Matheus Santos de Sousa Fernandes1, Tayrine Figueira Ordônio2, Gabriela Carvalho Jurema Santos3, Lucas Eduardo R Santos1, Camila Tenório Calazans4, Dayane Aparecida Gomes1,5, Tony Meireles Santos1. 1. Neuropsquiatry and Behavior Science Postgraduate Program, Federal University of Pernambuco, Recife, PE, Brazil. 2. Laboratório de Imunopatologia Keizo Asami-LIKA, University of Pernambuco, Recife, PE, Brazil. 3. Academic Center of Vitoria de Santo Antão, Federal University of Pernambuco, PE, Brazil. 4. School of Physical Education, University of Pernambuco, Recife, PE, Brazil. 5. Department of Physiology and Pharmacology, Center of Biosciences, Federal University of Pernambuco, Recife, PE, Brazil.
Abstract
Background: Physical exercise (PE) has been associated with increase neuroplasticity, neurotrophic factors, and improvements in brain function. Objective: To evaluate the effects of different PE protocols on neuroplasticity components and brain function in a human and animal model. Methods: We conducted a systematic review process from November 2019 to January 2020 of the following databases: PubMed, ScienceDirect, SciELO, LILACS, and Scopus. A keyword combination referring to PE and neuroplasticity was included as part of a more thorough search process. From an initial number of 20,782 original articles, after reading the titles and abstracts, twenty-one original articles were included. Two investigators evaluated the abstract, the data of the study, the design, the sample size, the participant characteristics, and the PE protocol. Results: PE increases neuroplasticity via neurotrophic factors (BDNF, GDNF, and NGF) and receptor (TrkB and P75NTR) production providing improvements in neuroplasticity, and cognitive function (learning and memory) in human and animal models. Conclusion: PE was effective for increasing the production of neurotrophic factors, cell growth, and proliferation, as well as for improving brain functionality.
Background: Physical exercise (PE) has been associated with increase neuroplasticity, neurotrophic factors, and improvements in brain function. Objective: To evaluate the effects of different PE protocols on neuroplasticity components and brain function in a human and animal model. Methods: We conducted a systematic review process from November 2019 to January 2020 of the following databases: PubMed, ScienceDirect, SciELO, LILACS, and Scopus. A keyword combination referring to PE and neuroplasticity was included as part of a more thorough search process. From an initial number of 20,782 original articles, after reading the titles and abstracts, twenty-one original articles were included. Two investigators evaluated the abstract, the data of the study, the design, the sample size, the participant characteristics, and the PE protocol. Results:PE increases neuroplasticity via neurotrophic factors (BDNF, GDNF, and NGF) and receptor (TrkB and P75NTR) production providing improvements in neuroplasticity, and cognitive function (learning and memory) in human and animal models. Conclusion:PE was effective for increasing the production of neurotrophic factors, cell growth, and proliferation, as well as for improving brain functionality.
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