Literature DB >> 33401580

Lactoferrin: A Glycoprotein Involved in Immunomodulation, Anticancer, and Antimicrobial Processes.

Quintín Rascón-Cruz1, Edward A Espinoza-Sánchez1, Tania S Siqueiros-Cendón1, Sayuri I Nakamura-Bencomo1, Sigifredo Arévalo-Gallegos1, Blanca F Iglesias-Figueroa1.   

Abstract

Lactoferrin is an iron binding glycoprotein with multiple roles in the body. Its participation in apoptotic processes in cancer cells, its ability to modulate various reactions of the immune system, and its activity against a broad spectrum of pathogenic microorganisms, including respiratory viruses, have made it a protein of broad interest in pharmaceutical and food research and industry. In this review, we have focused on describing the most important functions of lactoferrin and the possible mechanisms of action that lead to its function.

Entities:  

Keywords:  anti-cancer activity; antibacterial activity; immune system; lactoferrin

Year:  2021        PMID: 33401580      PMCID: PMC7795860          DOI: 10.3390/molecules26010205

Source DB:  PubMed          Journal:  Molecules        ISSN: 1420-3049            Impact factor:   4.411


  132 in total

1.  Lactoferrin is synthesized by activated microglia in the human substantia nigra and its synthesis by the human microglial CHME cell line is upregulated by tumor necrosis factor alpha or 1-methyl-4-phenylpyridinium treatment.

Authors:  C Fillebeen; M M Ruchoux; V Mitchell; S Vincent; M Benaïssa; A Pierce
Journal:  Brain Res Mol Brain Res       Date:  2001-11-30

2.  Antiparasitic and immunomodulatory potential of oral nanocapsules encapsulated lactoferrin protein against Plasmodium berghei.

Authors:  Namrata Anand; Rupinder K Kanwar; Rakesh Sehgal; Jagat R Kanwar
Journal:  Nanomedicine (Lond)       Date:  2015-12-11       Impact factor: 5.307

Review 3.  Physiology of microglia.

Authors:  Helmut Kettenmann; Uwe-Karsten Hanisch; Mami Noda; Alexei Verkhratsky
Journal:  Physiol Rev       Date:  2011-04       Impact factor: 37.312

Review 4.  Potential lactoferrin activity against pathogenic viruses.

Authors:  Elrashdy M Redwan; Vladimir N Uversky; Esmail M El-Fakharany; Hussein Al-Mehdar
Journal:  C R Biol       Date:  2014-09-22       Impact factor: 1.583

Review 5.  Lactoferrin, a Pleiotropic Protein in Health and Disease.

Authors:  Sylvain Mayeur; Schohraya Spahis; Yves Pouliot; Emile Levy
Journal:  Antioxid Redox Signal       Date:  2016-03-16       Impact factor: 8.401

Review 6.  Impaired glucose tolerance and metabolic syndrome in idiopathic neuropathy.

Authors:  A Gordon Smith
Journal:  J Peripher Nerv Syst       Date:  2012-05       Impact factor: 3.494

Review 7.  Heme oxygenase-1 as a therapeutic target in neurodegenerative diseases and brain infections.

Authors:  Antonio Cuadrado; Ana I Rojo
Journal:  Curr Pharm Des       Date:  2008       Impact factor: 3.116

8.  Prevalence of lower-extremity disease in the US adult population >=40 years of age with and without diabetes: 1999-2000 national health and nutrition examination survey.

Authors:  Edward W Gregg; Paul Sorlie; Ryne Paulose-Ram; Qiuping Gu; Mark S Eberhardt; Michael Wolz; Vicki Burt; Lester Curtin; Michael Engelgau; Linda Geiss
Journal:  Diabetes Care       Date:  2004-07       Impact factor: 19.112

Review 9.  Studying Lactoferrin N-Glycosylation.

Authors:  Sercan Karav; J Bruce German; Camille Rouquié; Annabelle Le Parc; Daniela Barile
Journal:  Int J Mol Sci       Date:  2017-04-20       Impact factor: 5.923

Review 10.  Lactoferrin a multiple bioactive protein: an overview.

