| Literature DB >> 33429995 |
Carrow I Wells1, Hassan Al-Ali2,3, David M Andrews4, Christopher R M Asquith1, Alison D Axtman1, Ivan Dikic5,6,7, Daniel Ebner8, Peter Ettmayer9, Christian Fischer10, Mathias Frederiksen11, Robert E Futrell1, Nathanael S Gray12,13, Stephanie B Hatch14, Stefan Knapp6,15,16, Ulrich Lücking17, Michael Michaelides18, Caitlin E Mills19, Susanne Müller6,15,16, Dafydd Owen20, Alfredo Picado1, Kumar S Saikatendu21, Martin Schröder6,15,16, Alexandra Stolz5,6,15, Mariana Tellechea5,6,15, Brandon J Turunen22, Santiago Vilar3, Jinhua Wang12,13, William J Zuercher1, Timothy M Willson1, David H Drewry1.
Abstract
We describe the assembly and annotation of a chemogenomic set of protein kinase inhibitors as an open science resource for studying kinase biology. The set only includes inhibitors that show potent kinase inhibition and a narrow spectrum of activity when screened across a large panel of kinase biochemical assays. Currently, the set contains 187 inhibitors that cover 215 human kinases. The kinase chemogenomic set (KCGS), current Version 1.0, is the most highly annotated set of selective kinase inhibitors available to researchers for use in cell-based screens.Entities:
Keywords: KCGS; chemogenomic set; drug discovery; druggable genome; kinase inhibitor; phenotypic screening; protein kinase; small molecules; understudied kinase
Year: 2021 PMID： 33429995 DOI： 10.3390/ijms22020566
Source DB: PubMed Journal: Int J Mol Sci ISSN： 1422-0067 Impact factor: 5.923