Deanna Horner1, Diana Altshuler2, Chris Droege3, Joel Feih4, Kevin Ferguson5, Mallory Fiorenza6, Kasey Greathouse7, Leslie Hamilton8, Caitlin Pfaff9, Lauren Roller10, Joanna Stollings11, Adrian Wong12. 1. United Healthcare Medicare and Retirement - Part D STARs, 2441 Warrenville Rd 5th floor, Lisle, IL 60532, United States. Electronic address: deanna_horner@uhc.com. 2. NYU Langone Medical Center, 550 First Ave, New York, NY 10016, United States. Electronic address: diana.altshuler@nyumc.org. 3. PGY2 Critical Care Pharmacy Residency, UC Health - University of Cincinnati Medical Center, 234 Goodman Street, Cincinnati, OH 45219, United States. Electronic address: christopher.droege@uchealth.com. 4. Froedtert & the Medical College of Wisconsin, 9200 W. Wisconsin Avenue, Milwaukee, WI 53226, United States. Electronic address: joel.feih@froedtert.com. 5. Critical Care, Tampa General Hospital, 1 Tampa General Circle, Tampa, FL 33606, United States. Electronic address: kferguson@tgh.org. 6. Lee Health, 2776 Cleveland Ave, Fort Myers, FL 33901, United States. Electronic address: mallory.fiorenza@LeeHealth.org. 7. Northwestern Memorial Hospital, 251 E Huron St., Chicago, IL 60611, United States. Electronic address: kgreatho@nm.org. 8. University of Tennessee Health Science Center, College of Pharmacy, 1924 Alcoa Highway, Box 117, Knoxville, TN 37920, United States. Electronic address: lhamilt4@uthsc.edu. 9. Emergency Medicine, UC Health - West Chester Hospital, 7700 University Drive, West Chester, OH 45069, United States. Electronic address: caitlin.pfaff@UCHealth.com. 10. Touro University California, 1310 Club Drive, Vallejo, CA 94592, United States. Electronic address: lauren.roller@tu.edu. 11. ICU Recovery Center, Vanderbilt University Medical Center, 1211 Medical Center Drive, Nashville, TN 37232, United States. Electronic address: joanna.stollings@vanderbilt.edu. 12. Outcomes Research and Pharmacy Informatics, Brigham and Women's Hospital/MCPHS University, 75 Francis Street, Boston, MA 02115, United States. Electronic address: awong22@partners.org.
Abstract
PURPOSE: To summarize select critical care pharmacotherapy guidelines and studies published in 2016. SUMMARY: The Critical Care Pharmacotherapy Literature Update (CCPLU) Group screened 31 journals monthly for relevant pharmacotherapy articles and selected 107 articles for review over the course of 2016. Of those included in the monthly CCPLU, three guidelines and seven primary literature studies are reviewed here. The guideline updates included are as follows: hospital-acquired pneumonia and ventilator-associated pneumonia management, sustained neuromuscular blocking agent use, and reversal of antithrombotics in intracranial hemorrhage (ICH). The primary literature summaries evaluate the following: dexmedetomidine for delirium prevention in post-cardiac surgery, dexmedetomidine for delirium management in mechanically ventilated patients, high-dose epoetin alfa after out-of-hospital cardiac arrest, ideal blood pressure targets in ICH, hydrocortisone in severe sepsis, procalcitonin-guided antibiotic de-escalation, and empiric micafungin therapy. CONCLUSION: The review provides a synopsis of select pharmacotherapy publications in 2016 applicable to clinical practice.
PURPOSE: To summarize select critical care pharmacotherapy guidelines and studies published in 2016. SUMMARY: The Critical Care Pharmacotherapy Literature Update (CCPLU) Group screened 31 journals monthly for relevant pharmacotherapy articles and selected 107 articles for review over the course of 2016. Of those included in the monthly CCPLU, three guidelines and seven primary literature studies are reviewed here. The guideline updates included are as follows: hospital-acquired pneumonia and ventilator-associated pneumonia management, sustained neuromuscular blocking agent use, and reversal of antithrombotics in intracranial hemorrhage (ICH). The primary literature summaries evaluate the following: dexmedetomidine for delirium prevention in post-cardiac surgery, dexmedetomidine for delirium management in mechanically ventilated patients, high-dose epoetin alfa after out-of-hospital cardiac arrest, ideal blood pressure targets in ICH, hydrocortisone in severe sepsis, procalcitonin-guided antibiotic de-escalation, and empiric micafungin therapy. CONCLUSION: The review provides a synopsis of select pharmacotherapy publications in 2016 applicable to clinical practice.
Authors: Melanie Smith Condeni; Alyson T Basting; Patrick G Costello; Ashley DePriest; Evert A Eriksson; Heather Evans; Kristie Hertel; Andre L Holder; Alyssa N Kester; Kinsey R Kowalski; Carolyn Magee Bell; Barbara McLean; Michael Reichert; Melissa Santibañez; Patrick M Wieruszewski; Andrea Sikora Newsome Journal: J Crit Care Date: 2020-12-27 Impact factor: 3.425