| Literature DB >> 33414498 |
Eva Velthorst1,2,3, Josephine Mollon4, Robin M Murray5, Lieuwe de Haan6,7, Inez Myin Germeys8, David C Glahn4, Celso Arango9, Els van der Ven10,11, Marta Di Forti12,13, Miguel Bernardo14, Sinan Guloksuz11,15, Philippe Delespaul11,16, Gisela Mezquida14, Silvia Amoretti14, Julio Bobes17, Pilar A Saiz17, María Paz García-Portilla17, José Luis Santos17,18,19, Estela Jiménez-López17,20, Julio Sanjuan21, Eduardo J Aguilar21, Manuel Arrojo22, Angel Carracedo23,24, Gonzalo López17, Javier González-Peñas17, Mara Parellada9, Cem Atbaşoğlu25, Meram Can Saka25, Alp Üçok26, Köksal Alptekin27,28, Berna Akdede27, Tolga Binbay27, Vesile Altınyazar29, Halis Ulaş27, Berna Yalınçetin28, Güvem Gümüş-Akay30,31, Burçin Cihan Beyaz32, Haldun Soygür33, Eylem Şahin Cankurtaran34, Semra Ulusoy Kaymak35, Nadja P Maric36, Marina M Mihaljevic36, Sanja Andric Petrovic37, Tijana Mirjanic38, Cristina Marta Del-Ben39, Laura Ferraro5, Charlotte Gayer-Anderson40, Peter B Jones41, Hannah E Jongsma41,42, James B Kirkbride42, Caterina La Cascia43, Antonio Lasalvia44, Sarah Tosato44, Pierre-Michel Llorca45, Paulo Rossi Menezes46, Craig Morgan40,47, Diego Quattrone12, Marco Menchetti48, Jean-Paul Selten11,49, Andrei Szöke50, Ilaria Tarricone51, Andrea Tortelli52, Philip McGuire5, Lucia Valmaggia53, Matthew J Kempton5, Mark van der Gaag54, Anita Riecher-Rössler55, Rodrigo A Bressan56, Neus Barrantes-Vidal57,58, Barnaby Nelson59,60, Patrick McGorry59,61, Chris Pantelis61, Marie-Odile Krebs62, Stephan Ruhrmann63, Gabriele Sachs64, Bart P F Rutten11, Jim van Os5,11,65, Behrooz Z Alizadeh66,67, Therese van Amelsvoort11, Agna A Bartels-Velthuis67, Richard Bruggeman67,68, Nico J van Beveren69,70,71, Jurjen J Luykx65,72,73, Wiepke Cahn65,74, Claudia J P Simons11,75, Rene S Kahn76,77, Frederike Schirmbeck6,7, Ruud van Winkel11,78, Abraham Reichenberg76,79.
Abstract
Important questions remain about the profile of cognitive impairment in psychotic disorders across adulthood and illness stages. The age-associated profile of familial impairments also remains unclear, as well as the effect of factors, such as symptoms, functioning, and medication. Using cross-sectional data from the EU-GEI and GROUP studies, comprising 8455 participants aged 18 to 65, we examined cognitive functioning across adulthood in patients with psychotic disorders (n = 2883), and their unaffected siblings (n = 2271), compared to controls (n = 3301). An abbreviated WAIS-III measured verbal knowledge, working memory, visuospatial processing, processing speed, and IQ. Patients showed medium to large deficits across all functions (ES range = -0.45 to -0.73, p < 0.001), while siblings showed small deficits on IQ, verbal knowledge, and working memory (ES = -0.14 to -0.33, p < 0.001). Magnitude of impairment was not associated with participant age, such that the size of impairment in older and younger patients did not significantly differ. However, first-episode patients performed worse than prodromal patients (ES range = -0.88 to -0.60, p < 0.001). Adjusting for cannabis use, symptom severity, and global functioning attenuated impairments in siblings, while deficits in patients remained statistically significant, albeit reduced by half (ES range = -0.13 to -0.38, p < 0.01). Antipsychotic medication also accounted for around half of the impairment in patients (ES range = -0.21 to -0.43, p < 0.01). Deficits in verbal knowledge, and working memory may specifically index familial, i.e., shared genetic and/or shared environmental, liability for psychotic disorders. Nevertheless, potentially modifiable illness-related factors account for a significant portion of the cognitive impairment in psychotic disorders.Entities:
Mesh：
Year: 2021 PMID： 33414498 DOI： 10.1038/s41380-020-00969-z
Source DB: PubMed Journal: Mol Psychiatry ISSN： 1359-4184 Impact factor: 15.992