| Literature DB >> 33431879 |
Jeroen J A van Kampen1, David A M C van de Vijver2, Pieter L A Fraaij2,3, Bart L Haagmans2, Mart M Lamers2, Nisreen Okba2, Johannes P C van den Akker4, Henrik Endeman4, Diederik A M P J Gommers4, Jan J Cornelissen5, Rogier A S Hoek6,7, Menno M van der Eerden6, Dennis A Hesselink7,8, Herold J Metselaar7,9, Annelies Verbon10, Jurriaan E M de Steenwinkel10, Georgina I Aron2, Eric C M van Gorp2, Sander van Boheemen2, Jolanda C Voermans2, Charles A B Boucher2, Richard Molenkamp2, Marion P G Koopmans2, Corine Geurtsvankessel2, Annemiek A van der Eijk2.
Abstract
Key questions in COVID-19 are the duration and determinants of infectious virus shedding. Here, we report that infectious virus shedding is detected by virus cultures in 23 of the 129 patients (17.8%) hospitalized with COVID-19. The median duration of shedding infectious virus is 8 days post onset of symptoms (IQR 5-11) and drops below 5% after 15.2 days post onset of symptoms (95% confidence interval (CI) 13.4-17.2). Multivariate analyses identify viral loads above 7 log10 RNA copies/mL (odds ratio [OR] of 14.7 (CI 3.57-58.1; p < 0.001) as independently associated with isolation of infectious SARS-CoV-2 from the respiratory tract. A serum neutralizing antibody titre of at least 1:20 (OR of 0.01 (CI 0.003-0.08; p < 0.001) is independently associated with non-infectious SARS-CoV-2. We conclude that quantitative viral RNA load assays and serological assays could be used in test-based strategies to discontinue or de-escalate infection prevention and control precautions.Entities:
Year: 2021 PMID： 33431879 DOI： 10.1038/s41467-020-20568-4
Source DB: PubMed Journal: Nat Commun ISSN： 2041-1723 Impact factor: 14.919