Shu-Yu Hsieh1, Yu Zhi Lian1, I-Hsuan Lin2, Yu-Chen Yang3, Alexey A Tinkov4,5, Anatoly V Skalny4,5, Jane C-J Chao6,7,8. 1. School of Nutrition and Health Sciences, College of Nutrition, Taipei Medical University, 250 Wu-Hsing Street, Taipei 110, 11031, Taiwan. 2. Research Center of Translational Medicine, Taipei Medical University, Taipei 110, Taiwan. 3. Joint Biobank, Office of Human Research, Taipei Medical University, Taipei 110, Taiwan. 4. Sechenov First Moscow State Medical University, Moscow, Russia. 5. K.G. Razumovsky Moscow State University of Technologies and Management, Moscow, Russia. 6. School of Nutrition and Health Sciences, College of Nutrition, Taipei Medical University, 250 Wu-Hsing Street, Taipei 110, 11031, Taiwan. chenjui@tmu.edu.tw. 7. Master Program in Global Health and Development, Taipei Medical University, Taipei 110, Taiwan. chenjui@tmu.edu.tw. 8. Nutrition Research Center, Taipei Medical University Hospital, Taipei 110, Taiwan. chenjui@tmu.edu.tw.
Abstract
BACKGROUND: Non-steroidal anti-inflammatory drugs such as aspirin are used for the treatment of cardiovascular disease. Chronic use of low-dose aspirin is associated with the occurrence of gastric ulcer. The aim of this study was to investigate the healing potential of Lycium barbarum polysaccharides (LBP) from Chinese Goji berry and C-phycocyanin (CPC) from Spirulina platensis on gastric ulcer in rats. METHODS: Male Sprague-Dawley rats were divided into five groups: normal, aspirin (700 mg/kg bw), LBP (aspirin + 100 mg/kg bw/d LBP), CPC (aspirin + 50 mg/kg bw/d CPC), and MIX (aspirin + 50 mg/kg bw/d LBP + 25 mg/kg bw/d CPC) groups. Gastric ulcer was developed by daily oral feeding of aspirin for 8 weeks. Treatments were given orally a week before ulcer induction for 9 weeks. RESULTS: The MIX group elevated gastric cyclooxygenase-1, prostaglandin E2, and total nitrite and nitrate levels by 139%, 86%, and 66%, respectively, compared with the aspirin group (p < 0.05). Moreover, the MIX group reduced lipid peroxides malondialdehyde levels by 78% (p < 0.05). The treatment of LBP and/or CPC increased gastric Bifidobacterium relative abundance by 2.5-4.0 times compared with the aspirin group (p < 0.05). CONCLUSIONS: We conclude that combined LBP and CPC enhance gastroprotective factors, inhibit lipid peroxidation, and increase gastric Bifidobacterium relative abundance. Combined LBP and CPC have protective potential against gastric ulcer caused by aspirin in rats.
BACKGROUND: Non-steroidal anti-inflammatory drugs such as aspirin are used for the treatment of cardiovascular disease. Chronic use of low-dose aspirin is associated with the occurrence of gastric ulcer. The aim of this study was to investigate the healing potential of Lycium barbarum polysaccharides (LBP) from ChineseGoji berry and C-phycocyanin (CPC) from Spirulina platensis on gastric ulcer in rats. METHODS: Male Sprague-Dawley rats were divided into five groups: normal, aspirin (700 mg/kg bw), LBP (aspirin + 100 mg/kg bw/d LBP), CPC (aspirin + 50 mg/kg bw/d CPC), and MIX (aspirin + 50 mg/kg bw/d LBP + 25 mg/kg bw/d CPC) groups. Gastric ulcer was developed by daily oral feeding of aspirin for 8 weeks. Treatments were given orally a week before ulcer induction for 9 weeks. RESULTS: The MIX group elevated gastric cyclooxygenase-1, prostaglandin E2, and total nitrite and nitrate levels by 139%, 86%, and 66%, respectively, compared with the aspirin group (p < 0.05). Moreover, the MIX group reduced lipid peroxidesmalondialdehyde levels by 78% (p < 0.05). The treatment of LBP and/or CPC increased gastric Bifidobacterium relative abundance by 2.5-4.0 times compared with the aspirin group (p < 0.05). CONCLUSIONS: We conclude that combined LBP and CPC enhance gastroprotective factors, inhibit lipid peroxidation, and increase gastric Bifidobacterium relative abundance. Combined LBP and CPC have protective potential against gastric ulcer caused by aspirin in rats.
Authors: Hui Xia; Beijia Zhou; Jing Sui; Wenqing Ma; Shaokang Wang; Ligang Yang; Guiju Sun Journal: Int J Environ Res Public Health Date: 2022-09-24 Impact factor: 4.614