| Literature DB >> 33407903 |
Marjan Vandenabeele1,2, Lien Veys1,2, Sophie Lemmens3,4, Xavier Hadoux5,6, Géraldine Gelders1,2, Luca Masin1,2, Lutgarde Serneels2,7,8, Jan Theunis9, Takashi Saito10,11,12, Takaomi C Saido10, Murali Jayapala12, Patrick De Boever7,8,13,14, Bart De Strooper2,7,8, Ingeborg Stalmans3,4, Peter van Wijngaarden5,6, Lieve Moons1,2, Lies De Groef15,16.
Abstract
In this study, we report the results of a comprehensive phenotyping of the retina of the AppNL-G-F mouse. We demonstrate that soluble Aβ accumulation is present in the retina of these mice early in life and progresses to Aβ plaque formation by midlife. This rising Aβ burden coincides with local microglia reactivity, astrogliosis, and abnormalities in retinal vein morphology. Electrophysiological recordings revealed signs of neuronal dysfunction yet no overt neurodegeneration was observed and visual performance outcomes were unaffected in the AppNL-G-F mouse. Furthermore, we show that hyperspectral imaging can be used to quantify retinal Aβ, underscoring its potential as a biomarker for AD diagnosis and monitoring. These findings suggest that the AppNL-G-F retina mimics the early, preclinical stages of AD, and, together with retinal imaging techniques, offers unique opportunities for drug discovery and fundamental research into preclinical AD.Entities:
Keywords: Alzheimer’s disease; Electroretinogram; Hyperspectral imaging; Mouse model; Retina; Retinal imaging
Year: 2021 PMID： 33407903 PMCID： PMC7788955 DOI： 10.1186/s40478-020-01102-5
Source DB: PubMed Journal: Acta Neuropathol Commun ISSN： 2051-5960 Impact factor: 7.801