Lucia Sideli1,2, Adriano Schimmenti3, Daniele La Barbera4, Caterina La Cascia4, Laura Ferraro4, Monica Aas2,5,6, Luis Alameda2,7, Eva Velthorst8,9,10, Helen L Fisher11,12, Vincenzo Caretti1, Giulia Trotta2, Giada Tripoli2,4, Diego Quattrone11, Charlotte Gayer-Anderson11,13, Fabio Seminerio4, Crocettarachele Sartorio4, Giovanna Marrazzo4, Antonio Lasalvia14, Sarah Tosato14, Ilaria Tarricone15, Domenico Berardi16, Giuseppe D'Andrea16, Celso Arango17, Manuel Arrojo18, Miguel Bernardo19, Julio Bobes20, Julio Sanjuán21, Jose Luis Santos22, Paulo Rossi Menezes23, Cristina Marta Del-Ben24, Hannah E Jongsma25,26, Peter B Jones27,28, James B Kirkbride25, Pierre-Michel Llorca28, Andrea Tortelli29, Baptiste Pignon30,31,32, Lieuwe de Haan33, Jean-Paul Selten34,35, Jim Van Os2,35,36, Bart P Rutten35, Marta Di Forti11, Craig Morgan12,13, Robin M Murray2. 1. Department of Human Science, LUMSA University, Rome, Italy. 2. Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, England. 3. Faculty of Human and Social Sciences, UKE - Kore University of Enna, Enna, Italy. 4. Department of Biomedicine, Neuroscience, and Advanced Diagnostic, University of Palermo, Palermo, Italy. 5. NORMENT, Centre for Research On Mental Disorders, Oslo University Hospital and University of Oslo, Norway. 6. Department of Mental Health Research and Development, Division of Mental Health and Addiction, Vestre Viken Hospital Trust, Norway. 7. Departamento de Psiquiatria, Centro Investigacion Biomedica en Red de Salud Mental (CIBERSAM), Instituto de Biomedicina de Sevilla (IBIS), Hospital Universitario Virgen del Rocio, Universidad de Sevilla, Sevilla, Spain. 8. Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, USA. 9. Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, New York, USA. 10. Early Psychosis Section, Department of Psychiatry, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands. 11. King's College London, Social, Genetic, & Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, London, England. 12. ESRC Centre for Society and Mental Health, King's College London, London, UK. 13. Department of Health Services and Population Research, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, England. 14. Section of Psychiatry, Department of Neuroscience, Biomedicine and Movement, University of Verona, Verona, Italy. 15. Department of Medical and Surgical Sciences, Alma Mater Studiorum - Bologna University, Italy. 16. Department of Biomedical and NeuroMotor Sciences, Psychiatry Unit, Alma Mater Studiorum Università di Bologna, Bologna, Italy. 17. Department of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón, School of Medicine, Universidad Complutense, ISGM, CIBERSAM, Madrid, Spain. 18. Department of Psychiatry, Psychiatric Genetic Group, Instituto de Investigación Sanitaria de Santiago de Compostela, Complejo Hospitalario Universitario de Santiago de Compostela, Santiago, Spain. 19. Barcelona Clinic Schizophrenia Unit, Hospital Clinic, Department of Medicine, Neuroscience Institute, University of Barcelona, Institut d'Investigacions Biomèdiques, August Pi I Sunyer, Centro de Investigación Biomédica en Red de Salud Mental, Barcelona, Spain. 20. Department of Medicine, Psychiatry Area, Universidad de Oviedo, ISPA, INEUROPA, CIBERSAM, Oviedo, Spain. 21. Department of Psychiatry, Centro de Investigación Biomédica en Red de Salud Mental, School of Medicine, Universidad de Valencia, Valencia, Spain. 22. Department of Psychiatry, Hospital "Virgen de la Luz", Cuenca, Spain. 23. Department of Preventive Medicine, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil. 24. Division of Psychiatry, Department of Neuroscience and Behaviour, Ribeirão Preto Medical School, Universidade de São Paulo, São Paulo, Brazil. 25. PsyLife Group, Division of Psychiatry, University College London, London, England. 26. Department of Psychiatry, University of Cambridge, Cambridge, England. 27. CAMEO Early Intervention Service, Cambridgeshire and Peterborough National Health Service Foundation Trust, Cambridge, England. 28. EA 7280 Npsydo, Université Clermont Auvergne, Clermont-Ferrand, France. 29. Establissement Public de Santé, Maison Blanche, Paris, France. 30. AP-HP, Groupe Hospitalier "Mondor," Pôle de Psychiatrie, Créteil, France. 31. Institut National de la Santé et de la Recherche Médicale, U955, Créteil, France. 32. Fondation Fondamental, Créteil, France. 33. Early Psychosis Section, Department of Psychiatry, Amsterdam UMC, Amsterdam, The Netherlands. 34. Institute for Mental Health, GGZ Rivierduinen, Leiden, The Netherlands. 35. Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University Medical Centre, Maastricht, The Netherlands. 36. Department Psychiatry, Utrecht University Medical Centre, Utrecht, The Netherlands.
