| Literature DB >> 33412999 |
Zhi Liu1,2,3, Xuhua Mao4, Zhou Dan1,2,3,5, Yang Pei1,2,3, Rui Xu1,2,3, Mengchen Guo1,2,3, Kangjian Liu5, Faming Zhang5, Junyu Chen1,2,3, Chuan Su1,2, Yaoyao Zhuang1,2,3, Junming Tang4, Yankai Xia1, Lianhong Qin6, Zhibin Hu1, Xingyin Liu1,2,3,5.
Abstract
The genetic variations and dysbiosis of gut microbiota are associated with ASD. However, the role of the microbiota in the etiology of ASD in terms of host genetic susceptibility remains unclear. This study aims to systematically explore the interplay between host genetic variation and gut microbiota in ASD children. Whole-exon sequencing was applied to 26 ASD children and 26 matched controls to identify the single nucleotide variations (SNVs) in ASD. Our previous study revealed alteration in gut microbiota and disorder of metabolism activity in ASD for this cohort. Systematic bioinformatic analyses were further performed to identify associations between SNVs and gut microbiota, as well as their metabolites. The ASD SNVs were significantly enriched in genes associated with innate immune response, protein glycosylation process, and retrograde axonal transport. These SNVs were also correlated with the microbiome composition and a broad aspect of microbial functions, especially metabolism. Additionally, the abundance of metabolites involved in the metabolic network of neurotransmitters was inferred to be causally related to specific SNVs and microbes. Furthermore, our data suggested that the interaction of host genetics and gut microbes may play a crucial role in the immune and metabolism homeostasis of ASD. This study may provide valuable clues to investigate the interaction of host genetic variations and gut microbiota in the pathogenesis of ASD.Entities:
Keywords: Autism; cytokine; genetic variation; gut microbiota; metabolites
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Year: 2021 PMID： 33412999 PMCID： PMC7808426 DOI： 10.1080/19490976.2020.1854967
Source DB: PubMed Journal: Gut Microbes ISSN： 1949-0976