Literature DB >> 33405212

SPION and doxorubicin-loaded polymeric nanocarriers for glioblastoma theranostics.

Edurne Luque-Michel1,2, Laurent Lemaire3,4, Maria J Blanco-Prieto5,6.   

Abstract

Glioma is a type of cancer with a very poor prognosis with a survival of around 15 months in the case of glioblastoma multiforme (GBM). In order to advance in personalized medicine, we developed polymeric nanoparticles (PNP) loaded with both SPION (superparamagnetic iron oxide nanoparticles) and doxorubicin (DOX). The former being used for its potential to accumulate the PNP in the tumor under a strong magnetic field and the later for its therapeutic potential. The emulsion solvent and evaporation method was selected to develop monodisperse PNP with high loading efficiency in both SPION and DOX. Once injected in mice, a significant accumulation of the PNP was observed within the tumoral tissue under static magnetic field as observed by MRI leading to a reduction of tumor growth rate.

Entities:  

Keywords:  Glioma; MRI; PLGA; SPION; Tumor doubling time; Tween 80; U87-MG

Mesh：

Substances：

Year:  2021        PMID： 33405212     DOI： 10.1007/s13346-020-00880-8

Source DB:  PubMed          Journal:  Drug Deliv Transl Res        ISSN： 2190-393X            Impact factor:   4.617


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