Literature DB >> 33436690

Synthesis and tumour cell uptake studies of gadolinium(III)-phosphonium complexes.

Andrew J Hall1, Amy G Robertson1, Leila R Hill1, Louis M Rendina2,3.   

Abstract

The synthesis of a new series of Gd(III)-arylphosphonium complexes is described and the solution stability of selected compounds is reported. Their lipophilicity and uptake in human glial (SVG p12) and human glioblastoma multiforme (T98G) cell lines are presented. The in vitro cytotoxicity of all complexes was determined to be low at therapeutically-relevant concentrations. Selected Gd(III) complexes are potential candidates for further investigation as theranostic agents.

Entities:  

Year:  2021        PMID： 33436690      PMCID： PMC7804430          DOI： 10.1038/s41598-020-79893-9

Source DB:  PubMed          Journal:  Sci Rep        ISSN： 2045-2322            Impact factor:   4.379


  38 in total

1.  Lipophilicity in drug discovery.

Authors:  Michael J Waring
Journal:  Expert Opin Drug Discov       Date:  2010-03       Impact factor: 6.098

2.  No Signal Intensity Increase in the Dentate Nucleus on Unenhanced T1-weighted MR Images after More than 20 Serial Injections of Macrocyclic Gadolinium-based Contrast Agents.

Authors:  Alexander Radbruch; Robert Haase; Pascal J Kieslich; Lukas D Weberling; Philipp Kickingereder; Wolfgang Wick; Heinz-Peter Schlemmer; Martin Bendszus
Journal:  Radiology       Date:  2016-12-07       Impact factor: 11.105

3.  Synthesis and stability studies of Ga-67 labeled phosphonium salts.

Authors:  Mingyue Kardashinsky; Nigel Lengkeek; Louis M Rendina
Journal:  J Labelled Comp Radiopharm       Date:  2016-11-07       Impact factor: 1.921

4.  Mechanism of coupling of oxidative phosphorylation and the membrane potential of mitochondria.

Authors:  E A Liberman; V P Topaly; L M Tsofina; A A Jasaitis; V P Skulachev
Journal:  Nature       Date:  1969-06-14       Impact factor: 49.962

5.  Intracranial Gadolinium Deposition after Contrast-enhanced MR Imaging.

Authors:  Robert J McDonald; Jennifer S McDonald; David F Kallmes; Mark E Jentoft; David L Murray; Kent R Thielen; Eric E Williamson; Laurence J Eckel
Journal:  Radiology       Date:  2015-03-05       Impact factor: 11.105

6.  Macrocyclic and Other Non-Group 1 Gadolinium Contrast Agents Deposit Low Levels of Gadolinium in Brain and Bone Tissue: Preliminary Results From 9 Patients With Normal Renal Function.

Authors:  Nozomu Murata; Luis F Gonzalez-Cuyar; Kiyoko Murata; Corinne Fligner; Russell Dills; Daniel Hippe; Kenneth R Maravilla
Journal:  Invest Radiol       Date:  2016-07       Impact factor: 6.016

7.  Preferential accumulation of (3)H-tetraphenylphosphonium in non-small cell lung carcinoma in mice: comparison with (99m)Tc-MIBI.

Authors:  Igal Madar; Lola Weiss; Gabriel Izbicki
Journal:  J Nucl Med       Date:  2002-02       Impact factor: 10.057

8.  Motexafin gadolinium generates reactive oxygen species and induces apoptosis in sensitive and highly resistant multiple myeloma cells.

Authors:  Andrew M Evens; Philip Lecane; Darren Magda; Sheila Prachand; Seema Singhal; Jeff Nelson; Richard A Miller; Ronald B Gartenhaus; Leo I Gordon
Journal:  Blood       Date:  2004-09-23       Impact factor: 22.113

9.  High signal intensity in the dentate nucleus and globus pallidus on unenhanced T1-weighted MR images: relationship with increasing cumulative dose of a gadolinium-based contrast material.

Authors:  Tomonori Kanda; Kazunari Ishii; Hiroki Kawaguchi; Kazuhiro Kitajima; Daisuke Takenaka
Journal:  Radiology       Date:  2013-12-07       Impact factor: 11.105

10.  T1-Weighted Hypersignal in the Deep Cerebellar Nuclei After Repeated Administrations of Gadolinium-Based Contrast Agents in Healthy Rats: Difference Between Linear and Macrocyclic Agents.

Authors:  Philippe Robert; Stéphane Lehericy; Sylvie Grand; Xavier Violas; Nathalie Fretellier; Jean-Marc Idée; Sébastien Ballet; Claire Corot
Journal:  Invest Radiol       Date:  2015-08       Impact factor: 6.016
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  2 in total

1.  Fluorescently Labeled Gadolinium Ferrate/Trigadolinium Pentairon(III) Oxide Nanoparticles: Synthesis, Characterization, In Vivo Biodistribution, and Application for Visualization of Myocardial Ischemia-Reperfusion Injury.

Authors:  Dmitry V Korolev; Galina A Shulmeyster; Maria S Istomina; Natalia V Evreinova; Ilia V Aleksandrov; Aleksandr S Krasichkov; Viktor N Postnov; Michael M Galagudza
Journal:  Materials (Basel)       Date:  2022-05-27       Impact factor: 3.748

2.  Using ELP Repeats as a Scaffold for De Novo Construction of Gadolinium-Binding Domains within Multifunctional Recombinant Proteins for Targeted Delivery of Gadolinium to Tumour Cells.

Authors:  Natalia V Pozdniakova; Oxana V Ryabaya; Alevtina S Semkina; Vsevolod A Skribitsky; Alexei B Shevelev
Journal:  Int J Mol Sci       Date:  2022-03-18       Impact factor: 5.923
  2 in total

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