PURPOSE: Incidence rate (IR) estimates for peptic ulcer disease (PUD) vary widely among studies. We conducted a systematic review to quantify and examine the discrepancies. METHODS: Of 4780 articles identified from PubMed and EMBASE databases, 31 published in the last three decades that had reported IRs of PUD in the general population were included. Random effects meta-analysis and meta-regression were performed to calculate pooled estimates and to identify sources of heterogeneity. RESULTS: The pooled IR estimate per 1000 person-years was 0.90 (95% confidence interval: 0.78-1.04) for uncomplicated PUD, 0.57 (0.49-0.65) for peptic ulcer bleeding, 0.10 (0.08-0.13) for gastrointestinal perforations, and 3.18 (2.05-4.92) for nonspecific PUD. Within specific outcomes definitions, IR estimates were significantly lower in studies with restriction to hospitalized cases, case validation, and case ascertainment directly from hospital or clinical sources versus computerized health care databases. Younger age, female sex, and later calendar time were also associated with lower PUD incidence. CONCLUSIONS: We found that the IR of uncomplicated PUD was in the order of one case per 1000 person-years in the general population, and that the IR of peptic ulcer complications was around 0.7 cases per 1000 person-years. Comparisons of IR estimates among studies need to take into account disease definition and other study characteristics, particularly whether outcome validation was performed in computerized claims. The use of claims to identify PUD cases might overestimate the IR by around 45%.
PURPOSE: Incidence rate (IR) estimates for peptic ulcer disease (PUD) vary widely among studies. We conducted a systematic review to quantify and examine the discrepancies. METHODS: Of 4780 articles identified from PubMed and EMBASE databases, 31 published in the last three decades that had reported IRs of PUD in the general population were included. Random effects meta-analysis and meta-regression were performed to calculate pooled estimates and to identify sources of heterogeneity. RESULTS: The pooled IR estimate per 1000 person-years was 0.90 (95% confidence interval: 0.78-1.04) for uncomplicated PUD, 0.57 (0.49-0.65) for peptic ulcer bleeding, 0.10 (0.08-0.13) for gastrointestinal perforations, and 3.18 (2.05-4.92) for nonspecific PUD. Within specific outcomes definitions, IR estimates were significantly lower in studies with restriction to hospitalized cases, case validation, and case ascertainment directly from hospital or clinical sources versus computerized health care databases. Younger age, female sex, and later calendar time were also associated with lower PUD incidence. CONCLUSIONS: We found that the IR of uncomplicated PUD was in the order of one case per 1000 person-years in the general population, and that the IR of peptic ulcer complications was around 0.7 cases per 1000 person-years. Comparisons of IR estimates among studies need to take into account disease definition and other study characteristics, particularly whether outcome validation was performed in computerized claims. The use of claims to identify PUD cases might overestimate the IR by around 45%.
Authors: Ravindra Uppaluri; Ashley E Winkler; Tianxiang Lin; Jonathan H Law; Bruce H Haughey; Brian Nussenbaum; Randal C Paniello; Jason T Rich; Jason A Diaz; Loren P Michel; Tanya Wildes; Gavin P Dunn; Paul Zolkind; Dorina Kallogjeri; Jay F Piccirillo; Farrokh Dehdashti; Barry A Siegel; Rebecca D Chernock; James S Lewis; Douglas R Adkins Journal: Clin Cancer Res Date: 2016-11-09 Impact factor: 12.531
Authors: Shahram Golbabapour; Maryam Hajrezaie; Pouya Hassandarvish; Nazia Abdul Majid; A Hamid A Hadi; Noraziah Nordin; Mahmood A Abdulla Journal: Biomed Res Int Date: 2013-05-28 Impact factor: 3.411
Authors: Ana Ruigómez; Saga Johansson; Péter Nagy; Mar Martín-Pérez; Luis A García Rodríguez Journal: BMC Gastroenterol Date: 2014-12-10 Impact factor: 3.067