Literature DB >> 25833098

The Essential Role of Soluble Aβ Oligomers in Alzheimer's Disease.

Zi-Xuan Wang1, Lan Tan2, Jinyuan Liu3, Jin-Tai Yu4,5.   

Abstract

Alzheimer's disease (AD) is a common neurodegenerative disease characterized by amyloid plaque and neurofibrillary tangles (NFT). With the finding that soluble nonfibrillar Aβ levels actually correlate strongly with the severity of the disease, the initial focus on amyloid plaques shifted to the contemporary concept that AD memory failure is caused by soluble Aβ oligomers. The soluble Aβ are known to be more neurotoxicthan fibrillar Aβ species. In this paper, we summarize the essential role of soluble Aβ oligomers in AD and discuss therapeutic strategies that target soluble Aβ oligomers.

Entities:  

Keywords:  Alzheimer’ disease; Aβ; Soluble Aβ oligomers

Mesh：

Substances：

Year:  2015        PMID： 25833098     DOI： 10.1007/s12035-015-9143-0

Source DB:  PubMed          Journal:  Mol Neurobiol        ISSN： 0893-7648            Impact factor:   5.590


  207 in total

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Journal:  EMBO J       Date:  2011-03-25       Impact factor: 11.598

5.  beta-Amyloid(1-42) peptide directly modulates nicotinic receptors in the rat hippocampal slice.

Authors:  D L Pettit; Z Shao; J L Yakel
Journal:  J Neurosci       Date:  2001-01-01       Impact factor: 6.167

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Authors:  Alfredo J Miñano-Molina; Judit España; Elsa Martín; Bruna Barneda-Zahonero; Rut Fadó; Montse Solé; Ramón Trullás; Carlos A Saura; José Rodríguez-Alvarez
Journal:  J Biol Chem       Date:  2011-06-10       Impact factor: 5.157

7.  Amyloid-β-induced synapse damage is mediated via cross-linkage of cellular prion proteins.

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Journal:  J Biol Chem       Date:  2011-09-07       Impact factor: 5.157

8.  Alpha7-nicotinic acetylcholine receptors mediate an Abeta(1-42)-induced increase in the level of acetylcholinesterase in primary cortical neurones.

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  26 in total

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Review 3.  Targeting β-amyloid plaques and oligomers: development of near-IR fluorescence imaging probes.

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Review 5.  A Mitocentric View of Alzheimer's Disease.

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Journal:  Mol Neurobiol       Date:  2016-10-01       Impact factor: 5.590

6.  Chronic Hippocampal Expression of Notch Intracellular Domain Induces Vascular Thickening, Reduces Glucose Availability, and Exacerbates Spatial Memory Deficits in a Rat Model of Early Alzheimer.

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Journal:  Mol Neurobiol       Date:  2018-03-26       Impact factor: 5.590

Review 7.  A critical appraisal of amyloid-β-targeting therapies for Alzheimer disease.

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Review 9.  Involvement of Astrocytes in Alzheimer's Disease from a Neuroinflammatory and Oxidative Stress Perspective.

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Journal:  Front Mol Neurosci       Date:  2017-12-19       Impact factor: 5.639

Review 10.  Aβ Peptide Originated from Platelets Promises New Strategy in Anti-Alzheimer's Drug Development.

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Journal:  Biomed Res Int       Date:  2017-09-05       Impact factor: 3.411
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