Melanie Smith Condeni1, Alyson T Basting2, Patrick G Costello3, Ashley DePriest4, Evert A Eriksson5, Heather Evans6, Kristie Hertel7, Andre L Holder8, Alyssa N Kester9, Kinsey R Kowalski10, Carolyn Magee Bell11, Barbara McLean12, Michael Reichert13, Melissa Santibañez14, Patrick M Wieruszewski15, Andrea Sikora Newsome16. 1. Medical University of South Carolina, 150 Ashley Avenue, Charleston, SC 29425, USA. Electronic address: smitmela@musc.edu. 2. Indiana University Health Arnett Hospital, 5165 McCarty Ln, Lafayette, IN 47905, USA. Electronic address: abasting@iuhealth.org. 3. University of Chicago Medical Center, 5841 S. Maryland Avenue, Chicago, IL 60637, USA. Electronic address: Patrick.Costello@uchospitals.edu. 4. Wellstar Kennestone Regional Medical Center, 677 Church Street, Marietta, GA 30060, USA. Electronic address: adepriest@gmh.edu. 5. Medical University of South Carolina, 96 Jonathan Lucas St, Charleston, SC 29425, USA. Electronic address: eriksson@musc.edu. 6. Medical University of South Carolina, 96 Jonathan Lucas St, Room CSB 426, Charleston, SC 29425, USA. Electronic address: evanshe@musc.edu. 7. Vidant Medical Center, 2100 Stantonsburg Road, Greenville, NC 27831, USA. 8. Emory University School of Medicine, Grady Memorial Hospital, 80 Jesse Hill Jr Drive SE, Rm 2D012, Atlanta, GA 30303, USA. Electronic address: Andre.holder@emory.edu. 9. St. Luke's University Health Network, 801 Ostrum Street, Bethlehem, PA 18015, USA. Electronic address: Alyssa.Kester@sluhn.org. 10. Ochsner Medical Center, 1514 Jefferson Highway, New Orleans, LA 70121, USA. Electronic address: Kinsey.kowalski@ochsner.org. 11. Medical University of South Carolina, 150 Ashley Ave MSC 584, Charleston, SC 29425, USA. Electronic address: mageeca@musc.edu. 12. Grady Health Systems, Atlanta, GA 30303, USA. 13. Emory Hillandale Hospital, 2801 Dekalb Medical Parkway, Lithonia, GA 30058, USA. 14. Larkin University, College of Pharmacy, 18301 North Miami Avenue, Miami, FL 33169, USA. Electronic address: msantibanez@ularkin.org. 15. Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA. Electronic address: wieruszewski.patrick@mayo.edu. 16. The University of Georgia College of Pharmacy, 1120 15(th) St, HM-118, Augusta, GA 30912, USA. Electronic address: sikora@uga.edu.
Abstract
PURPOSE: To summarize selected meta-analyses and trials related to critical care pharmacotherapy published in 2019. MATERIALS AND METHODS: The Critical Care Pharmacotherapy Literature Update (CCPLU) Group screened 36 journals monthly for impactful articles and reviewed 113 articles during 2019 according to Grading of Recommendations, Assessment, Development, and Evaluations (GRADE) criteria. RESULTS: Articles with a 1A grade, including three clinical practice guidelines, six meta-analyses, and five original research trials are reviewed here from those included in the monthly CCPLU. Clinical practice guidelines on the use of polymyxins and antiarrhythmic drugs in cardiac arrest as well as meta-analyses on antipsychotic use in delirium, stress ulcer prophylaxis (SUP), and vasoactive medications in septic shock and cardiac arrest were summarized. Original research trials evaluated delirium, sedation, neuromuscular blockade, SUP, anticoagulation reversal, and hemostasis. CONCLUSION: This clinical review and expert opinion provides summary and perspectives of clinical practice impact on influential critical care pharmacotherapy publications in 2019.
PURPOSE: To summarize selected meta-analyses and trials related to critical care pharmacotherapy published in 2019. MATERIALS AND METHODS: The Critical Care Pharmacotherapy Literature Update (CCPLU) Group screened 36 journals monthly for impactful articles and reviewed 113 articles during 2019 according to Grading of Recommendations, Assessment, Development, and Evaluations (GRADE) criteria. RESULTS: Articles with a 1A grade, including three clinical practice guidelines, six meta-analyses, and five original research trials are reviewed here from those included in the monthly CCPLU. Clinical practice guidelines on the use of polymyxins and antiarrhythmic drugs in cardiac arrest as well as meta-analyses on antipsychotic use in delirium, stress ulcer prophylaxis (SUP), and vasoactive medications in septic shock and cardiac arrest were summarized. Original research trials evaluated delirium, sedation, neuromuscular blockade, SUP, anticoagulation reversal, and hemostasis. CONCLUSION: This clinical review and expert opinion provides summary and perspectives of clinical practice impact on influential critical care pharmacotherapy publications in 2019.
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