Abstract
BACKGROUND AND HYPOTHESIS: Evidence suggests that childhood maltreatment (ie, childhood abuse and childhood neglect) affects educational attainment and cognition. However, the association between childhood maltreatment and Intelligence Quotient (IQ) seems stronger among controls compared to people with psychosis. We hypothesised that: the association between childhood maltreatment and poor cognition would be stronger among community controls than among people with first-episode of psychosis (FEP); compared to abuse, neglect would show stronger associations with educational attainment and cognition; the association between childhood maltreatment and IQ would be partially accounted for by other risk factors; and the association between childhood maltreatment, educational attainment, and IQ would be stronger among patients with affective psychoses compared to those with nonaffective psychoses. STUDY DESIGN: 829 patients with FEP and 1283 community controls from 16 EU-GEI sites were assessed for child maltreatment, education attainment, and IQ. STUDY RESULTS: In both the FEP and control group, childhood maltreatment was associated with lower educational attainment. The association between childhood maltreatment and lower IQ was robust to adjustment for confounders only among controls. Whereas childhood neglect was consistently associated with lower attainment and IQ in both groups, childhood abuse was associated with IQ only in controls. Among both patients with affective and nonaffective psychoses, negative associations between childhood maltreatment and educational attainment were observed, but the crude association with IQ was only evident in affective psychoses. CONCLUSIONS: Our findings underscore the role of childhood maltreatment in shaping academic outcomes and cognition of people with FEP as well as controls.
BACKGROUND AND HYPOTHESIS: Evidence suggests that childhood maltreatment (ie, childhood abuse and childhood neglect) affects educational attainment and cognition. However, the association between childhood maltreatment and Intelligence Quotient (IQ) seems stronger among controls compared to people with psychosis. We hypothesised that: the association between childhood maltreatment and poor cognition would be stronger among community controls than among people with first-episode of psychosis (FEP); compared to abuse, neglect would show stronger associations with educational attainment and cognition; the association between childhood maltreatment and IQ would be partially accounted for by other risk factors; and the association between childhood maltreatment, educational attainment, and IQ would be stronger among patients with affective psychoses compared to those with nonaffective psychoses. STUDY DESIGN: 829 patients with FEP and 1283 community controls from 16 EU-GEI sites were assessed for child maltreatment, education attainment, and IQ. STUDY RESULTS: In both the FEP and control group, childhood maltreatment was associated with lower educational attainment. The association between childhood maltreatment and lower IQ was robust to adjustment for confounders only among controls. Whereas childhood neglect was consistently associated with lower attainment and IQ in both groups, childhood abuse was associated with IQ only in controls. Among both patients with affective and nonaffective psychoses, negative associations between childhood maltreatment and educational attainment were observed, but the crude association with IQ was only evident in affective psychoses. CONCLUSIONS: Our findings underscore the role of childhood maltreatment in shaping academic outcomes and cognition of people with FEP as well as controls.
Authors: Raquelle I Mesholam-Gately; Anthony J Giuliano; Kirsten P Goff; Stephen V Faraone; Larry J Seidman Journal: Neuropsychology Date: 2009-05 Impact factor: 3.295
Authors: Craig Morgan; Paul Fearon; Julia Lappin; Margaret Heslin; Kim Donoghue; Ben Lomas; Ulrich Reininghaus; Adanna Onyejiaka; Tim Croudace; Peter B Jones; Robin M Murray; Gillian A Doody; Paola Dazzan Journal: Br J Psychiatry Date: 2017-06-22 Impact factor: 10.671
Authors: N Mørkved; E Johnsen; R A Kroken; R Gjestad; D Winje; J Thimm; F Fathian; M Rettenbacher; L G Anda; E M Løberg Journal: Schizophr Res Cogn Date: 2020-05-19