Shahrzad Nazari1, Amirhossein Azari Jafari2, Seyyedmohammadsadeq Mirmoeeni2, Saeid Sadeghian3, Mohammad Eghbal Heidari4, Siavash Sadeghian5, Farhad Assarzadegan6, Seyed Mahmoud Puormand7, Hamid Ebadi8, Davood Fathi9,10, Sahar Dalvand11. 1. Department of Neuroscience and Addiction Studies, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran. 2. Student Research Committee, School of Medicine, Shahroud University of Medical Sciences, Shahroud, Iran. 3. Department of Paediatric Neurology, Golestan Medical, Educational, and Research Centre, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. 4. Students Scientific Research Center, Tehran University Medical Science, Tehran, Iran. 5. Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. 6. Department of Neurology, Imam Hossein Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran. 7. Imam Hossein Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran. 8. Department of Clinical Neurosciences, University of Calgary, Calgary, AB, Canada. 9. Brain and Spinal Cord Injury Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran. 10. Department of Neurology, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran. 11. Functional Neurosurgery Research Center, Shohada Tajrish Comprehensive Neurosurgical Center of Excellence, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Abstract
BACKGROUND: At the end of December 2019, a novel respiratory infection, initially reported in China, known as COVID-19 initially reported in China, and later known as COVID-19, led to a global pandemic. Despite many studies reporting respiratory infections as the primary manifestations of this illness, an increasing number of investigations have focused on the central nervous system (CNS) manifestations in COVID-19. In this study, we aimed to evaluate the CNS presentations in COVID-19 patients in an attempt to identify the common CNS features and provide a better overview to tackle this new pandemic. METHODS: In this systematic review and meta-analysis, we searched PubMed, Web of Science, Ovid, EMBASE, Scopus, and Google Scholar. Included studies were publications that reported the CNS features between 1 January 2020 and 20 April 2020. The data of selected studies were screened and extracted independently by four reviewers. Extracted data analyzed by using STATA statistical software. The study protocol registered with PROSPERO (CRD42020184456). RESULTS: Of 2,353 retrieved studies, we selected 64 studies with 11,687 patients after screening. Most of the studies were conducted in China (58 studies). The most common CNS symptom of COVID-19 was headache (8.69%, 95%CI: 6.76%-10.82%), dizziness (5.94%, 95%CI: 3.66%-8.22%), and impaired consciousness (1.90%, 95%CI: 1.0%-2.79%). CONCLUSIONS: The growing number of studies has reported COVID-19, CNS presentations as remarkable manifestations that happen. Hence, understanding the CNS characteristics of COVID-19 can help us for better diagnosis and ultimately prevention of worse outcomes.
BACKGROUND: At the end of December 2019, a novel respiratory infection, initially reported in China, known as COVID-19 initially reported in China, and later known as COVID-19, led to a global pandemic. Despite many studies reporting respiratory infections as the primary manifestations of this illness, an increasing number of investigations have focused on the central nervous system (CNS) manifestations in COVID-19. In this study, we aimed to evaluate the CNS presentations in COVID-19 patients in an attempt to identify the common CNS features and provide a better overview to tackle this new pandemic. METHODS: In this systematic review and meta-analysis, we searched PubMed, Web of Science, Ovid, EMBASE, Scopus, and Google Scholar. Included studies were publications that reported the CNS features between 1 January 2020 and 20 April 2020. The data of selected studies were screened and extracted independently by four reviewers. Extracted data analyzed by using STATA statistical software. The study protocol registered with PROSPERO (CRD42020184456). RESULTS: Of 2,353 retrieved studies, we selected 64 studies with 11,687 patients after screening. Most of the studies were conducted in China (58 studies). The most common CNS symptom of COVID-19 was headache (8.69%, 95%CI: 6.76%-10.82%), dizziness (5.94%, 95%CI: 3.66%-8.22%), and impaired consciousness (1.90%, 95%CI: 1.0%-2.79%). CONCLUSIONS: The growing number of studies has reported COVID-19, CNS presentations as remarkable manifestations that happen. Hence, understanding the CNS characteristics of COVID-19 can help us for better diagnosis and ultimately prevention of worse outcomes.
