Dongjiang Xu1,2, Ke di Wang3, Jianhong Yang1. 1. Savaid Medical School, University of Chinese Academy of Sciences, Beijing 100049, China. 2. Department of Clinical Laboratory Medicine, Beijing Jishuitan Hospital, Beijing 100035, China. 3. Department of Clinical Laboratory Medicine, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
Abstract
PURPOSE: This study is aimed at exploring which indicator can predict the discordance between DXA and QCT. METHODS: 192 female patients who took BMD screening tests by QCT and DXA were recruited, and the biomarkers were analyzed to study the relationship between the biomarkers and the discordance of two BMD screening methods. RESULTS: There are 42, 78, and 72 female patients in the normal, osteopenia, and osteoporosis groups defined by DXA and 6, 54, and 132 female patients in the corresponding group defined by QCT. DXA was less sensitive than QCT. Cholesterol (CHO) and triglyceride (TG) were all negatively correlated with the discordance between these two methods. When TG > 0.89 mmol/L, the QCT result would be the same as the DXA's; otherwise, there should be discordance between QCT and DXA. CONCLUSIONS: Triglyceride can be used to predict the discordance between QCT and DXA, and clinicians can evaluate patients' DXA results based on patient triglyceride or cholesterol results as a supplement to QCT results.
PURPOSE: This study is aimed at exploring which indicator can predict the discordance between DXA and QCT. METHODS: 192 female patients who took BMD screening tests by QCT and DXA were recruited, and the biomarkers were analyzed to study the relationship between the biomarkers and the discordance of two BMD screening methods. RESULTS: There are 42, 78, and 72 female patients in the normal, osteopenia, and osteoporosis groups defined by DXA and 6, 54, and 132 female patients in the corresponding group defined by QCT. DXA was less sensitive than QCT. Cholesterol (CHO) and triglyceride (TG) were all negatively correlated with the discordance between these two methods. When TG > 0.89 mmol/L, the QCT result would be the same as the DXA's; otherwise, there should be discordance between QCT and DXA. CONCLUSIONS: Triglyceride can be used to predict the discordance between QCT and DXA, and clinicians can evaluate patients' DXA results based on patient triglyceride or cholesterol results as a supplement to QCT results.
Authors: Brandon B Carlson; Stephan N Salzmann; Toshiyuki Shirahata; Courtney Ortiz Miller; John A Carrino; Jingyan Yang; Marie-Jacqueline Reisener; Andrew A Sama; Frank P Cammisa; Federico P Girardi; Alexander P Hughes Journal: Neurosurg Focus Date: 2020-08 Impact factor: 4.047
Authors: Hoa Ton Kha; Benjamin Basseri; Daniel Shouhed; Jennifer Richardson; Sotirios Tetradis; Theodore J Hahn; Farhad Parhami Journal: J Bone Miner Res Date: 2004-01-12 Impact factor: 6.741
Authors: Hartmut H Malluche; Daniel L Davenport; Tom Cantor; Marie-Claude Monier-Faugere Journal: Clin J Am Soc Nephrol Date: 2014-06-19 Impact factor: 8.237
Authors: Maximilian T Löffler; Alina Jacob; Alexander Valentinitsch; Anna Rienmüller; Claus Zimmer; Yu-Mi Ryang; Thomas Baum; Jan S Kirschke Journal: Eur Radiol Date: 2019-02-21 Impact factor: 5.315