Literature DB >> 334255

Allosteric regulation of aspartate transcarbamoylase. Changes in the sedimentation coefficient promoted by the bisubstrate analogue N-(phosphonacetyl)-L-aspartate.

G J Howlett, H K Schachman.   

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Year:  1977        PMID: 334255     DOI: 10.1021/bi00642a021

Source DB:  PubMed          Journal:  Biochemistry        ISSN: 0006-2960            Impact factor:   3.162


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  25 in total

1.  Binding of bisubstrate analog promotes large structural changes in the unregulated catalytic trimer of aspartate transcarbamoylase: implications for allosteric regulation.

Authors:  J A Endrizzi; P T Beernink; T Alber; H K Schachman
Journal:  Proc Natl Acad Sci U S A       Date:  2000-05-09       Impact factor: 11.205

2.  Random circular permutation leading to chain disruption within and near alpha helices in the catalytic chains of aspartate transcarbamoylase: effects on assembly, stability, and function.

Authors:  P T Beernink; Y R Yang; R Graf; D S King; S S Shah; H K Schachman
Journal:  Protein Sci       Date:  2001-03       Impact factor: 6.725

3.  In vivo assembly of aspartate transcarbamoylase from fragmented and circularly permuted catalytic polypeptide chains.

Authors:  X Ni; H K Schachman
Journal:  Protein Sci       Date:  2001-03       Impact factor: 6.725

4.  Substrate-induced conformational change in a trimeric ornithine transcarbamoylase.

Authors:  Y Ha; M T McCann; M Tuchman; N M Allewell
Journal:  Proc Natl Acad Sci U S A       Date:  1997-09-02       Impact factor: 11.205

5.  Structural transitions in crystals of native aspartate carbamoyltransferase.

Authors:  J E Gouaux; W N Lipscomb
Journal:  Proc Natl Acad Sci U S A       Date:  1989-02       Impact factor: 11.205

6.  Assessment of the allosteric mechanism of aspartate transcarbamoylase based on the crystalline structure of the unregulated catalytic subunit.

Authors:  P T Beernink; J A Endrizzi; T Alber; H K Schachman
Journal:  Proc Natl Acad Sci U S A       Date:  1999-05-11       Impact factor: 11.205

7.  Direct observation in solution of a preexisting structural equilibrium for a mutant of the allosteric aspartate transcarbamoylase.

Authors:  Luc Fetler; Evan R Kantrowitz; Patrice Vachette
Journal:  Proc Natl Acad Sci U S A       Date:  2007-01-03       Impact factor: 11.205

8.  Heterotropic interactions in aspartate transcarbamoylase: turning allosteric ATP activation into inhibition as a consequence of a single tyrosine to phenylalanine mutation.

Authors:  F Van Vliet; X G Xi; C De Staercke; B de Wannemaeker; A Jacobs; J Cherfils; M M Ladjimi; G Hervé; R Cunin
Journal:  Proc Natl Acad Sci U S A       Date:  1991-10-15       Impact factor: 11.205

9.  Role of a carboxyl-terminal helix in the assembly, interchain interactions, and stability of aspartate transcarbamoylase.

Authors:  C B Peterson; H K Schachman
Journal:  Proc Natl Acad Sci U S A       Date:  1991-01-15       Impact factor: 11.205

10.  Effect of amino acid substitutions on the catalytic and regulatory properties of aspartate transcarbamoylase.

Authors:  E A Robey; S R Wente; D W Markby; A Flint; Y R Yang; H K Schachman
Journal:  Proc Natl Acad Sci U S A       Date:  1986-08       Impact factor: 11.205

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