Authors: Lowell Ling; Christina So; Hoi Ping Shum; Paul K S Chan; Christopher K C Lai; Darshana H Kandamby; Eunise Ho; Dominic So; Wing Wa Yan; Grace Lui; Wai Shing Leung; Man Chun Chan; Charles D Gomersall Journal: Crit Care Resusc Date: 2020-04-06 Impact factor: 2.159
Authors: Flávio A Carvalho; Tenille Bernardino; Ricardo O H Maciel; Sérgio F A Felizola; Eduardo L V Costa; Gisele S Silva Journal: Case Rep Neurol Date: 2011-02-23
Authors: Bhagteshwar Singh; Suzannah Lant; Sofia Cividini; Jonathan W S Cattrall; Lynsey C Goodwin; Laura Benjamin; Benedict D Michael; Ayaz Khawaja; Aline de Moura Brasil Matos; Walid Alkeridy; Andrea Pilotto; Durjoy Lahiri; Rebecca Rawlinson; Sithembinkosi Mhlanga; Evelyn C Lopez; Brendan F Sargent; Anushri Somasundaran; Arina Tamborska; Glynn Webb; Komal Younas; Yaqub Al Sami; Heavenna Babu; Tristan Banks; Francesco Cavallieri; Matthew Cohen; Emma Davies; Shalley Dhar; Anna Fajardo Modol; Hamzah Farooq; Jeffrey Harte; Samuel Hey; Albert Joseph; Dileep Karthikappallil; Daniel Kassahun; Gareth Lipunga; Rachel Mason; Thomas Minton; Gabrielle Mond; Joseph Poxon; Sophie Rabas; Germander Soothill; Marialuisa Zedde; Konstantin Yenkoyan; Bruce Brew; Erika Contini; Lucette Cysique; Xin Zhang; Pietro Maggi; Vincent van Pesch; Jérome Lechien; Sven Saussez; Alex Heyse; Maria Lúcia Brito Ferreira; Cristiane N Soares; Isabel Elicer; Laura Eugenín-von Bernhardi; Waleng Ñancupil Reyes; Rong Yin; Mohammed A Azab; Foad Abd-Allah; Ahmed Elkady; Simon Escalard; Jean-Christophe Corvol; Cécile Delorme; Pierre Tattevin; Kévin Bigaut; Norbert Lorenz; Daniel Hornuss; Jonas Hosp; Siegbert Rieg; Dirk Wagner; Benjamin Knier; Paul Lingor; Andrea Sylvia Winkler; Athena Sharifi-Razavi; Shima T Moein; SeyedAhmad SeyedAlinaghi; Saeidreza JamaliMoghadamSiahkali; Mauro Morassi; Alessandro Padovani; Marcello Giunta; Ilenia Libri; Simone Beretta; Sabrina Ravaglia; Matteo Foschi; Paolo Calabresi; Guido Primiano; Serenella Servidei; Nicola Biagio Mercuri; Claudio Liguori; Mariangela Pierantozzi; Loredana Sarmati; Federica Boso; Silvia Garazzino; Sara Mariotto; Kimani N Patrick; Oana Costache; Alexander Pincherle; Frederikus A Klok; Roger Meza; Verónica Cabreira; Sofia R Valdoleiros; Vanessa Oliveira; Igor Kaimovsky; Alla Guekht; Jasmine Koh; Eva Fernández Díaz; José María Barrios-López; Cristina Guijarro-Castro; Álvaro Beltrán-Corbellini; Javier Martínez-Poles; Alba María Diezma-Martín; Maria Isabel Morales-Casado; Sergio García García; Gautier Breville; Matteo Coen; Marjolaine Uginet; Raphaël Bernard-Valnet; Renaud Du Pasquier; Yildiz Kaya; Loay H Abdelnour; Claire Rice; Hamish Morrison; Sylviane Defres; Saif Huda; Noelle Enright; Jane Hassell; Lucio D'Anna; Matthew Benger; Laszlo Sztriha; Eamon Raith; Krishna Chinthapalli; Ross Nortley; Ross Paterson; Arvind Chandratheva; David J Werring; Samir Dervisevic; Kirsty Harkness; Ashwin Pinto; Dinesh Jillella; Scott Beach; Kulothungan Gunasekaran; Ivan Rocha Ferreira Da Silva; Krishna Nalleballe; Jonathan Santoro; Tyler Scullen; Lora Kahn; Carla Y Kim; Kiran T Thakur; Rajan Jain; Thirugnanam Umapathi; Timothy R Nicholson; James J Sejvar; Eva Maria Hodel; Catrin Tudur Smith; Tom Solomon Journal: PLoS One Date: 2022-06-02 Impact factor: 3.752
Authors: Pyeong Hwa Kim; Minjae Kim; Chong Hyun Suh; Sae Rom Chung; Ji Eun Park; Soo Chin Kim; Young Jun Choi; Jeong Hyun Lee; Ho Sung Kim; Jung Hwan Baek; Choong Gon Choi; Sang Joon Kim Journal: Korean J Radiol Date: 2021-07-01 Impact factor: 3.500