Merle S Losch1, Akash Swamy2,3, Adrian Elmi-Terander4,5, Erik Edström4,5, Benno H W Hendriks2,3, Jenny Dankelman2. 1. Department of Biomechanical Engineering, Delft University of Technology, Delft, The Netherlands. m.s.losch@tudelft.nl. 2. Department of Biomechanical Engineering, Delft University of Technology, Delft, The Netherlands. 3. Department of In-Body Systems, Philips Research, Royal Philips, NV, Eindhoven, The Netherlands. 4. Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden. 5. Department of Neurosurgery, Karolinska University Hospital, Stockholm, Sweden.
Abstract
BACKGROUND: The increased popularity of minimally invasive spinal surgery calls for a revision of guidance techniques to prevent injuries of nearby neural and vascular structures. Lipid content has previously been proposed as a distinguishing criterion for different bone tissues to provide guidance along the interface of cancellous and cortical bone. This study aims to investigate how fat is distributed throughout the spinal column to confirm or refute the suitability of lipid content for guidance purposes. RESULTS: Proton density fat fraction (PDFF) was assessed over all vertebral levels for six human cadavers between 53 and 92 years of age, based on fat and water MR images. According to their distance to the vertebra contour, the data points were grouped in five regions of interest (ROIs): cortical bone (-1 mm to 0 mm), pre-cortical zone (PCZ) 1-3 (0-1 mm; 1-2 mm; 2-3 mm), and cancellous bone ([Formula: see text] 3 mm). For PCZ1 vs. PCZ2, a significant difference in mean PDFF of between -7.59 pp and -4.39 pp on average was found. For cortical bone vs. PCZ1, a significant difference in mean PDFF of between -27.09 pp and -18.96 pp on average was found. CONCLUSION: A relationship between distance from the cortical bone boundary and lipid content could be established, paving the way for guidance techniques based on fat fraction detection for spinal surgery.
BACKGROUND: The increased popularity of minimally invasive spinal surgery calls for a revision of guidance techniques to prevent injuries of nearby neural and vascular structures. Lipid content has previously been proposed as a distinguishing criterion for different bone tissues to provide guidance along the interface of cancellous and cortical bone. This study aims to investigate how fat is distributed throughout the spinal column to confirm or refute the suitability of lipid content for guidance purposes. RESULTS: Proton density fat fraction (PDFF) was assessed over all vertebral levels for six human cadavers between 53 and 92 years of age, based on fat and water MR images. According to their distance to the vertebra contour, the data points were grouped in five regions of interest (ROIs): cortical bone (-1 mm to 0 mm), pre-cortical zone (PCZ) 1-3 (0-1 mm; 1-2 mm; 2-3 mm), and cancellous bone ([Formula: see text] 3 mm). For PCZ1 vs. PCZ2, a significant difference in mean PDFF of between -7.59 pp and -4.39 pp on average was found. For cortical bone vs. PCZ1, a significant difference in mean PDFF of between -27.09 pp and -18.96 pp on average was found. CONCLUSION: A relationship between distance from the cortical bone boundary and lipid content could be established, paving the way for guidance techniques based on fat fraction detection for spinal surgery.
Entities:
Keywords:
Bone detection; Lipid content; Magnetic resonance imaging; Minimally invasive spine surgery; Screw placement
Authors: Akash Swamy; Gustav Burström; Jarich W Spliethoff; Drazenko Babic; Stefan Ruschke; John M Racadio; Erik Edström; Adrian Elmi Terander; Jenny Dankelman; Benno H W Hendriks Journal: Biomed Opt Express Date: 2019-08-01 Impact factor: 3.732
Authors: Johannes Schindelin; Ignacio Arganda-Carreras; Erwin Frise; Verena Kaynig; Mark Longair; Tobias Pietzsch; Stephan Preibisch; Curtis Rueden; Stephan Saalfeld; Benjamin Schmid; Jean-Yves Tinevez; Daniel James White; Volker Hartenstein; Kevin Eliceiri; Pavel Tomancak; Albert Cardona Journal: Nat Methods Date: 2012-06-28 Impact factor: 28.547
Authors: Xiaojuan Li; Daniel Kuo; Anne L Schafer; Anne Porzig; Thomas M Link; Dennis Black; Ann V Schwartz Journal: J Magn Reson Imaging Date: 2011-04 Impact factor: 4.813
Authors: Gustav Burström; Akash Swamy; Jarich W Spliethoff; Christian Reich; Drazenko Babic; Benno H W Hendriks; Halldor Skulason; Oscar Persson; Adrian Elmi Terander; Erik Edström Journal: Biomed Opt Express Date: 2019-10-24 Impact factor: 3.732
Authors: Thomas Baum; Samuel P Yap; Dimitrios C Karampinos; Lorenzo Nardo; Daniel Kuo; Andrew J Burghardt; Umesh B Masharani; Ann V Schwartz; Xiaojuan Li; Thomas M Link Journal: J Magn Reson Imaging Date: 2011-08-16 Impact factor: 4.813
Authors: Thomas Baum; Alexander Rohrmeier; Jan Syväri; Maximilian N Diefenbach; Daniela Franz; Michael Dieckmeyer; Andreas Scharr; Hans Hauner; Stefan Ruschke; Jan S Kirschke; Dimitrios C Karampinos Journal: Front Endocrinol (Lausanne) Date: 2018-04-04 Impact factor: 5.555