidence for a tolerogenic immune environment.

Authors:  Alina Nicolae; Stefania Pittaluga; Shahed Abdullah; Seth M Steinberg; Thu Anh Pham; Theresa Davies-Hill; Liqiang Xi; Mark Raffeld; Elaine S Jaffe
Journal:  Blood       Date:  2015-05-21       Impact factor: 22.113

Review 4.  Checkpoint blockade in Hodgkin and non-Hodgkin lymphoma.

Authors:  Reid W Merryman; Philippe Armand; Kyle T Wright; Scott J Rodig
Journal:  Blood Adv       Date:  2017-12-12

5.  Origin of the Hodgkin/Reed-Sternberg cells in chronic lymphocytic leukemia with "Hodgkin's transformation".

Authors:  T Ohno; B N Smir; D D Weisenburger; R D Gascoyne; S D Hinrichs; W C Chan
Journal:  Blood       Date:  1998-03-01       Impact factor: 22.113

6.  Relationship between the mutational status of VH genes and pathogenesis of diffuse large B-cell lymphoma in Richter's syndrome.

Authors:  B Timár; Z Fülöp; B Csernus; C Angster; A Bognár; A Szepesi; L Kopper; A Matolcsy
Journal:  Leukemia       Date:  2004-02       Impact factor: 11.528

7.  IgVH mutational status and clonality analysis of Richter's transformation: diffuse large B-cell lymphoma and Hodgkin lymphoma in association with B-cell chronic lymphocytic leukemia (B-CLL) represent 2 different pathways of disease evolution.

Authors:  Zhengrong Mao; Leticia Quintanilla-Martinez; Mark Raffeld; Manfred Richter; Jens Krugmann; Christof Burek; Elena Hartmann; Thomas Rudiger; Elaine S Jaffe; Hans Konrad Müller-Hermelink; German Ott; Falko Fend; Andreas Rosenwald
Journal:  Am J Surg Pathol       Date:  2007-10       Impact factor: 6.394

8.  Hodgkin lymphoma variant of Richter transformation: morphology, Epstein-Barr virus status, clonality, and survival analysis-with comparison to Hodgkin-like lesion.

Authors:  Wenbin Xiao; Wayne W Chen; Lynn Sorbara; Theresa Davies-Hill; Stefania Pittaluga; Mark Raffeld; Elaine S Jaffe
Journal:  Hum Pathol       Date:  2016-05-14       Impact factor: 3.466

Review 9.  Development of PD-1 and PD-L1 inhibitors as a form of cancer immunotherapy: a comprehensive review of registration trials and future considerations.

Authors:  Jun Gong; Alexander Chehrazi-Raffle; Srikanth Reddi; Ravi Salgia
Journal:  J Immunother Cancer       Date:  2018-01-23       Impact factor: 13.751

10.  Secondary B-cell lymphoma associated with the Epstein-Barr virus in chronic lymphocytic leukemia patients.

Authors:  Julie Morscio; Emilie Bittoun; Nathalie Volders; Eveline Lurquin; Iwona Wlodarska; Olivier Gheysens; Peter Vandenberghe; Gregor Verhoef; Philippe Demaerel; Daan Dierickx; Xavier Sagaert; Ann Janssens; Thomas Tousseyn
Journal:  J Hematop       Date:  2016-05-21       Impact factor: 0.196
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