BACKGROUND: Drug costs are increasing in Europe, and there is a heightened need to reduce pressure on healthcare systems. In 2017, oncology, autoimmune disease, and diabetes featured as the three highest therapy areas for drug spend in the EU-28. However, the absolute 1-year drug spend growth for diabetes did not feature within the ten fastest growing therapy areas. OBJECTIVE: This study explores the association between drug spend and disease burden in oncology, autoimmune disease, and diabetes in the EU-28. METHODS: Oncology, autoimmune disease and diabetes therapeutic areas were investigated using four methodologies. Historical and forecasted drug spend was analysed using the IQVIA MIDAS® drug sales database. Clinical and economic burden was estimated from targeted literature reviews. Trend analyses compared changes in drug spend with clinical burden using the Global Burden of Disease tool as the epidemiological reference. Cost per quality-adjusted life-years (QALYs) from UK health technology assessments were compared to interpret the health economic value. RESULTS: Oncology had the highest historical drug spend and growth compared with autoimmune disease and diabetes. Total drug spend and growth in oncology is forecasted to exceed diabetes by twofold. Increasing oncology drug spend historically did not correspond with reductions in mortality and morbidity. Diabetes had the lowest drug spend and greatest QALY/€1000 spent benefit. CONCLUSION: This study indicates that drug spend may not correlate to clinical burden across diseases. Future research could stimulate debate on whether more equitable drug funding may improve disease management.
BACKGROUND: Drug costs are increasing in Europe, and there is a heightened need to reduce pressure on healthcare systems. In 2017, oncology, autoimmune disease, and diabetes featured as the three highest therapy areas for drug spend in the EU-28. However, the absolute 1-year drug spend growth for diabetes did not feature within the ten fastest growing therapy areas. OBJECTIVE: This study explores the association between drug spend and disease burden in oncology, autoimmune disease, and diabetes in the EU-28. METHODS: Oncology, autoimmune disease and diabetes therapeutic areas were investigated using four methodologies. Historical and forecasted drug spend was analysed using the IQVIA MIDAS® drug sales database. Clinical and economic burden was estimated from targeted literature reviews. Trend analyses compared changes in drug spend with clinical burden using the Global Burden of Disease tool as the epidemiological reference. Cost per quality-adjusted life-years (QALYs) from UK health technology assessments were compared to interpret the health economic value. RESULTS: Oncology had the highest historical drug spend and growth compared with autoimmune disease and diabetes. Total drug spend and growth in oncology is forecasted to exceed diabetes by twofold. Increasing oncology drug spend historically did not correspond with reductions in mortality and morbidity. Diabetes had the lowest drug spend and greatest QALY/€1000 spent benefit. CONCLUSION: This study indicates that drug spend may not correlate to clinical burden across diseases. Future research could stimulate debate on whether more equitable drug funding may improve disease management.
Authors: J Ferlay; E Steliarova-Foucher; J Lortet-Tieulent; S Rosso; J W W Coebergh; H Comber; D Forman; F Bray Journal: Eur J Cancer Date: 2013-02-26 Impact factor: 9.162
Authors: Brian Godman; Anna Bucsics; Patricia Vella Bonanno; Wija Oortwijn; Celia C Rothe; Alessandra Ferrario; Simone Bosselli; Andrew Hill; Antony P Martin; Steven Simoens; Amanj Kurdi; Mohamed Gad; Jolanta Gulbinovič; Angela Timoney; Tomasz Bochenek; Ahmed Salem; Iris Hoxha; Robert Sauermann; Amos Massele; Augusto Alfonso Guerra; Guenka Petrova; Zornitsa Mitkova; Gnosia Achniotou; Ott Laius; Catherine Sermet; Gisbert Selke; Vasileios Kourafalos; John Yfantopoulos; Einar Magnusson; Roberta Joppi; Margaret Oluka; Hye-Young Kwon; Arianit Jakupi; Francis Kalemeera; Joseph O Fadare; Oyvind Melien; Maciej Pomorski; Magdalene Wladysiuk; Vanda Marković-Peković; Ileana Mardare; Dmitry Meshkov; Tanja Novakovic; Jurij Fürst; Dominik Tomek; Corrine Zara; Eduardo Diogene; Johanna C Meyer; Rickard Malmström; Björn Wettermark; Zinhle Matsebula; Stephen Campbell; Alan Haycox Journal: Front Public Health Date: 2018-12-05
Authors: Jaime Espin; Michael Schlander; Brian Godman; Pippa Anderson; Jorge Mestre-Ferrandiz; Isabelle Borget; Adam Hutchings; Steven Flostrand; Adam Parnaby; Claudio Jommi Journal: Appl Health Econ Health Policy Date: 2018-12 Impact factor: 2.561