Benedek Tinusz1, László Botond Szapáry1, Bence Paládi1, András Papp2, Barna Bogner3, Ivett Hegedűs3, Szabolcs Bellyei4, Áron Vincze5, Jenő Solt5, Tamás Micsik6, Veronika Dunás-Varga7, Eszter Pályu8, Tamás Vass9, Tamás Schnabel10, Nelli Farkas11, Péter Hegyi1, Aaron P Thrift12, Bálint Erőss1. 1. Medical School, Institute for Translational Medicine and Szentágothai Research Center, University of Pécs, Pécs, Hungary. 2. Department of Surgery, University of Pécs, Pécs, Hungary. 3. Department of Pathology, Medical School, University of Pécs, Pécs, Hungary. 4. Department of Oncotherapy, Medical School, University of Pécs, Pécs, Hungary. 5. Department of Gastroenterology, 1st Department of Medicine, Medical School, University of Pécs, Pécs, Hungary. 6. 1st Department of Pathology and Experimental Cancer Research, Semmelweis University, Budapest, Hungary. 7. 1st Department of Internal Medicine, Szent György University Teaching Hospital of Fejér County, Székesfehérvár, Hungary. 8. 2nd Department of Internal Medicine, University of Debrecen, Debrecen, Hungary. 9. 1st Department of Surgery, Semmelweis University, Budapest, Hungary. 10. Department of Gastroenterology, Saint John's Hospital, Budapest, Hungary. 11. Medical School, Institute of Bioanalysis, University of Pécs, Pécs, Hungary. 12. Department of Medicine and Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX, United States.
Abstract
BACKGROUND: The epidemiology of esophageal cancer has changed dramatically over the past 4 decades in many Western populations. We aimed to understand the Hungarian epidemiologic trends of esophageal squamous cell cancer (SCC) and adenocarcinoma (AC). METHODS: We performed a cross-sectional study using data from esophageal cancer patients diagnosed between 1992 and 2018 at eight tertiary referral centers in four major cities of Hungary. We retrospectively identified cases in the electronic databases of each center and collected data on gender, age at diagnosis, year of diagnosis, specialty of the origin center, histological type, and localization of the tumor. Patients were grouped based on the two main histological types: AC or SCC. For statistical analysis, we used linear regression models, chi-square tests, and independent sample t tests. RESULTS: We extracted data on 3,283 patients with esophageal cancer. Of these, 2,632 were diagnosed with either of the two main histological types; 737 had AC and 1,895 SCC. There was no significant difference in the gender ratio of the patients between AC and SCC (80.1 vs 81.8% males, respectively; p = 0.261). The relative incidence of AC increased over the years (p < 0.001, b = 1.19 CI: 0.84-1.54). AC patients were older at diagnosis than SCC patients (64.37 ± 11.59 vs 60.30 ± 10.07 years, p < 0.001). The age of patients at the diagnosis of primary esophageal cancer increased over time (p < 0.001, R = 0.119). CONCLUSIONS: The rapid increase in the relative incidence of AC and simultaneous decrease of the relative incidence of SCC suggest that this well-established Western phenomenon is also present in Hungary.
BACKGROUND: The epidemiology of esophageal cancer has changed dramatically over the past 4 decades in many Western populations. We aimed to understand the Hungarian epidemiologic trends of esophageal squamous cell cancer (SCC) and adenocarcinoma (AC). METHODS: We performed a cross-sectional study using data from esophageal cancer patients diagnosed between 1992 and 2018 at eight tertiary referral centers in four major cities of Hungary. We retrospectively identified cases in the electronic databases of each center and collected data on gender, age at diagnosis, year of diagnosis, specialty of the origin center, histological type, and localization of the tumor. Patients were grouped based on the two main histological types: AC or SCC. For statistical analysis, we used linear regression models, chi-square tests, and independent sample t tests. RESULTS: We extracted data on 3,283 patients with esophageal cancer. Of these, 2,632 were diagnosed with either of the two main histological types; 737 had AC and 1,895 SCC. There was no significant difference in the gender ratio of the patients between AC and SCC (80.1 vs 81.8% males, respectively; p = 0.261). The relative incidence of AC increased over the years (p < 0.001, b = 1.19 CI: 0.84-1.54). AC patients were older at diagnosis than SCC patients (64.37 ± 11.59 vs 60.30 ± 10.07 years, p < 0.001). The age of patients at the diagnosis of primary esophageal cancer increased over time (p < 0.001, R = 0.119). CONCLUSIONS: The rapid increase in the relative incidence of AC and simultaneous decrease of the relative incidence of SCC suggest that this well-established Western phenomenon is also present in Hungary.
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