Literature DB >> 33419152

Erectile Dysfunction Treatment Using Stem Cells: A Review.

Vassilis Protogerou1,2, Dimosthenis Chrysikos1, Vasileios Karampelias3, Ypatios Spanidis3, El Bisari Sara1, Theodoros Troupis1.   

Abstract

Erectile dysfunction (ED) is a disorder that affects the quality of life and the sexual relations of more than half of the male population aged over 40 years. The prediction regarding the incidence of ED is devastating as it is expected that this disorder will affect more than 300 million men in the next five years. Several studies have suggested the use of stem cells for the treatment of ED and showed that this type of treatment is promising in terms of damaged tissue repair as well as of clinical efficacy; however, there are several gaps in the knowledge and evidence is lacking. In order to highlight a few of them in this review, we performed a research of the literature focusing on currently available clinical studies regarding the clinical efficacy of stem cell administration for the treatment of ED. We reviewed the methods of administration, the cell types used in the performed clinical trials and the safety and efficiency of such procedures. We conclude that there are rapidly expanding and promising results from the reported clinical studies indicating that stem cells could indeed be a potential treatment for patients with ED although more studies are necessary.

Entities:  

Keywords:  adipose tissue-derived stem cell (ADSC); bone marrow-derived stem cell (BMSC); erectile dysfunction; novel treatments; platelet lysate plasma (PLP); platelet rich plasma (PRP); stem cells

Year:  2021        PMID: 33419152      PMCID: PMC7825548          DOI: 10.3390/medicines8010002

Source DB:  PubMed          Journal:  Medicines (Basel)        ISSN: 2305-6320


  52 in total

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Authors:  I A Ayta; J B McKinlay; R J Krane
Journal:  BJU Int       Date:  1999-07       Impact factor: 5.588

Review 2.  The role of nitric oxide in penile erection.

Authors:  J Cartledge; S Minhas; I Eardley
Journal:  Expert Opin Pharmacother       Date:  2001-01       Impact factor: 3.889

Review 3.  Stem cells: novel players in the treatment of erectile dysfunction.

Authors:  Haiyang Zhang; Maarten Albersen; Xunbo Jin; Guiting Lin
Journal:  Asian J Androl       Date:  2011-10-17       Impact factor: 3.285

Review 4.  Embryonic stem cell differentiation: emergence of a new era in biology and medicine.

Authors:  Gordon Keller
Journal:  Genes Dev       Date:  2005-05-15       Impact factor: 11.361

Review 5.  Mesenchymal stem cells in health and disease.

Authors:  Antonio Uccelli; Lorenzo Moretta; Vito Pistoia
Journal:  Nat Rev Immunol       Date:  2008-09       Impact factor: 53.106

6.  Intracavernous Injections of Bone Marrow Mononucleated Cells for Postradical Prostatectomy Erectile Dysfunction: Final Results of the INSTIN Clinical Trial.

Authors:  René Yiou; Leila Hamidou; Brigitte Birebent; Dalila Bitari; Philippe Le Corvoisier; Isabelle Contremoulins; Anne-Marie Rodriguez; Déborah Augustin; Françoise Roudot-Thoraval; Alexandre de la Taille; Hélène Rouard
Journal:  Eur Urol Focus       Date:  2017-06-24

7.  Comparative analysis of periprostatic implantation and intracavernosal injection of human adipose tissue-derived stem cells for erectile function recovery in a rat model of cavernous nerve injury.

Authors:  Dalsan You; Myoung Jin Jang; Jiyeon Lee; Nayoung Suh; In Gab Jeong; Dong Wan Sohn; Sae Woong Kim; Tai Young Ahn; Choung-Soo Kim
Journal:  Prostate       Date:  2012-07-20       Impact factor: 4.104

8.  Effects of transplantation of adipose tissue-derived stem cells on prostate tumor.

Authors:  Guiting Lin; Rong Yang; Lia Banie; Guifang Wang; Hongxiu Ning; Long-Cheng Li; Tom F Lue; Ching-Shwun Lin
Journal:  Prostate       Date:  2010-07-01       Impact factor: 4.104

9.  The PDE5 inhibitor sildenafil increases circulating endothelial progenitor cells and CXCR4 expression.

Authors:  Carlo Foresta; Luca De Toni; Antonella Di Mambro; Andrea Garolla; Alberto Ferlin; Daniela Zuccarello
Journal:  J Sex Med       Date:  2008-09-24       Impact factor: 3.802

Review 10.  The Use of Stromal Vascular Fraction in the Treatment of Male Sexual Dysfunction: A Review of Preclinical and Clinical Studies.

Authors:  Nora M Haney; Andrew Gabrielson; Taylor P Kohn; Wayne J G Hellstrom
Journal:  Sex Med Rev       Date:  2018-06-28
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  2 in total

1.  A case report of pudendal arteries angioplasty with sirolimus drug-coated balloon and drug-eluting stent associated with intracavernous autologous peripheral blood mononuclear cells injection for untreatable vasculogenic erectile dysfunction.

Authors:  Giuseppe Terlizzese; Robert Stubinski; Andrea Casini; Giacomo Clerici; Giuseppe Sangiorgi
Journal:  Eur Heart J Case Rep       Date:  2021-08-15

Review 2.  Is there a role for stem cell therapy in erectile dysfunction secondary to cavernous nerve injury? Network meta-analysis from animal studies and human trials.

Authors:  Mudassir M Wani; Bhavan P Rai; William Richard Webb; Sanjeev Madaan
Journal:  Ther Adv Urol       Date:  2022-03-29
  2 in total

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