Authors:  Isui Abril García-Montoya; Tania Siqueiros Cendón; Sigifredo Arévalo-Gallegos; Quintín Rascón-Cruz
Journal:  Biochim Biophys Acta       Date:  2011-06-25
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  9 in total

1.  Recombinant Human Lactoferrin Reduces Inflammation and Increases Fluoroquinolone Penetration to Primary Granulomas During Mycobacterial Infection of C57Bl/6 Mice.

Authors:  Thao K T Nguyen; Zainab Niaz; Marian L Kruzel; Jeffrey K Actor
Journal:  Arch Immunol Ther Exp (Warsz)       Date:  2022-02-28       Impact factor: 4.291

Review 2.  Parkinson's Disease and SARS-CoV-2 Infection: Particularities of Molecular and Cellular Mechanisms Regarding Pathogenesis and Treatment.

Authors:  Aurelian Anghelescu; Gelu Onose; Cristina Popescu; Mihai Băilă; Simona Isabelle Stoica; Ruxandra Postoiu; Elena Brumă; Irina Raluca Petcu; Vlad Ciobanu; Constantin Munteanu
Journal:  Biomedicines       Date:  2022-04-26

Review 3.  Lactoferrin as a Human Genome "Guardian"-An Overall Point of View.

Authors:  Iwona Bukowska-Ośko; Dorota Sulejczak; Katarzyna Kaczyńska; Patrycja Kleczkowska; Karol Kramkowski; Marta Popiel; Ewa Wietrak; Paweł Kowalczyk
Journal:  Int J Mol Sci       Date:  2022-05-08       Impact factor: 6.208

Review 4.  The Lactoferrin Phenomenon-A Miracle Molecule.

Authors:  Paweł Kowalczyk; Katarzyna Kaczyńska; Patrycja Kleczkowska; Iwona Bukowska-Ośko; Karol Kramkowski; Dorota Sulejczak
Journal:  Molecules       Date:  2022-05-04       Impact factor: 4.927

5.  Lactoferrin Inhibition of the Complex Formation between ACE2 Receptor and SARS CoV-2 Recognition Binding Domain.

Authors:  Roberta Piacentini; Laura Centi; Mattia Miotto; Edoardo Milanetti; Lorenzo Di Rienzo; Martina Pitea; Paolo Piazza; Giancarlo Ruocco; Alberto Boffi; Giacomo Parisi
Journal:  Int J Mol Sci       Date:  2022-05-13       Impact factor: 6.208

6.  A Novel Human Recombinant Lactoferrin Inhibits Lung Adenocarcinoma Cell Growth and Migration with No Cytotoxic Effect on Normal Human Epithelial Cells.

Authors:  Paulina Olszewska; Barbara Pazdrak; Marian L Kruzel
Journal:  Arch Immunol Ther Exp (Warsz)       Date:  2021-11-08       Impact factor: 4.291

7.  Role of sialylated glycans on bovine lactoferrin against influenza virus.

Authors:  Xilong Wang; Lixin Yue; Liuyi Dang; Jiajun Yang; Zhuo Chen; Xiurong Wang; Jian Shu; Zheng Li
Journal:  Glycoconj J       Date:  2021-11-15       Impact factor: 3.009

8.  Suppressive Role of Lactoferrin in Overweight-Related Female Fertility Problems.

Authors:  Ban Sato; Seiya Kanai; Daiki Sakaguchi; Kodai Yajima; Yu Matsumoto; Kazunori Morohoshi; Shinji Kagaya; Nobuo Izumo; Minoru Ichinose; Woojin Kang; Mami Miyado; Kenji Miyado; Natsuko Kawano
Journal:  Nutrients       Date:  2022-02-22       Impact factor: 5.717

Review 9.  Natural Peptides Inducing Cancer Cell Death: Mechanisms and Properties of Specific Candidates for Cancer Therapeutics.

Authors:  Plinio A Trinidad-Calderón; Carlos Daniel Varela-Chinchilla; Silverio García-Lara
Journal:  Molecules       Date:  2021-12-09       Impact factor: 4.411

  9 in total

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